Cardiac Resynchronization Therapy

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  Subject Areas on Research

  • 2012 ACCF/AHA/HRS focused update of the 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 
  • 2015 ACC/AHA/HRS guideline for the management of adult patients with supraventricular tachycardia: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • 2015 ACC/AHA/HRS guideline for the management of adult patients with supraventricular tachycardia: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing. 
  • 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society. 
  • 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • ACCF/HRS/AHA/ASE/HFSA/SCAI/SCCT/SCMR 2013 appropriate use criteria for implantable cardioverter-defibrillators and cardiac resynchronization therapy: a report of the American College of Cardiology Foundation appropriate use criteria task force, Heart Rhythm Society, American Heart Association, American Society of Echocardiography, Heart Failure Society of America, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. 
  • ACCF/HRS/AHA/ASE/HFSA/SCAI/SCCT/SCMR 2013 appropriate use criteria for implantable cardioverter-defibrillators and cardiac resynchronization therapy: a report of the American College of Cardiology Foundation appropriate use criteria task force, Heart Rhythm Society, American Heart Association, American Society of Echocardiography, Heart Failure Society of America, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. 
  • Are racial/ethnic gaps in the use of cardiac resynchronization therapy narrowing?: an analysis of 107,096 patients from the National Cardiovascular Data Registry's ICD Registry. 
  • Arrhythmias in Female Patients: Incidence, Presentation and Management. 
  • Arrhythmic Burden and the Risk of Cardiovascular Outcomes in Patients With Paroxysmal Atrial Fibrillation and Cardiac Implanted Electronic Devices. 
  • Arrhythmic and Mortality Outcomes Among Ischemic Versus Nonischemic Cardiomyopathy Patients Receiving Primary ICD Therapy. 
  • Assessing mitral regurgitation in the prediction of clinical outcome after cardiac resynchronization therapy. 
  • Association Between a Prolonged PR Interval and Outcomes of Cardiac Resynchronization Therapy: A Report From the National Cardiovascular Data Registry. 
  • Association between frequency of atrial and ventricular ectopic beats and biventricular pacing percentage and outcomes in patients with cardiac resynchronization therapy. 
  • Association between left ventricular ejection fraction post-cardiac resynchronization treatment and subsequent implantable cardioverter defibrillator therapy for sustained ventricular tachyarrhythmias. 
  • Association between myocardial substrate, implantable cardioverter defibrillator shocks and mortality in MADIT-CRT. 
  • Association between vectorcardiographic QRS area and incident heart failure diagnosis and mortality among patients with left bundle branch block: A register-based cohort study. 
  • Association of Implantable Device Measured Physical Activity With Hospitalization for Heart Failure. 
  • Atrioventricular and ventricular-to-ventricular programming in patients with cardiac resynchronization therapy: results from ALTITUDE. 
  • Beyond pharmacological treatment: an insight into therapies that target specific aspects of heart failure pathophysiology. 
  • Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort. 
  • Cardiac Resynchronization Therapy With or Without Defibrillation in Patients With Nonischemic Cardiomyopathy: A Systematic Review and Meta-Analysis. 
  • Cardiac Resynchronization Therapy in the Autumn of Life. 
  • Cardiac contractility modulation: the next cardiac resynchronization therapy or another renal sympathetic denervation? 
  • Cardiac resynchronization therapy in chronic heart failure with moderately reduced left ventricular ejection fraction: Lessons from the Multicenter InSync Randomized Clinical Evaluation MIRACLE EF study. 
  • Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction. 
  • Cardiac resynchronization therapy in patients with renal dysfunction: keep calm and carry on. 
  • Cardiac resynchronization therapy outcomes with left ventricular lead concordant with latest mechanical activation: A meta-analysis. 
  • Cardiac resynchronization therapy: Identifying an activation delay by regional strain analysis. 
  • Change in intrathoracic impedance measures during acute decompensated heart failure admission: results from the Diagnostic Data for Discharge in Heart Failure Patients (3D-HF) Pilot Study. 
  • Changes in the optimal cardiac resynchronization therapy pacing configuration during physiologic stress. 
  • Choosing a particular oral anticoagulant and dose for stroke prevention in individual patients with non-valvular atrial fibrillation: part 1. 
  • Clinical Heart Failure Among Patients With and Without Severe Mental Illness and the Association With Long-Term Outcomes. 
  • Clinical effectiveness of CRT and ICD therapy in heart failure patients by racial/ethnic classification: insights from the IMPROVE HF registry. 
  • Clinical effectiveness of cardiac resynchronization and implantable cardioverter-defibrillator therapy in men and women with heart failure: findings from IMPROVE HF. 
  • Clinical effectiveness of cardiac resynchronization therapy versus medical therapy alone among patients with heart failure: analysis of the ICD Registry and ADHERE. 
  • Comparative Effectiveness of CRT-D Versus Defibrillator Alone in HF Patients With Moderate-to-Severe Chronic Kidney Disease. 
  • Comparative Effectiveness of Cardiac Resynchronization Therapy Among Patients With Heart Failure and Atrial Fibrillation: Findings From the National Cardiovascular Data Registry's Implantable Cardioverter-Defibrillator Registry. 
  • Comparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study. 
  • Comparison of dyssynchrony parameters for VV-optimization in CRT patients. 
  • Complications and Mortality Following CRT-D Versus ICD Implants in Older Medicare Beneficiaries With Heart Failure. 
  • Concomitant changes in ventricular depolarization and repolarization and long-term outcomes of biventricular pacing. 
  • Continuous Monitoring of Heart Rate Variability and Clinical Outcomes in Patients with Implantable Cardioverter Defibrillators. 
  • Current evidence on treatment of patients with chronic systolic heart failure and renal insufficiency: practical considerations from published data. 
  • Decision making in advanced heart failure: a scientific statement from the American Heart Association. 
  • Defibrillators: Selecting the Right Device for the Right Patient. 
  • Development of a method to risk stratify patients with heart failure for 30-day readmission using implantable device diagnostics. 
  • Device therapy in heart failure patients with chronic kidney disease. 
  • Does Age Influence Cardiac Resynchronization Therapy Use and Outcome? 
  • Dyssynchrony: a different kind of mitral regurgitation. 
  • Effect of cardiac resynchronization therapy and implantable cardioverter defibrillator on quality of life in patients with heart failure: a meta-analysis. 
  • Effect of defibrillation threshold testing on heart failure hospitalization or death in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). 
  • Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). 
  • Electrophysiology in China: a special supplement. Introduction. 
  • Emerging Implantable-Device Technology for Patients at the Intersection of Electrophysiology and Heart Failure Interdisciplinary Care. 
  • Evaluating strict and conventional left bundle branch block criteria using electrocardiographic simulations. 
  • Exercise training and pacing status in patients with heart failure: results from HF-ACTION. 
  • Extent of and reasons for nonuse of implantable cardioverter defibrillator devices in clinical practice among eligible patients with left ventricular systolic dysfunction. 
  • Factors associated with improvement in utilization of cardiac resynchronization therapy in eligible heart failure patients: findings from IMPROVE HF. 
  • Feasibility of a Randomized Clinical Trial of Cardiac Resynchronization Therapy With or Without an Implantable Defibrillator in Older Patients. 
  • Follow-up of patients with new cardiovascular implantable electronic devices: are experts' recommendations implemented in routine clinical practice? 
  • Follow-up of patients with new cardiovascular implantable electronic devices: is adherence to the experts' recommendations associated with improved outcomes? 
  • Future research prioritization in cardiac resynchronization therapy. 
  • Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT-RIT substudy. 
  • Heart Failure and Atrial Fibrillation, Like Fire and Fury. 
