Epigenomics

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  Subject Areas on Research

  • 4th International Forum on Rheumatoid Arthritis: Great times near the Great Wall. 
  • A chemical method for labeling lysine methyltransferase substrates. 
  • A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. 
  • A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology. 
  • Acetylation takes aim at mRNA. 
  • Advances in neuroscience. 
  • Advancing drug discovery for schizophrenia. 
  • An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents. 
  • Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology. 
  • Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Bayesian genome- and epigenome-wide association studies with gene level dependence. 
  • Blood Epigenetic Age may Predict Cancer Incidence and Mortality. 
  • Boosting, Not Breaking: CRISPR Activators Treat Disease Models. 
  • Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. 
  • CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome. 
  • CRISPR-based methods for high-throughput annotation of regulatory DNA. 
  • Can laboratory model systems instruct human limb regeneration? 
  • Can we identify meaningful epigenetic effects on human brain function and related risk for mental illness? 
  • Can we observe epigenetic effects on human brain function? 
  • Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal. 
  • Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma. 
  • Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma. 
  • Common non-epigenetic drugs as epigenetic modulators. 
  • Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. 
  • Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. 
  • Comprehensive functional genomic resource and integrative model for the human brain. 
  • Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing. 
  • Defining the replication program through the chromatin landscape. 
  • Diastolic filling vortex forces and cardiac adaptations: probing the epigenetic nexus. 
  • Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. 
  • Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. 
  • Edematous severe acute malnutrition is characterized by hypomethylation of DNA. 
  • Editing the Epigenome: Reshaping the Genomic Landscape. 
  • Editing the epigenome: technologies for programmable transcription and epigenetic modulation. 
  • Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. 
  • Epigenetic determinants of ovarian clear cell carcinoma biology. 
  • Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. 
  • Epigenetics and autism spectrum disorder: A report of an autism case with mutation in H1 linker histone HIST1H1E and literature review. 
  • Epigenetics and psychostimulant addiction. 
  • Epigenetics in brain function. 
  • Epigenome characterization at single base-pair resolution. 
  • Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. 
  • Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. 
  • Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. 
  • Epigenome-wide association study of metabolic syndrome in African-American adults. 
  • Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma. 
  • Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. 
  • Epigenomics of centromere assembly and function. 
  • Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression. 
  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. 
  • Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. 
  • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 
  • Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative. 
  • Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes. 
  • Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer. 
  • Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. 
  • Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. 
  • Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research. 
  • Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. 
  • Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants. 
  • Integrated detection of natural antisense transcripts using strand-specific RNA sequencing data. 
  • Integrative functional genomic analysis of human brain development and neuropsychiatric risks. 
  • Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models. 
  • Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. 
  • Linking Genes to Cardiovascular Diseases: Gene Action and Gene-Environment Interactions. 
  • Linking short tandem repeat polymorphisms with cytosine modifications in human lymphoblastoid cell lines. 
  • Main principles and outcomes of DNA methylation analysis. 
  • Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. 
  • Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study. 
  • Metabolic regulation of epigenetic remodeling in immune cells. 
  • Methylation subtypes and large-scale epigenetic alterations in gastric cancer. 
  • Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • Opportunities-and hard work-ahead. 
  • Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03). 
  • Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. 
  • Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. 
  • The BLUEPRINT Data Analysis Portal. 
  • The DNA methylation landscape of advanced prostate cancer. 
  • The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association. 
  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. 
  • The NIEHS TaRGET II Consortium and environmental epigenomics. 
  • The birth of the Epitranscriptome: deciphering the function of RNA modifications. 
  • The genetic regulatory signature of type 2 diabetes in human skeletal muscle. 
  • The impact of cellular metabolism on chromatin dynamics and epigenetics. 
  • The myth of genetic enhancement. 
  • Understanding risk for psychopathology through imaging gene-environment interactions. 
  • Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bilbo, Staci D., Professor of Psychology and Neuroscience, Psychology and Neuroscience
  • Liu, Yongmei, Professor of Medicine, Medicine, Cardiology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Tung, Jenny, Associate Professor of Evolutionary Anthropology, Duke Science & Society
  • Yan, Hai, Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine, Pathology