TOR Serine-Threonine Kinases
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Subject Areas on Research
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A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.
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A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation.
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A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer.
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A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer.
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A phase Ib study of combined VEGFR and mTOR inhibition with vatalanib and everolimus in patients with advanced renal cell carcinoma.
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A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.
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A systematic review of sequencing and combinations of systemic therapy in metastatic renal cancer.
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A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
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AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
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AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes.
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ATM functions at the peroxisome to induce pexophagy in response to ROS.
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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
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Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis.
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Activity of single-agent bevacizumab in patients with metastatic renal cell carcinoma previously treated with vascular endothelial growth factor tyrosine kinase inhibitors.
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Akt-dependent and -independent mechanisms of mTOR regulation in cancer.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
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An animal model of MYC-driven medulloblastoma.
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An expanded role of the tumor suppressor TSC1 in T cell tolerance.
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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.
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Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.
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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
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Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
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Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
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Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.
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Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.
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Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
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BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma--A Trial of the ECOG-ACRIN Cancer Research Group (E2804).
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BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
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Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin.
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Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma.
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Big or fast: two strategies in the developmental control of body size.
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Biological Role and Therapeutic Potential of IDH Mutations in Cancer.
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Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae.
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Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.
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Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.
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Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.
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Cardiometabolic Consequences of Targeted Anticancer Therapies.
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Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
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Cell signaling modifiers in prostate cancer.
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Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy.
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Challenges and Emerging Opportunities for Targeting mTOR in Cancer.
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Charting the landscape of tandem BRCT domain-mediated protein interactions.
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Clinical activity of mammalian target of rapamycin inhibitors in solid tumors.
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Clinical outcomes in kidney transplant recipients receiving long-term therapy with inhibitors of the mammalian target of rapamycin.
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Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.
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Coming of age: molecular drivers of aging and therapeutic opportunities.
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Comprehensive molecular characterization of urothelial bladder carcinoma.
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Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
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Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer.
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Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.
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Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
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Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.
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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
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DTRMWXHS-12, a novel Bruton tyrosine kinase inhibitor, in combination with everolimus and pomalidomide in patients with relapsed/refractory lymphomas: An open-label, multicenter, phase 1a/1b study.
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Decreased autophagy and fuel switching occur in a senescent hepatic cell model system.
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Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.
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Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
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Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
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Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.
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Direct Evidence of Target Inhibition with Anti-VEGF, EGFR, and mTOR Therapies in a Clinical Model of Wound Healing.
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Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.
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Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature.
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Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
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Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.
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Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing.
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ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.
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Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.
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Effects of spaceflight on murine skeletal muscle gene expression.
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Efficacy and safety of mammalian target of rapamycin inhibitors following intestinal and multivisceral transplantation.
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Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
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Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
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Everolimus in colorectal cancer.
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Everolimus tablets for patients with subependymal giant cell astrocytoma.
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Everolimus to treat aggressive retinal astrocytic hamartoma in tuberous sclerosis complex.
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Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
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Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.
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Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
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Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
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Functional variant of MTOR rs2536 and survival of Chinese gastric cancer patients.
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Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population.
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Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.
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Growth signaling at the nexus of stem cell life and death.
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Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway.
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Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
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Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation.
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IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates.
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IL-7 enhances the survival and maintains the size of naive T cells.
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Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.
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Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil.
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Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy?
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Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
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Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons.
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Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency.
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Influenza vaccines: mTOR inhibition surprisingly leads to protection.
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Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension.
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Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.
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Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies.
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Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
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Inhibitors of mTOR and risks of allograft failure and mortality in kidney transplantation.
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Initial testing (stage 1) of the investigational mTOR kinase inhibitor MLN0128 by the pediatric preclinical testing program.
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Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program.
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Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.
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Ipatasertib, an oral AKT inhibitor, in combination with carboplatin exhibits anti-proliferative effects in uterine serous carcinoma.
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KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
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L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome.
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LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin.
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Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity.
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Longevity-related molecular pathways are subject to midlife "switch" in humans.
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MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch.
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MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy.
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MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.
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Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.
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Mammalian target of rapamycin inhibition.
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Management of adverse events associated with idelalisib treatment: expert panel opinion.
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Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.
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Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.
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Metastatic breast cancer, version 1.2012: featured updates to the NCCN guidelines.
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Metformin prevents tobacco carcinogen--induced lung tumorigenesis.
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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
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Microscaled proteogenomic methods for precision oncology.
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Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
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Modulation of Xenogeneic T-cell Proliferation by B7 and mTOR Blockade of T Cells and Porcine Endothelial Cells.
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Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
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Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy.
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Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
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Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK.
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NCCN Task Force Report: mTOR inhibition in solid tumors.
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Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.
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Negative regulation of mTOR activation by diacylglycerol kinases.
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Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors.
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Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.
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On the Discovery of TOR As the Target of Rapamycin.
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PAK1 mediates resistance to PI3K inhibition in lymphomas.
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PI3K/mTOR Dual Inhibitor, LY3023414, Demonstrates Potent Antitumor Efficacy Against Esophageal Adenocarcinoma in a Rat Model.
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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
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PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
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PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers.
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PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
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PTEN hamartoma tumor syndromes.
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Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer.
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Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
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Polymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations.
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Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.
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Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.
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Proteinuria causes dysfunctional autophagy in the proximal tubule.
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Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells.
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Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.
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Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M.
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Receptor signaling in immune cell development and function.
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Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
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Regulation of T-cell survival and mitochondrial homeostasis by TSC1.
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Regulation of mast cell survival and function by tuberous sclerosis complex 1.
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Reply to M A Khattak et al.
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Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
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Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy.
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Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
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Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin.
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Skeletal muscle mass recovery from atrophy in IL-6 knockout mice.
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Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy.
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Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
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Somatic variants in diverse genes leads to a spectrum of focal cortical malformations.
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Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.
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Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
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Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.
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Systemic Therapy for Non-Clear Cell Renal Cell Carcinoma.
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Systemic therapy for advanced soft tissue sarcomas: highlighting novel therapies and treatment approaches.
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T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
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TGF-beta: a new role for an old AktTOR.
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TRPC1 channels are critical for hypertrophic signaling in the heart.
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TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.
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Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer.
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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.
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Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
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The Evolving Complexity of Treating Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer: Special Considerations in Older Breast Cancer Patients-Part II: Metastatic Disease.
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The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.
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The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion.
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The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas.
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The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.
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The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.
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The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
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The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation.
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The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse.
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The role and regulation of mTOR in T-lymphocyte function.
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The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
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The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy.
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The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
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The role of tuberous sclerosis complex 1 in regulating innate immunity.
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Therapeutic Benefit of Autophagy Modulation in Pompe Disease.
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Therapy for non-clear cell histologies in renal cancer.
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Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.
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Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.
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Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.
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Transcriptional and Immune Landscape of Cardiac Sarcoidosis.
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Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.
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Tumor suppressor TSC1 is critical for T-cell anergy.
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Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling.
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Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae.
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Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.
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iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
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mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
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mTOR and its tight regulation for iNKT cell development and effector function.
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mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.
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mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
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mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
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mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.
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mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.
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mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.
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mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.
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mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.
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mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.
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miR-19 is a key oncogenic component of mir-17-92.
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Keywords of People
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Buckley, Anne Frances,
Assistant Professor of Pathology,
Pathology
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Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Zhong, Xiaoping,
Professor of Pediatrics,
Integrative Immunobiology