Mice, 129 Strain
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Subject Areas on Research
- A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.
- A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
- A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels.
- A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.
- Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons.
- Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease.
- Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation.
- An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.
- ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.
- B lymphocytes differentially influence acute and chronic allograft rejection in mice.
- Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.
- Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression.
- CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis.
- Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.
- Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.
- Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease.
- Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
- Developmental onset of enduring long-term potentiation in mouse hippocampus.
- Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.
- Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
- Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
- Dopaminergic abnormalities in Hdac6-deficient mice.
- Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.
- Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury.
- E protein transcription factors are required for the development of CD4(+) lineage T cells.
- Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury.
- Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.
- Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.
- Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function.
- Gene expression profiles linked to AT1 angiotensin receptors in the kidney.
- Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
- Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.
- Glimpse of natural selection of long-lived T-cell clones in healthy life.
- IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
- IL-15 regulates homeostasis and terminal maturation of NKT cells.
- IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity.
- Impairment of kindling development in phospholipase Cγ1 heterozygous mice.
- Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.
- Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.
- KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
- Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
- Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.
- Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord.
- Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.
- NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults.
- Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice.
- Novel intrathecal and subcutaneous catheter delivery systems in the mouse.
- Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice.
- Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.
- Prefrontal cortical mechanisms underlying delayed alternation in mice.
- Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.
- Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization.
- Rare codons capacitate Kras-driven de novo tumorigenesis.
- Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
- Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.
- Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma.
- Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension.
- S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.
- Signaling levels mold the RAS mutation tropism of urethane.
- Sox2 regulates cholinergic amacrine cell positioning and dendritic stratification in the retina.
- Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines.
- Susceptibility to acute mouse adenovirus type 1 respiratory infection and establishment of protective immunity in neonatal mice.
- TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
- Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.
- Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.
- The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.
- The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.
- Type 2 alveolar cells are stem cells in adult lung.
- X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription.
- miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.
- α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.
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Keywords of People
- Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
- Sparks, Matthew A., Associate Professor of Medicine, Medicine, Nephrology
- Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases