Comparative Effectiveness Research

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  Subject Areas on Research

  • A Multilevel Approach to Stakeholder Engagement in the Formulation of a Clinical Data Research Network. 
  • A model for incorporating patient and stakeholder voices in a learning health care network: Washington State's Comparative Effectiveness Research Translation Network. 
  • An evaluation of recent federal spending on comparative effectiveness research: priorities, gaps, and next steps. 
  • An evaluation of stakeholder engagement in comparative effectiveness research: lessons learned from SWOG S1415CD. 
  • Approaches to comparative effectiveness research in multimorbid populations. 
  • Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program. 
  • Bayesian data analysis in observational comparative effectiveness research: rationale and examples. 
  • Building the evidence base for decision making in cancer genomic medicine using comparative effectiveness research. 
  • Cancer therapy costs influence treatment: a national survey of oncologists. 
  • Cardiovascular imaging research at the crossroads. 
  • Clinical heterogeneity in systematic reviews and health technology assessments: synthesis of guidance documents and the literature. 
  • Clinical outcomes with rivaroxaban in patients transitioned from vitamin K antagonist therapy: a subgroup analysis of a randomized trial. 
  • Comparative Effectiveness Research: Alternatives to "Traditional" Computed Tomography Use in the Acute Care Setting. 
  • Comparative Effectiveness Trials of Imaging-Guided Strategies in Stable Ischemic Heart Disease. 
  • Comparative Effectiveness of CRT-D Versus Defibrillator Alone in HF Patients With Moderate-to-Severe Chronic Kidney Disease. 
  • Comparative Effectiveness of Cardiac Resynchronization Therapy Among Patients With Heart Failure and Atrial Fibrillation: Findings From the National Cardiovascular Data Registry's Implantable Cardioverter-Defibrillator Registry. 
  • Comparative Effectiveness of Hybrid Coronary Revascularization vs Coronary Artery Bypass Grafting. 
  • Comparative Effectiveness of Implantable Cardioverter Defibrillators for Primary Prevention in Women. 
  • Comparative Effectiveness of Medical Therapy, Supervised Exercise, and Revascularization for Patients With Intermittent Claudication: A Network Meta-analysis. 
  • Comparative Effectiveness of Primary Prevention Implantable Cardioverter-Defibrillators in Older Heart Failure Patients With Diabetes Mellitus. 
  • Comparative Effectiveness of β-Blocker Use Beyond 3 Years After Myocardial Infarction and Long-Term Outcomes Among Elderly Patients. 
  • Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations. 
  • Comparative effectiveness clinical trials to advance treatment of myasthenia gravis. 
  • Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. 
  • Comparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study. 
  • Comparative effectiveness of drug-eluting stents on long-term outcomes in elderly patients treated for in-stent restenosis: a report from the National Cardiovascular Data Registry. 
  • Comparative effectiveness of drug-eluting versus bare-metal stents in elderly patients undergoing revascularization of chronic total coronary occlusions: results from the National Cardiovascular Data Registry, 2005-2008. 
  • Comparative effectiveness of dual-action versus single-action antidepressants for the treatment of depression in people living with HIV/AIDS. 
  • Comparative effectiveness of hysterectomy versus myomectomy on one-year health-related quality of life in women with uterine fibroids. 
  • Comparative effectiveness of i-SCAN™ and high-definition white light characterizing small colonic polyps. 
  • Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review. 
  • Comparative effectiveness of nonbiologic versus biologic disease-modifying antirheumatic drugs for rheumatoid arthritis. 
  • Comparative effectiveness of revascularization strategies. 
  • Comparative effectiveness of shock wave lithotripsy and ureteroscopy for treating patients with kidney stones. 
  • Comparative effectiveness of surfactant preparations in premature infants. 
  • Comparative effectiveness of uterine fibroids procedures using linked medical record and claims data. 
  • Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review. 
  • Comparative effectiveness research and demonstrating clinical utility for molecular diagnostic tests. 
  • Comparative effectiveness research in cancer genomics and precision medicine: current landscape and future prospects. 
  • Comparative effectiveness research in kidney disease: a national priority. 
  • Comparative effectiveness research in lung diseases and sleep disorders: recommendations from the National Heart, Lung, and Blood Institute workshop. 
  • Comparative effectiveness research in oncology. 
  • Comparative effectiveness research in oncology: an overview. 
  • Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond. 
  • Comparative effectiveness research: Policy context, methods development and research infrastructure. 
  • Comparative effectiveness research: moving medical oncology forward. 
  • Comparative effectiveness review of antiplatelet agents in peripheral artery disease. 
  • Comparison of Broad vs Narrow Focal Width Lithotripter Fields. 
  • Comparison of Complication Rate Between LeFort III and Monobloc Advancement With or Without Distraction Osteogenesis. 
  • Comparison of Patient Report and Medical Records of Comorbidities: Results From a Population-Based Cohort of Patients With Prostate Cancer. 
  • Comparison of Radial Access, Guided Femoral Access, and Non-Guided Femoral Access Among Women Undergoing Percutaneous Coronary Intervention. 
  • Conscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement: Insights from the National Cardiovascular Data Registry Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. 
  • Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer. 
  • Cost-effectiveness of follow-up of pulmonary nodules incidentally detected on cardiac computed tomographic angiography in patients with suspected coronary artery disease. 
  • Cost-effectiveness of revascularization strategies: the ASCERT study. 
  • Cost-effectiveness of truncated therapy for hepatitis C based on rapid virologic response. 
  • Data sources for heart failure comparative effectiveness research. 
  • Deriving Real-World Insights From Real-World Data: Biostatistics to the Rescue. 
  • Design and rationale of a retrospective clinical effectiveness study of aldosterone antagonist therapy in patients with heart failure. 
  • Design of VA Cooperative Study #591: CERV-PTSD, comparative effectiveness research in veterans with PTSD. 
  • Design of the North Carolina Prostate Cancer Comparative Effectiveness and Survivorship Study (NC ProCESS). 
  • Designing and implementing a comparative effectiveness study of two strategies for delivering high quality CHD prevention: methods and participant characteristics for the Heart to Health study. 
  • Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study. 
  • Diagnostic performance of short portable mental status questionnaire for screening dementia among patients attending cognitive assessment clinics in Singapore. 
  • Does comparative effectiveness research promote rationing of cancer care? 
  • Early Patient-Centered Outcomes Research Experience With the Use of Telehealth to Address Disparities: Scoping Review. 
  • Early use of thrust manipulation versus non-thrust manipulation: a randomized clinical trial. 
  • Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest. 
  • Electronic health records to facilitate clinical research. 
  • Electronic patient-reported data capture as a foundation of rapid learning cancer care. 
  • Epilogue: the peril and the promise of comparative effectiveness research in oncology. 
  • Evaluation of the Use of Cancer Registry Data for Comparative Effectiveness Research. 
  • Evidence from Pragmatic Trials during Routine Care - Slouching toward a Learning Health System. 
  • Evidence-based risk communication: a systematic review. 
  • Field methods in medical record abstraction: assessing the properties of comparative effectiveness estimates. 
  • Financial burden, distress, and toxicity in cardiovascular disease. 
  • Four health data networks illustrate the potential for a shared national multipurpose big-data network. 
  • Future directions for cardiovascular disease comparative effectiveness research: report of a workshop sponsored by the National Heart, Lung, and Blood Institute. 
  • Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes. 
  • ISCHEMIA: Establishing the Primary End Point. 
  • ISOQOL recommends minimum standards for patient-reported outcome measures used in patient-centered outcomes and comparative effectiveness research. 
  • Impact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study. 
  • Impact of immortal person-time and time scale in comparative effectiveness research for medical devices: a case for implantable cardioverter-defibrillators. 
  • Implications of ischaemic area at risk and mode of reperfusion in ST-elevation myocardial infarction. 
  • Improving Comparative Effectiveness Trials. 
  • Improving care of chronic conditions for women veterans: identifying opportunities for comparative effectiveness research. 
  • Indicators of pretreatment suicidal ideation in adults with major depressive disorder. 
  • Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review. 
  • Interventions to improve adherence to self-administered medications for chronic diseases in the United States: a systematic review. 
  • Laparoscopic versus open Hartmann procedure for the emergency treatment of diverticulitis: a propensity-matched analysis. 
  • Leveraging observational registries to inform comparative effectiveness research. 
  • Linked Sensitivity Analysis, Calibration, and Uncertainty Analysis Using a System Dynamics Model for Stroke Comparative Effectiveness Research. 
  • Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research. 
  • Measure once, cut twice--adding patient-reported outcome measures to the electronic health record for comparative effectiveness research. 
  • Methodological considerations in observational comparative effectiveness research for implantable medical devices: an epidemiologic perspective. 
  • Native Tissue Prolapse Repairs: Comparative Effectiveness Trials. 
  • Nonoperative Management Is as Effective as Immediate Splenectomy for Adult Patients with High-Grade Blunt Splenic Injury. 
  • Obesity treatment for socioeconomically disadvantaged patients in primary care practice. 
  • Oncology comparative effectiveness research: a multistakeholder perspective on principles for conduct and reporting. 
  • Outcomes of Shock Wave Lithotripsy and Ureteroscopy for Treatment of Pediatric Urolithiasis. 
  • PROMIS measures of pain, fatigue, negative affect, physical function, and social function demonstrated clinical validity across a range of chronic conditions. 
  • Panel discussion 1. 
  • Patients' Views Concerning Research on Medical Practices: Implications for Consent. 
