Septins

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  Subject Areas on Research

  • A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. 
  • Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. 
  • Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions. 
  • Dynamics of septin ring and collar formation in Saccharomyces cerevisiae. 
  • Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast. 
  • Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. 
  • Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. 
  • Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. 
  • NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1.2018. 
  • New insights into the phylogenetic distribution and evolutionary origins of the septins. 
  • Planar cell polarity acts through septins to control collective cell movement and ciliogenesis. 
  • Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering. 
  • Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. 
  • The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. 
  • The nonopisthokont septins: How many there are, how little we know about them, and how we might learn more. 
  • Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. 
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  Keywords of People

  • Lee, Walter T, Associate Professor of Head and Neck Surgery and Communication Sciences, Radiation Oncology
  • Lew, Daniel Julio, James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Cell Biology