  • How to Implant Cardiac Resynchronization Therapy in a Busy Clinical Practice. 
  • ICDs Are Still an Effective Therapy to Prevent Sudden Cardiac Death in Heart Failure. 
  • INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) Profiling Identifies Ambulatory Patients at High Risk on Medical Therapy After Hospitalizations for Heart Failure. 
  • Identification of Typical Left Bundle Branch Block Contraction by Strain Echocardiography Is Additive to Electrocardiography in Prediction of Long-Term Outcome After Cardiac Resynchronization Therapy. 
  • Impact of Current Versus Previous Cardiac Resynchronization Therapy Guidelines on the Proportion of Patients With Heart Failure Eligible for Therapy. 
  • Impact of physiologic pacing versus right ventricular pacing among patients with left ventricular ejection fraction greater than 35%: A systematic review for the 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • Impact of remote monitoring on clinical events and associated health care utilization: A nationwide assessment. 
  • Incidence and predictors of implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergoing implantable cardioverter-defibrillator implantation for primary prevention. 
  • Index of contractile asymmetry improves patient selection for CRT: a proof-of-concept study. 
  • Indications for cardiac resynchronization therapy: 2011 update from the Heart Failure Society of America Guideline Committee. 
  • Integrated electrophysiology care for patients with heart failure: An envisioned future. 
  • Is Image Guidance for Left Ventricular Lead Targeting Overkill? 
  • Is cardiac resynchronization therapy an antiarrhythmic therapy for atrial fibrillation? A systematic review and meta-analysis. 
  • Is heart failure guideline adherence being underestimated? The impact of therapeutic contraindications. 
  • Lead one ratio in left bundle branch block predicts poor cardiac resynchronization therapy response. 
  • Left Bundle Branch Block: Is it "Unsafe at Any Speed"? 
  • Left bundle branch block predicts better survival in women than men receiving cardiac resynchronization therapy: long-term follow-up of ∼ 145,000 patients. 
  • Left bundle branch block without a typical contraction pattern is associated with increased risk of ventricular arrhythmias in cardiac resynchronization therapy patients. 
  • Left bundle branch block-induced left ventricular remodeling and its potential for reverse remodeling. 
  • Left bundle-branch block is associated with asimilar dyssynchronous phenotype in heart failure patients with normal and reduced ejection fractions. 
  • Left bundle-branch block: the relationship between electrocardiogram electrical activation and echocardiography mechanical contraction. 
  • Left ventricular lead position and clinical outcome in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT) trial. 
  • Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs nonstrict electrocardiogram criteria for left bundle-branch block. 
  • Lessons learned from clinical trials in acute heart failure: phase 3 drug trials. 
  • Machine Learning Algorithm Predicts Cardiac Resynchronization Therapy Outcomes: Lessons From the COMPANION Trial. 
  • Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy. 
  • Medical Management of Heart Failure With Reduced Ejection Fraction in Patients With Advanced Renal Disease. 
  • Modeling defibrillation benefit for survival among cardiac resynchronization therapy defibrillator recipients. 
  • More bad news for cardiac resynchronization therapy in atrial fibrillation patients: what to do? 
  • Multiple Comorbidities and Response to Cardiac Resynchronization Therapy: MADIT-CRT Long-Term Follow-Up. 
  • Multiple cArdiac seNsors for mAnaGEment of Heart Failure (MANAGE-HF) - Phase I Evaluation of the Integration and Safety of the HeartLogic Multisensor Algorithm in Patients With Heart Failure. 
  • Myocardial scar in sarcoidosis by 12-lead ECG and pathology. 
  • Navigating Choices Among a Sea of Comorbidities. 
  • Non-invasively quantified changes in left ventricular activation predict outcomes in patients undergoing cardiac resynchronization therapy. 
  • Optimal utilization and management of implanted cardiac rhythm devices in patients hospitalized for heart failure. 