  • Pediatric post-marketing safety systems in North America: assessment of the current status. 
  • Physicians' perspectives regarding pragmatic clinical trials. 
  • Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial. 
  • Primary prevention implantable cardioverter-defibrillators in older racial and ethnic minority patients. 
  • Priorities for comparative effectiveness reviews in cardiovascular disease. 
  • Prioritization of patient-centered comparative effectiveness research for osteoarthritis. 
  • Prioritization of research addressing antipsychotics for adolescents and young adults with bipolar disorder. 
  • Prognostic Value of Coronary Artery Calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest Pain). 
  • Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition. 
  • Proximal embolic protection versus distal filter protection versus combined protection in carotid artery stenting: A systematic review and meta-analysis. 
  • Quality of life in higher resolution: the next generation of comparative effectiveness research in malignant hematology. 
  • Re-Treatment after Ureteroscopy and Shock Wave Lithotripsy: A Population Based Comparative Effectiveness Study. 
  • Recommendations for incorporating patient-reported outcomes into clinical comparative effectiveness research in adult oncology. 
  • Researchers, Patients, and Stakeholders Evaluating Comparative-Effectiveness Research: A Mixed-Methods Study of the PCORI Reviewer Experience. 
  • Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients: Results From the ROADMAP Study. 
  • Risk assessment and comparative effectiveness of left ventricular assist device and medical management in ambulatory heart failure patients: design and rationale of the ROADMAP clinical trial. 
  • Role of Health Services Research in Producing High-Value Rehabilitation Care. 
  • Setting an agenda for comparative effectiveness systematic reviews in CKD care. 
  • Study design elements for rigorous quasi-experimental comparative effectiveness research. 
  • Substance use disorders and comorbid Axis I and II psychiatric disorders among young psychiatric patients: findings from a large electronic health records database. 
  • Systematic review of disease-modifying antirheumatic drugs for juvenile idiopathic arthritis. 
  • The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans: Toward Comparative Effectiveness in the Pediatric Rheumatic Diseases. 
  • The PCORnet Blood Pressure Control Laboratory: A Platform for Surveillance and Efficient Trials. 
  • The Research RVU (rRVU): In Search of a Methodology to Incentivize and Compensate Clinicians for Participation in Clinical Research Activities. 
  • The economics of heart failure. 
  • The importance of the design of observational studies in comparative effectiveness research: Lessons from the GARFIELD-AF and ORBIT-AF registries. 
  • The use of patient-reported outcomes (PRO) within comparative effectiveness research: implications for clinical practice and health care policy. 
  • Tool for evaluating research implementation challenges: a sense-making protocol for addressing implementation challenges in complex research settings. 
  • Transatlantic Comparison of ST-Segment Elevation Myocardial Infarction Guidelines: Insights From the United States and Europe. 
  • Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial. 
  • Unanticipated Insights into Biomedicine from the Study of Acupuncture. 
  • Understanding the patient experience of pain and discomfort during cardiac catheterization. 
  • Urine NGAL as a biomarker of kidney damage after on- and off-pump coronary artery bypass graft surgery: a prospective pilot study. 
  • Use and Effectiveness of Bivalirudin Versus Unfractionated Heparin for Percutaneous Coronary Intervention Among Patients With ST-Segment Elevation Myocardial Infarction in the United States. 
  • Use of the landmark method to address immortal person-time bias in comparative effectiveness research: a simulation study. 
  • Using a society database to evaluate a patient safety collaborative: the Cardiovascular Surgical Translational Study. 
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  Keywords of People

  • Allen LaPointe, Nancy Marie, Adjunct Associate Professor in the Department of Medicine, Medicine, Cardiology
  • Allori, Alexander C, Associate Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Anderson, Ruth A., Professor Emerita in the School of Nursing, School of Nursing
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Brennan, J. Matthew, Associate Professor of Medicine, Medicine, Cardiology
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Gellad, Ziad F., Associate Professor of Medicine, Medicine, Gastroenterology
  • LeBlanc, Thomas William, Associate Professor of Medicine, Duke Cancer Institute
  • Mac Grory, Brian C., Associate Professor of Neurology, Ophthalmology
  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, School of Nursing
  • Myers, Evan Robert, Walter L. Thomas Distinguished Professor of Obstetrics and Gynecology in the School of Medicine, Duke Cancer Institute
  • Ramirez, Michelle, Student, Population Health Sciences
  • Reed, Shelby Derene, Professor in Population Health Sciences, Duke Science & Society
  • Van Mater, Heather Ann, Associate Professor of Pediatrics, Pediatrics, Rheumatology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine
  • Zafar, Syed Yousuf, Adjunct Professor in the Department of Medicine, Duke Science & Society
  • Zipkin, Daniella Ann, Professor of Medicine, Medicine, General Internal Medicine