Drug Repositioning
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Subject Areas on Research
- A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization.
- A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease.
- Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
- Characteristics of Clinical Studies Used for US Food and Drug Administration Supplemental Indication Approvals of Drugs and Biologics, 2017 to 2019.
- Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials.
- Copper is required for oncogenic BRAF signalling and tumorigenesis.
- Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
- Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
- Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.
- Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval.
- Genomics-enabled drug repositioning and repurposing: insights from an IOM Roundtable activity.
- Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus.
- In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.
- KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway.
- Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model.
- Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors.
- New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.
- Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential.
- Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection.
- Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.
- Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer.
- Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.
- Use Patents Can Be Useful: The Case of Rescued Drugs
- Using "old" medications to fight new COVID-19: Re-purposing with a purpose.
- β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19.