Translational Medical Research

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  Subject Areas on Research

  • 2012 American Pancreatic Association presidential address: Fostering translation. 
  • 2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardiovascular Endpoints Data Standards). 
  • 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. 
  • A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research. 
  • A Plan for Academic Biobank Solvency-Leveraging Resources and Applying Business Processes to Improve Sustainability. 
  • A hub for bench-to-bedside pharmacogenomic-based research. 
  • A message from the Editor-in-Chief. 
  • A national strategy to develop pragmatic clinical trials infrastructure. 
  • A new model for catalyzing translational science: the early stage investigator mentored research scholar program in HIV vaccines. 
  • A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. 
  • A roadmap for academic health centers to establish good laboratory practice-compliant infrastructure. 
  • A translatable predictor of human radiation exposure. 
  • A translational bridge between mouse and human models of learned safety. 
  • A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. 
  • Activity-related energy expenditure in older adults: a call for more research. 
  • Adherence to antiemetic guidelines in patients with malignant glioma: a quality improvement project to translate evidence into practice. 
  • Advances in basic and translational tuberculosis research: Proceedings of the first meeting of RePORT international. 
  • Aligning the goals of community-engaged research: why and how academic health centers can successfully engage with communities to improve health. 
  • American industry and the U.S. Cardiovascular Clinical Research Enterprise an appropriate analogy? 
  • An Eclectic Review of the History of Peripheral Nerve Surgery. 
  • An Introduction to Pathology in Biomedical Research: A Mission-Critical Specialty for Reproducibility and Rigor in Translational Research. 
  • An outcome model approach to transporting a randomized controlled trial results to a target population. 
  • Anesthetic neuroprotection: antecedents and an appraisal of preclinical and clinical data quality. 
  • Antithrombotic Therapy in Peripheral Artery Disease: Generating and Translating Evidence Into Practice. 
  • Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model. 
  • Basic and Translational Research in Intracerebral Hemorrhage: Limitations, Priorities, and Recommendations. 
  • Battlefield to Bedside: Bringing Precision Medicine to Surgical Care. 
  • Big data, data science, and big contributions. 
  • Bioelectronic medicines: a research roadmap. 
  • Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation. 
  • Biomarkers for smoking cessation. 
  • Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. Louis workshop. 
  • Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates. 
  • Building a platform for translational research in chronic noncommunicable diseases to address population health: lessons from NHLBI supported CRONICAS in Peru. 
  • Building a primary care/research partnership: lessons learned from a telehealth intervention for diabetes and depression. 
  • CTSA Consortium Consensus Scientific Review Committee (SRC) Working Group Report on the SRC Processes. 
  • Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. 
  • Cardiovascular research in India: a perspective. 
  • Challenges facing translational research organizations in China: a qualitative multiple case study. 
  • Changing trends of blindness: the initial harvest from translational public health and clinical research in ophthalmology. 
  • Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology. 
  • Clinical and translational scientist career success: metrics for evaluation. 
  • Clinical development of pharmacologic agents for acute heart failure syndromes: a proposal for a mechanistic translational phase. 
  • Clinical research sites--the underappreciated component of the clinical research system. 
  • Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey. 
  • Colorectal cancer models for novel drug discovery. 
  • Combat Wound Initiative program. 
  • Comparative effectiveness research in cancer genomics and precision medicine: current landscape and future prospects. 
  • Context matters in child and family policy. 
  • Crafting a national agenda for nursing education research. 
  • Creating the Next Generation of Translational Geroscientists. 
  • Current Treatment, Emerging Translational Therapies, and New Therapeutic Targets for Autoimmune Myasthenia Gravis. 
  • Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary. 
  • Cytotoxic T-lymphocyte-associated antigen-4. 
  • Defining translational research: implications for training. 
  • Department of Veterans Affairs Geriatric Research, Education and Clinical Centers: translating aging research into clinical geriatrics. 
  • Design and Implementation of the International Genetics and Translational Research in Transplantation Network. 
  • Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. 
  • Direct2Experts: a pilot national network to demonstrate interoperability among research-networking platforms. 
  • Establishing a framework for improving the quality of clinical and translational research. 
  • Failure to reassess ejection fraction after acute myocardial infarction in potential implantable cardioverter/defibrillator candidates: insights from the Translational Research Investigating Underlying disparities in acute Myocardial infarction Patients' Health Status (TRIUMPH) registry. 
