Frontotemporal Dementia

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  Subject Areas on Research

  • ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy. 
  • Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia. 
  • Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations. 
  • Brain PET in the diagnosis of Alzheimer's disease. 
  • Complete Evaluation of Dementia: PET and MRI Correlation and Diagnosis for the Neuroradiologist. 
  • Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. 
  • Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. 
  • Identification of a pathogenic intronic KIF5A mutation in an ALS-FTD kindred. 
  • Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making. 
  • LATE-NC staging in routine neuropathologic diagnosis: an update. 
  • PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction. 
  • Progressive supranuclear palsy and primary lateral sclerosis secondary to globular glial tauopathy: a case report and a practical theoretical framework for the clinical prediction of this rare pathological entity. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice. 
  • Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia. 
  • The New Science of Practical Wisdom. 
  • Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference. 
  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. 
  • Validation of consensus panel diagnosis in dementia. 
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  Keywords of People

  • Genao Gonzalez, Liza Isabel, Assistant Professor of Medicine, Medicine, Geriatrics