Sumoylation
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Subject Areas on Research
- Cardiovascular biology: heart fails without pump partner.
- Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.
- Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration.
- In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes.
- Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
- Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
- Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses.
- Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
- Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.
- SENP3-mediated host defense response contains HBV replication and restores protein synthesis.
- SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases.
- SUMO2/3 conjugation is an endogenous neuroprotective mechanism.
- SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ.
- SUMOylation in brain ischemia: Patterns, targets, and translational implications.
- SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein.
- Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.
- T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.
- Targeting the SUMO pathway for neuroprotection in brain ischaemia.
- The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications.
- Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.