  • Fear and anxiety from principle to practice: implications for when to treat youth with anxiety disorders. 
  • Finding translation in stress research. 
  • Focus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and recipient of the 2007 National Medal of Science by Elaine Musgrave. 
  • Fostering innovation in medicine and health care: what must academic health centers do? 
  • Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. 
  • Genetic polymorphisms: a cornerstone of translational biobehavioral research. 
  • Genetic variation in IL28B: impact on drug development for chronic hepatitis C infection. 
  • Genetics in population health science: strategies and opportunities. 
  • Genome-wide association studies in asthma: what they really told us about pathogenesis. 
  • Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology. 
  • Genomics, clinical research, and learning health care systems: Strategies to improve patient care. 
  • Genomics-enabled drug repositioning and repurposing: insights from an IOM Roundtable activity. 
  • Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. 
  • Harnessing the microbiota to treat neurological diseases
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  • Healing With CAARE: An Oasis of Care in the Changing Landscape of Translational Science. 
  • How to bridge the "valley of death" between a research discovery and clinical application? 
  • Identifying and aligning expectations in a mentoring relationship. 
  • ImPlementation REsearCh to DEvelop Interventions for People Living with HIV (the PRECluDE consortium): Combatting chronic disease comorbidities in HIV populations through implementation research. 
  • Immunotherapy for primary brain tumors: no longer a matter of privilege. 
  • Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in oncology. 
  • Improving the assessment of heart toxicity for all new drugs through translational regulatory science. 
  • Improving the management of dyspnea in the community using rapid learning approaches. 
  • Incorporating research into thoracic surgery practice. 
  • Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview. 
  • Intra-Target Microdosing (ITM): A Novel Drug Development Approach Aimed at Enabling Safer and Earlier Translation of Biological Insights Into Human Testing. 
  • Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia. 
  • Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. 
  • Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards. 
  • Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks? 
  • MRI assessment of bone structure and microarchitecture. 
  • Making Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable. 
  • Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2. 
  • Medical genomics: Gather and use genetic data in health care. 
  • Mentoring in Clinical-Translational Research: A Study of Participants in Master's Degree Programs. 
  • Mesenchymal stem cells in obesity: insights for translational applications. 
  • Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. 
  • Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. 
  • Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. 
  • Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective. 
  • Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. 
  • Myelodysplastic syndromes in the United States: an update for clinicians. 
  • New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia. 
  • Noninvasive brain-computer interface enables communication after brainstem stroke. 
  • Novel immunotherapeutic strategies in development for renal cell carcinoma. 
  • Oncology service initiatives and research in regional Australia. 
  • Opening up to precompetitive collaboration. 
  • Optimizing the translational value of animal models of glomerulonephritis: insights from recent murine prototypes. 
  • Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development. 
  • Pathology Study Design, Conduct, and Reporting to Achieve Rigor and Reproducibility in Translational Research Using Animal Models. 
  • Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach. 
  • Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. 
  • Physical function and independence 1 year after myocardial infarction: observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. 
  • Platelet-Mediated Thrombosis: From Bench to Bedside. 
  • Practical murine hematopathology: a comparative review and implications for research. 
  • Practice-based Research Network Research Good Practices (PRGPs): Summary of Recommendations. 
  • Practices and perspectives on building integrated data repositories: results from a 2010 CTSA survey. 
  • Precision Medicine: From Science To Value. 
  • Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5. 
  • Priorities for Cardiovascular Outcomes Research: A Report of the National Heart, Lung, and Blood Institute's Centers for Cardiovascular Outcomes Research Working Group. 
  • Putting evidence for diabetes care into practice. 
  • Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. 
  • Reengineered AAV vectors: old dog, new tricks. 
  • Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium. 
  • Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Urinary Incontinence in Older Adults: A Translational Research Agenda for a Complex Geriatric Syndrome. 
  • Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation. 
  • Research management team (RMT): a model for research support services at Duke University. 
  • Research on HIV cure: Mapping the ethics landscape. 
  • Research without borders: fostering innovative clinical research and implementation. 
  • Reverse Translation in Advancing Pharmacotherapy in Pediatric Rheumatology: A Logical Approach in Rare Diseases with Limited Resources. 
