Septins

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  Subject Areas on Research

  • A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. 
  • A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. 
  • Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. 
  • Dynamics of septin ring and collar formation in Saccharomyces cerevisiae. 
  • Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast. 
  • Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. 
  • Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. 
  • New insights into the phylogenetic distribution and evolutionary origins of the septins. 
  • Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering. 
  • Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. 
  • Temporal regulation of morphogenetic events in Saccharomyces cerevisiae. 
  • The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. 
  • The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri. 
  • The nonopisthokont septins: How many there are, how little we know about them, and how we might learn more. 
  • Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. 
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  Keywords of People

  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Lew, Daniel Julio, James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Cell Biology