  • Oral anticoagulation management in patients with atrial fibrillation undergoing cardiac implantable electronic device implantation. 
  • Outcomes associated with warfarin use in older patients with heart failure and atrial fibrillation and a cardiovascular implantable electronic device: findings from the ADHERE registry linked to Medicare claims. 
  • Outcomes of Cardiac Resynchronization Therapy with Image-Guided Left Ventricular Lead Placement at the Site of Latest Mechanical Activation: A Systematic Review and Meta-Analysis. 
  • PR Prolongation predicts inadequate resynchronization with biventricular pacing in left bundle branch block. 
  • PR interval identifies clinical response in patients with non-left bundle branch block: a Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy substudy. 
  • Performance of a novel active fixation quadripolar left ventricular lead for cardiac resynchronization therapy: Attain Stability Quad Clinical Study results. 
  • Postimplantation ventricular ectopic burden and clinical outcomes in cardiac resynchronization therapy-defibrillator patients: a MADIT-CRT substudy. 
  • Predicted benefit of an implantable cardioverter-defibrillator: the MADIT-ICD benefit score. 
  • Predictors of sustained ventricular arrhythmias in cardiac resynchronization therapy. 
  • Prescription of Guideline-Recommended Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy Among Patients Hospitalized With Heart Failure and Varying Degrees of Renal Function. 
  • Presence of mechanical dyssynchrony in Duchenne muscular dystrophy. 
  • Progressive ventricular dysfunction among nonresponders to cardiac resynchronization therapy: baseline predictors and associated clinical outcomes. 
  • Prolonged QRS in Heart Failure With Preserved Ejection Fraction: Risk Marker and Therapeutic Target? 
  • QRS duration, bundle-branch block morphology, and outcomes among older patients with heart failure receiving cardiac resynchronization therapy. 
  • QRS fusion complex analysis using wave interference to predict reverse remodeling during cardiac resynchronization therapy. 
  • Racial/ethnic differences in atrial fibrillation symptoms, treatment patterns, and outcomes: Insights from Outcomes Registry for Better Informed Treatment for Atrial Fibrillation Registry. 
  • Rationale and design of the GUIDE-IT study: Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure. 
  • Relationship Between Electrical and Mechanical Dyssynchrony and Outcomes Among Patients Undergoing Cardiac Resynchronization Therapy. 
  • Remote monitoring of cardiac implantable electronic devices (CIED). 
  • Renal Response in Patients with Chronic Kidney Disease Predicts Outcome Following Cardiac Resynchronization Therapy. 
  • Reply: Complications and Mortality Following CRT-D vs ICD. 
  • Reply: Early Cardiac Resynchronization Therapy for Left Bundle Branch Block-Associated Cardiomyopathies. 
  • Reply: Echocardiographic Substrate for Biventricular Pacing. 
  • Reply: The Benefit of Cardiac Resynchronization Therapy Is Not Hindered by the Number of Comorbidities. 
  • Response to letter regarding, "PR interval identifies clinical response in patients with non-left bundle branch block: a multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy sub-study" by Kutyifa et al. 
  • Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT. 
  • Return on Investment in Implantable Devices: Cardiac Resynchronization Therapy in Mildly Symptomatic Heart Failure. 
  • Review of advanced heart failure device diagnostics examined in clinical trials and the potential benefit from monitoring capabilities. 
  • Right ventricular lead location and outcomes among patients with cardiac resynchronization therapy: A meta-analysis. 
  • Risk stratification for arrhythmic events in patients with asymptomatic pre-excitation: A systematic review for the 2015 ACC/AHA/HRS guideline for the management of adult patients with supraventricular tachycardia: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony. 
  • Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study. 
  • Segment Length in Cine Strain Analysis Predicts Cardiac Resynchronization Therapy Outcome Beyond Current Guidelines. 
  • Sex Differences in Inappropriate ICD Device Therapies: MADIT-II and MADIT-CRT. 
