Receptors, Purinergic P2X7
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Subject Areas on Research
- Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18.
- Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.
- Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD.
- Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow.
- P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels.
- P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.
- Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis.
- Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis.
- Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans.