Mendelian Randomization Analysis

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  Subject Areas on Research

  • A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. 
  • Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19. 
  • Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study. 
  • Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. 
  • Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. 
  • Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. 
  • Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. 
  • Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies. 
  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. 
  • Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses. 
  • Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. 
  • Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study. 
  • Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study. 
  • Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses. 
  • Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. 
  • Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study. 
  • Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease. 
  • Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study. 
  • Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study. 
  • Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study. 
  • Common variants in Mendelian kidney disease genes and their association with renal function. 
  • Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. 
  • DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. 
  • Dominance rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons. 
  • Evaluating the role of alcohol consumption in breast and ovarian cancer susceptibility using population-based cohort studies and two-sample Mendelian randomization analyses. 
  • Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. 
  • Feasibility of a Risk-Based Approach to Cataract Surgery Preoperative Medical Evaluation. 
  • GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. 
  • Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men. 
  • Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. 
  • Genetic associations with valvular calcification and aortic stenosis. 
  • Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma. 
  • Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. 
  • Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study. 
  • Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. 
  • Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. 
  • HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization. 
  • Impact of atopy on risk of glioma: a Mendelian randomisation study. 
  • Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis. 
  • Mendelian randomisation study of the relationship between vitamin D and risk of glioma. 
  • Mendelian randomization provides support for obesity as a risk factor for meningioma. 
  • Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer. 
  • Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. 
  • Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects. 
  • Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis. 
  • Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study. 
  • Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis. 
  • Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study. 
  • The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study. 
  • Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization. 
  • Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. 
  • Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study. 
  • Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults.