Proteostasis Deficiencies

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  Subject Areas on Research

  • Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration. 
  • Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases. 
  • Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. 
  • Parkinson's disease from the gut. 
  • X-Linked Spinal and Bulbar Muscular Atrophy: From Clinical Genetic Features and Molecular Pathology to Mechanisms Underlying Disease Toxicity. 
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  Keywords of People

  • Cortes, Constanza J, Adjunct Assistant Professor in the Department of Neurology, Center for the Study of Aging and Human Development