  • Risk factors for autism: translating genomic discoveries into diagnostics. 
  • Self-Regulation and Psychopathology: Toward an Integrative Translational Research Paradigm. 
  • Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry. 
  • Spinal cord injury pharmacotherapy: Current research & development and competitive commercial landscape as of 2015. 
  • Spotlight on zebrafish: the next wave of translational research. 
  • Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach. 
  • Statistical aspect of translational and correlative studies in clinical trials. 
  • Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report. 
  • Support for investigator-initiated clinical research involving investigational drugs or devices: the Clinical and Translational Science Award experience. 
  • Systems science and childhood obesity: a systematic review and new directions. 
  • TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. 
  • Team Science Approach to Developing Consensus on Research Good Practices for Practice-Based Research Networks: A Case Study. 
  • Text data extraction for a prospective, research-focused data mart: implementation and validation. 
  • The 2009 Feinberg lecture: the continuum of stroke research and policy. 
  • The AGING Initiative experience: a call for sustained support for team science networks. 
  • The Biomedical Resource Ontology (BRO) to enable resource discovery in clinical and translational research. 
  • The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans: Toward Comparative Effectiveness in the Pediatric Rheumatic Diseases. 
  • The Research RVU (rRVU): In Search of a Methodology to Incentivize and Compensate Clinicians for Participation in Clinical Research Activities. 
  • The Role of the IACUC in the Design and Conduct of Animal Experiments that Contribute to Translational Success. 
  • The Singapore flagship programme in translational and clinical research in psychosis. 
  • The coming age of data-driven medicine: translational bioinformatics' next frontier. 
  • The continuum of translational research: special issue from the Council for the Advancement of Nursing Science. 
  • The last mile: translational research to improve CKD outcomes. 
  • The need for academic leadership in full-spectrum translational research. 
  • The path forward: collaborative networks and the future for children's health care. 
  • The role of academic health science systems in the transformation of medicine. 
  • The sickle cell disease implementation consortium: Translating evidence-based guidelines into practice for sickle cell disease. 
  • Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles. 
  • Transforming Evidence Generation to Support Health and Health Care Decisions. 
  • Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial. 
  • Translating genetic findings in hereditary nephrotic syndrome: the missing loops. 
  • Translating neuroscience to the front lines: point-of-care detection of neuropsychiatric disorders. 
  • Translating nucleic acid aptamers to antithrombotic drugs in cardiovascular medicine. 
  • Translating promising strategies for bowel and bladder management in spinal cord injury. 
  • Translating protein phosphatase research into treatments for neurodegenerative diseases. 
  • Translating the Translation: What Clinicians Should Know About the Fourth Universal Definition of Myocardial Infarction. 
  • Translating tuberculosis research into practice: collaboration between academic researchers and public health departments in North Carolina. 
  • Translation of acute coronary syndrome therapies: from evidence to routine clinical practice. 
  • Translation, treatises, and tweets. 
  • Translational bioinformatics in mental health: open access data sources and computational biomarker discovery. 
  • Translational impact of NIH-funded nonhuman primate research in transplantation. 
  • Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps? 
  • Translational research in acute central nervous system injury: lessons learned and the future. 
  • Translational toxicology: a developmental focus for integrated research strategies. 
  • Tumor Heterogeneity and Therapeutic Resistance. 
  • Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. 
  • Updates in advanced prostate cancer 2018. 
  • Use Patents Can Be Useful: The Case of Rescued Drugs 
  • What do international pharmacoeconomic guidelines say about economic data transferability? 
  • What is the role of culture, diversity, and community engagement in transdisciplinary translational science? 
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  Keywords of People

  • Dodge, Kenneth A., William McDougall Distinguished Professor of Public Policy Studies, Duke Science & Society
  • El-Gharbawy, Areeg Hassan, Associate Professor of Pediatrics, Pediatrics, Medical Genetics
  • Fecci, Peter Edward, Associate Professor of Neurosurgery, Immunology
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia
  • MacLeod, Amanda S, Adjunct Associate Professor in the Department of Dermatology, Immunology
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Patil, Sunita, Assoc Dir, Research Operations, Duke Clinical & Translational Science Institute
  • Pencina, Michael J, Professor of Biostatistics & Bioinformatics, School of Medicine
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology