Class I Phosphatidylinositol 3-Kinases
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Subject Areas on Research
- AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
- Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.
- Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum.
- Comprehensive molecular portraits of human breast tumours.
- Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.
- Genetic heterogeneity of diffuse large B-cell lymphoma.
- High frequency of mutations of the PIK3CA gene in human cancers.
- Leukaemia hijacks a neural mechanism to invade the central nervous system.
- Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases.
- Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.
- Novel mutations target distinct subgroups of medulloblastoma.
- Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
- PIK3CA mutation in a mixed dysembryoplastic neuroepithelial tumor and rosette forming glioneuronal tumor, a case report and literature review.
- PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
- PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.
- Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial.
- Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex.
- Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
- The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.