  • Sex-Specific Differences in Heart Failure: Pathophysiology, Risk Factors, Management, and Outcomes. 
  • Should His Bundle Pacing Be Preferred over Cardiac Resynchronization Therapy Following Atrioventricular Junction Ablation? 
  • Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages. 
  • Size Matters: Normalization of QRS Duration to Left Ventricular Dimension Improves Prediction of Long-Term Cardiac Resynchronization Therapy Outcome. 
  • Spinal cord stimulation for intercostal neuralgia in a patient with implantable cardiac defibrillator and biventricular pacing. 
  • Standardized definitions for evaluation of heart failure therapies: scientific expert panel from the Heart Failure Collaboratory and Academic Research Consortium. 
  • Survival in Women Versus Men Following Implantation of Pacemakers, Defibrillators, and Cardiac Resynchronization Therapy Devices in a Large, Nationwide Cohort. 
  • Survival with cardiac-resynchronization therapy in mild heart failure. 
  • Technologist Corner: Value of radionuclide ventriculography to assess mechanical dyssynchrony and predict the cardiac resynchronization therapy response. 
  • The Association of a classical left bundle Branch Block Contraction Pattern by vendor-independent strain echocardiography and outcome after cardiac resynchronization therapy. 
  • The ECG Belt for CRT response trial: Design and clinical protocol. 
  • The Relationship Between Level of Adherence to Automatic Wireless Remote Monitoring and Survival in Pacemaker and Defibrillator Patients. 
  • The Role for Cardiovascular Remodeling in Cardiovascular Outcomes. 
  • The anatomic and electrical location of the left ventricular lead predicts ventricular arrhythmia in cardiac resynchronization therapy. 
  • The association between biventricular pacing and cardiac resynchronization therapy-defibrillator efficacy when compared with implantable cardioverter defibrillator on outcomes and reverse remodelling. 
  • The economics of heart failure. 
  • The effect of intermittent atrial tachyarrhythmia on heart failure or death in cardiac resynchronization therapy with defibrillator versus implantable cardioverter-defibrillator patients: a MADIT-CRT substudy (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy). 
  • The efficacy and safety of cardiac resynchronization therapy combined with implantable cardioverter defibrillator for heart failure: a meta-analysis of 5674 patients. 
  • The electromechanical substrate for response to cardiac resynchronization therapy in patients with right bundle branch block. 
  • The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. 
  • The mechanical and hemodynamic effects of left ventricular pacing in heart failure with preserved ejection fraction and left bundle branch block. 
  • The role of cardiac MR in new-onset heart failure. 
  • Time-dependent risk reduction of ventricular tachyarrhythmias in cardiac resynchronization therapy patients: a MADIT-RIT sub-study. 
  • Timing of cardiac resynchronization therapy device implantation in heart failure patients and its association with outcomes. 
  • Usefulness and consequences of cardiac resynchronization therapy in dialysis-dependent patients with heart failure. 
  • Utility of diastolic dyssynchrony in the setting of cardiac resynchronization therapy. 
  • Utilization of cardiac resynchronization therapy in eligible patients hospitalized for heart failure and its association with patient outcomes. 
  • Vectorcardiographic QRS area is associated with long-term outcome after cardiac resynchronization therapy. 
  • Venoplasty and Stenting. 
  • Ventricular Pacing in Single Ventricle Circulation: Making the Best of a Difficult Situation. 
  • When Is It Safe Not to Reimplant an Implantable Cardioverter Defibrillator at the Time of Battery Depletion? 
  • Why the Authors Use Cardiac Resynchronization Therapy with Defibrillators. 
  • Why the Authors Use Cardiac Resynchronization Therapy with Defibrillators. 
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  Keywords of People

  • Carboni, Michael Paul, Associate Professor of Pediatrics, Pediatrics, Cardiology
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Friedman, Daniel, Assistant Professor of Medicine, Medicine, Cardiology
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology