Sumoylation
-
Subject Areas on Research
- Cardiovascular biology: heart fails without pump partner.
- Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.
- Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration.
- Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
- Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses.
- Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
- SENP3-mediated host defense response contains HBV replication and restores protein synthesis.
- SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases.
- SUMO2/3 conjugation is an endogenous neuroprotective mechanism.
- SUMOylation in brain ischemia: Patterns, targets, and translational implications.
- Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.
- Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.
- T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.
- Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.