Hydrophobic and Hydrophilic Interactions
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Subject Areas on Research
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1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site.
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A Hierarchical Nanoparticle-in-Micropore Architecture for Enhanced Mechanosensitivity and Stretchability in Mechanochromic Electronic Skins.
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A fine line between molecular umbrella transport and ionophoric activity.
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A strong effect of AT mutational bias on amino acid usage in Buchnera is mitigated at high-expression genes.
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Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs.
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Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung.
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Amphiphilic α-helical potential: a putative folding motif adding few constraints to protein evolution.
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An inner activation gate controls TMEM16F phospholipid scrambling.
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Anti-infective biomaterials with surface-decorated tachyplesin I.
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Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions.
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Bilayers as protein solvents: role of bilayer structure and elastic properties.
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Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.
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Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications.
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Boronic acid porphyrin receptor for ginsenoside sensing.
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Bottom up design of nanoparticles for anti-cancer diapeutics: "put the drug in the cancer's food".
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Caging metal ions with visible light-responsive nanopolymersomes.
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Calcium binding peptide motifs from calmodulin confer divalent ion selectivity to elastin-like polypeptides.
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Cell wall mannan and cell surface hydrophobicity in Candida albicans serotype A and B strains.
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Characterization of surface hydrophobicity of engineered nanoparticles.
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Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with 57Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors.
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Chemisorptions of bacterial receptors for hydrophobic amino acids and sugars on gold for biosensor applications: a surface plasmon resonance study of genetically engineered proteins.
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Comparison of Hydrophilicity and Mechanical Properties of Nanocomposite Membranes with Cellulose Nanocrystals and Carbon Nanotubes.
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Computational design of receptor and sensor proteins with novel functions.
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Consequences of water between two hydrophobic surfaces on adhesion and wetting.
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Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes.
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Contribution of cell surface hydrophobicity protein 1 (Csh1p) to virulence of hydrophobic Candida albicans serotype A cells.
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Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils.
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Crystal structure of the MOP flippase MurJ in an inward-facing conformation.
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Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy.
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Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants.
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Effects of humic acid and electrolytes on photocatalytic reactivity and transport of carbon nanoparticle aggregates in water.
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Elastin-like polypeptides as models of intrinsically disordered proteins.
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Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation.
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Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation.
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Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.
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Evaluating the bioaccessibility of flame retardants in house dust using an in vitro Tenax bead-assisted sorptive physiologically based method.
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Functional polymer brushes via surface-initiated atom transfer radical graft polymerization for combating marine biofouling.
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Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
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Gravity-induced coating flows of vaginal gel formulations: in vitro experimental analysis.
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Harnessing localized ridges for high-aspect-ratio hierarchical patterns with dynamic tunability and multifunctionality.
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High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.
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High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain.
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Hydration and conformational mechanics of single, end-tethered elastin-like polypeptides.
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Hydration layer coupling and cooperativity in phase behavior of stimulus responsive peptide polymers.
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Hydrogen bonding of beta-turn structure is stabilized in D(2)O.
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Hydrophobic interactions increase attachment of gum Arabic- and PVP-coated Ag nanoparticles to hydrophobic surfaces.
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Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.
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Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
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Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates.
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In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.
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Intrinsically disordered proteins access a range of hysteretic phase separation behaviors.
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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
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Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct.
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Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
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Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
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Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.
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Long-term toughness of photopolymerizable (meth)acrylate networks in aqueous environments.
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Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function.
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Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
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Molecular description of the LCST behavior of an elastin-like polypeptide.
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Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.
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Molecular umbrella-amphotericin B conjugates.
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Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.
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Multifunctionality and control of the crumpling and unfolding of large-area graphene.
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Nanoscale structures and mechanics of barnacle cement.
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Noncanonical self-assembly of highly asymmetric genetically encoded polypeptide amphiphiles into cylindrical micelles.
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Optimal specificity and function for flexible biomolecular recognition.
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Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
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Persulfated molecular umbrellas as anti-HIV and anti-HSV agents.
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Phase Behavior and Self-Assembly of Perfectly Sequence-Defined and Monodisperse Multiblock Copolypeptides.
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Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates.
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Predicting transition temperatures of elastin-like polypeptide fusion proteins.
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Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH.
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Real-time heterogeneous protein-protein interaction between αA-crystallin N-terminal mutants and αB-crystallin using quartz crystal microbalance (QCM).
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Recent advances in nanoparticle-mediated siRNA delivery.
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Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs.
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Relationship between expression of cell surface hydrophobicity protein 1 (CSH1p) and surface hydrophobicity properties of Candida dubliniensis.
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Salt Responsive Morphologies of ssDNA-Based Triblock Polyelectrolytes in Semi-Dilute Regime: Effect of Volume Fractions and Polyelectrolyte Length.
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Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation.
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Sediment challenge to promising ultra-low fouling hydrophilic surfaces in the marine environment.
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Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation.
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Self-cleaning of superhydrophobic surfaces by self-propelled jumping condensate.
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Similarities between inorganic sulfide and the strong Hg(II)-complexing ligands in municipal wastewater effluent.
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Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression.
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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.
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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation.
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Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.
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Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant.
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Statistical estimation of statistical mechanical models: helix-coil theory and peptide helicity prediction.
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Strong hg(II) complexation in municipal wastewater effluent and surface waters.
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Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex.
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Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.
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Structural basis for an unexpected mode of SERM-mediated ER antagonism.
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Structural mechanisms of QacR induction and multidrug recognition.
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Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking.
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Surface hydrophobicity changes of two Candida albicans serotype B mnn4delta mutants.
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Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients.
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Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery.
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Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide.
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TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity.
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The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles.
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The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.
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The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size.
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The effect of packing hydrophilization on bacterial attachment and the relationship with the performance of biotrickling filters.
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The effect of surface contact activation and temperature on plasma coagulation with an RNA aptamer directed against factor IXa.
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The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.
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The relationship of physicochemical properties to the antioxidative activity of free amino acids in Fenton system.
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Thermally responsive polymeric micellar nanoparticles self-assembled from cholesteryl end-capped random poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): synthesis, temperature-sensitivity, and morphologies.
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Titanium surface characteristics, including topography and wettability, alter macrophage activation.
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Transport and retention of selected engineered nanoparticles by porous media in the presence of a biofilm.
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Two-faced cyclins with eyes on the targets.
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Ultrafast excited-state dynamics of nanoscale near-infrared emissive polymersomes.
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Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes.
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Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.
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Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer.
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Keywords of People
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Driehuys, Bastiaan,
Professor of Radiology,
Biomedical Engineering
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Hsu-Kim, Heileen,
Sternberg Family Professor of Civil & Environmental Engineering,
Civil and Environmental Engineering
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Katz, David F.,
Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering,
Biomedical Engineering
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Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Immunology
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Oas, Terrence Gilbert,
Professor of Biochemistry,
Biochemistry
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Warner, David Samuel,
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine,
Neurobiology