Limit of Detection

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  Subject Areas on Research

  • A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate. 
  • A novel cyanide ion sensing approach based on Raman scattering for the detection of environmental cyanides. 
  • A semiparametric modeling approach for analyzing clinical biomarkers restricted to limits of detection. 
  • Allantoin in human urine quantified by ultra-performance liquid chromatography-tandem mass spectrometry. 
  • An antibody-free dual-biomarker rapid enrichment workflow (AnDREW) improves the sensitivity of malaria rapid diagnostic tests. 
  • Analysis of thyroid hormones in serum by liquid chromatography-tandem mass spectrometry. 
  • Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs. 
  • Analytical performance evaluation of the Elecsys® Troponin T Gen 5 STAT assay. 
  • Asbestos Fiber Concentrations in the Lungs of Brake Repair Workers: An Updated Analysis Using Several Regression Methods to Handle Nondetectable Measurements. 
  • Bioplasmonic paper as a platform for detection of kidney cancer biomarkers. 
  • Comparison of Detection Limits of Fourth- and Fifth-Generation Combination HIV Antigen-Antibody, p24 Antigen, and Viral Load Assays on Diverse HIV Isolates. 
  • Consensus guidelines on plasma cell myeloma minimal residual disease analysis and reporting. 
  • Determination of non-Vitamin K oral anticoagulant (NOAC) effects using a new-generation thrombelastography TEG 6s system. 
  • Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumors. 
  • Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine. 
  • Efficient detection of Zika virus RNA in patients' blood from the 2016 outbreak in Campinas, Brazil. 
  • Enantioselective determination of methylphenidate and ritalinic acid in whole blood from forensic cases using automated solid-phase extraction and liquid chromatography-tandem mass spectrometry. 
  • Extending the Sensitivity of CEST NMR Spectroscopy to Micro-to-Millisecond Dynamics in Nucleic Acids Using High-Power Radio-Frequency Fields. 
  • Immunomagnetic capture and colorimetric detection of malarial biomarker Plasmodium falciparum lactate dehydrogenase. 
  • Implanted Nanosensors in Marine Organisms for Physiological Biologging: Design, Feasibility, and Species Variability. 
  • Improving the clinical value of estimating glomerular filtration rate by reporting all values: a contrarian viewpoint. 
  • International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis. 
  • Microvolume trace environmental analysis using peak-focusing online solid-phase extraction-nano-liquid chromatography-high-resolution mass spectrometry. 
  • Nonparametric bayes shrinkage for assessing exposures to mixtures subject to limits of detection. 
  • Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells. 
  • Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1. 
  • Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration. 
  • Performance evaluation of the Helena V8 capillary electrophoresis system. 
  • Pivotal findings for a high-sensitivity cardiac troponin assay: Results of the HIGH-US study. 
  • Poly(amidoamine)-coated magnetic particles for enhanced detection of Schistosoma circulating anodic antigen in endemic urine samples. 
  • Pre-validation of choriogenin H transgenic medaka eleutheroembryos as a quantitative estrogenic activity test method. 
  • Prognostic performance of a high-sensitivity cardiac troponin I assay in patients with non-ST-elevation acute coronary syndrome. 
  • Rapid electrochemical detection on a mobile phone. 
  • Rapid method for the measurement of circulating thyroid hormones in low volumes of teleost fish plasma by LC-ESI/MS/MS. 
  • Reference interval evaluation of high-sensitivity troponin T and N-terminal B-type natriuretic peptide in Vietnam and the US: The North South East West Trial. 
  • Review: A single hs-cTnT with a cutpoint < limit of detection plus a nonischemic ECG can rule out acute MI. 
  • Sensitive DNA detection and SNP discrimination using ultrabright SERS nanorattles and magnetic beads for malaria diagnostics. 
  • Simultaneous quantification of urinary 6‑sulfatoxymelatonin and 8‑hydroxy‑2'‑deoxyguanosine using liquid chromatography-tandem mass spectrometry. 
  • Ultrarapid detection of pathogenic bacteria using a 3D immunomagnetic flow assay. 
  • Using Mass Spectrometry to Quantify Rituximab and Perform Individualized Immunoglobulin Phenotyping in ANCA-Associated Vasculitis. 
  • Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia. 
  • Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS. 
  • miRNA probe integrated biosensor platform using bimetallic nanostars for amplification-free multiplexed detection of circulating colorectal cancer biomarkers in clinical samples.