Epithelial-Mesenchymal Transition

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  Subject Areas on Research

  • A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype. 
  • A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. 
  • Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling. 
  • Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. 
  • Adam10 is essential for early embryonic cardiovascular development. 
  • Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence. 
  • Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. 
  • Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis. 
  • An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines. 
  • An early cell shape transition drives evolutionary expansion of the human forebrain. 
  • Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors. 
  • Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression. 
  • Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. 
  • Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. 
  • BOO induces fibrosis and EMT in urothelial cells which can be recapitulated in vitro through elevated storage and voiding pressure cycles. 
  • Carcinosarcomas: tumors in transition? 
  • Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. 
  • Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition. 
  • Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma. 
  • Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition. 
  • Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. 
  • Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. 
  • Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling. 
  • Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate. 
  • Development of a method to isolate circulating tumor cells using mesenchymal-based capture. 
  • Dichotomous roles of TGF-β in human cancer. 
  • Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. 
  • E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms. 
  • E-cadherin in gastric carcinomas: Relations with histological parameters and its prognostic value. 
  • EMT Molecular Signatures of Pancreatic Neuroendocrine Neoplasms. 
  • EMT and MET: necessary or permissive for metastasis? 
  • Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells. 
  • Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. 
  • Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. 
  • Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk. 
  • Epithelial-mesenchymal transition in cancer progression. 
  • Epithelial-mesenchymal transition in prostate cancer: providing new targets for therapy. 
  • Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injury. 
  • Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. 
  • Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding? 
  • Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes. 
  • Evidence for and against epithelial-to-mesenchymal transition in the liver. 
  • Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. 
  • Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer. 
  • Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. 
  • Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment. 
  • Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo. 
  • Gastrulation in the sea urchin. 
  • Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot. 
  • Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. 
  • Guidelines and definitions for research on epithelial-mesenchymal transition. 
  • HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. 
  • Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia. 
  • Hedgehog signaling in the liver. 
  • Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers. 
  • Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas. 
  • ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer. 
  • Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition. 
  • Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells. 
  • Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity. 
  • Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. 
  • Ion mobility derived collision cross sections to support metabolomics applications. 
  • Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma. 
  • Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. 
  • LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. 
  • Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer. 
  • Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells. 
  • Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2. 
  • Methodologies for Following EMT In Vivo at Single Cell Resolution. 
  • Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition. 
  • Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. 
  • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. 
  • N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN. 
  • NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes. 
  • Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. 
  • Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer. 
  • Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model. 
  • Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype. 
  • Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis. 
  • