High-Throughput Screening Assays
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Subject Areas on Research
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A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.
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A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.
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A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer.
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A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening.
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A densely interconnected genome-wide network of microRNAs and oncogenic pathways revealed using gene expression signatures.
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A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.
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A high-throughput histoarray for quantitative molecular profiling of multiple, uniformly oriented medaka (Oryzias latipes) embryos.
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A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent.
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A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.
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A rapid and affordable screening platform for membrane protein trafficking.
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A review of three-dimensional in vitro tissue models for drug discovery and transport studies.
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A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.
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Acoustic separation of circulating tumor cells.
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Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies.
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Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
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An extractive removal step optimized for a high-throughput α-cellulose extraction method for δ13C and δ18O stable isotope ratio analysis in conifer tree rings.
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Assessing locomotor activity in larval zebrafish: Influence of extrinsic and intrinsic variables.
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Assessment of genetic and nongenetic interactions for the prediction of depressive symptomatology: an analysis of the Wisconsin Longitudinal Study using machine learning algorithms.
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Bayesian Multi-Plate High-Throughput Screening of Compounds.
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Bisphenol A affects androgen receptor function via multiple mechanisms.
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Characterization of Plasmodium liver stage inhibition by halofuginone.
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Characterizing sources of variability in zebrafish embryo screening protocols.
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Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation.
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Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine.
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Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease.
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CometChip enables parallel analysis of multiple DNA repair activities.
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Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter.
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Computationally guided high-throughput design of self-assembling drug nanoparticles.
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DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia.
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Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system.
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Designing a Better Mousetrap: Reflections on the November 28, 2017, US Food and Drug Administration Meeting on Next-Generation "High-Sensitivity" Cardiac Troponin Assays to Diagnose Myocardial Infarction.
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Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes.
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Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays.
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Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLpro Reporter Assay.
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Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors.
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Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.
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Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer.
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Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.
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Digital microfluidics comes of age: high-throughput screening to bedside diagnostic testing for genetic disorders in newborns.
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Emerging Technologies for Gut Microbiome Research.
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Expanding the test set: Chemicals with potential to disrupt mammalian brain development.
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First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.
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Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.
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Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA.
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Genetic Analysis of Complex Traits in Saccharomyces cerevisiae
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Genetic Dissection of Heritable Traits in Yeast Using Bulk Segregant Analysis.
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HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair.
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High spatial resolution proteomic comparison of the brain in humans and chimpanzees.
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High-Throughput Computational Search for Half-Metallic Oxides.
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High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity.
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High-Throughput Tissue Bioenergetics Analysis Reveals Identical Metabolic Allometric Scaling for Teleost Hearts and Whole Organisms.
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High-Throughput Video Processing of Heart Rate Responses in Multiple Wild-type Embryonic Zebrafish per Imaging Field.
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High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.
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High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays.
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High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor.
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High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
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High-throughput phenotyping of multicellular organisms: finding the link between genotype and phenotype.
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High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.
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High-throughput screening for modulators of cellular contractile force.
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High-throughput targeted proteomics discovery approach and spontaneous reperfusion in ST-segment elevation myocardial infarction.
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Human genome-wide measurement of drug-responsive regulatory activity.
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IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.
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Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.
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In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.
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Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.
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Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology.
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Isolation and optimization of murine IL-10 receptor blocking oligonucleotide aptamers using high-throughput sequencing.
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LabKey Server NAb: a tool for analyzing, visualizing and sharing results from neutralizing antibody assays.
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay.
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Loss-of-Function RNAi Screen to Identify Necrosis-Signaling Molecules.
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Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue.
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Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes.
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Multiplex newborn screening for Pompe, Fabry, Hunter, Gaucher, and Hurler diseases using a digital microfluidic platform.
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Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens.
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Nuclear morphology measurements with angle-resolved low coherence interferometry for application to cell biology and early cancer detection.
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On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals.
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Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells.
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Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.
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Performance of a new, rapid, automated immunoassay for the detection of anti-platelet factor 4/heparin complex antibodies.
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Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways.
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Predicting protein-ligand interactions based on bow-pharmacological space and Bayesian additive regression trees.
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Protein-DNA binding in the absence of specific base-pair recognition.
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Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer.
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Robust, linear correlations between growth rates and β-lactam-mediated lysis rates.
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Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.
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Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing.
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Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.
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Serologic screening of United States blood donors for Babesia microti using an investigational enzyme immunoassay.
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Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.
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Targeting RNA with small molecules: from fundamental principles towards the clinic.
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Taxonomic applicability of inflammatory cytokines in adverse outcome pathway (AOP) development.
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The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.
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The Phenix software for automated determination of macromolecular structures.
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The zebrafish embryo model in toxicology and teratology, September 2–3, 2010, Karlsruhe, Germany.
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Tissue-engineered blood vessels as promising tools for testing drug toxicity.
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Transcriptional regulation improves the throughput of three-hybrid counter selections in Saccharomyces cerevisiae.
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Keywords of People
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Calakos, Nicole,
Lincoln Financial Group Distinguished Professor of Neurobiology,
Duke Science & Society
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Ferrari, Guido,
Professor in Surgery,
Molecular Genetics and Microbiology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Immunology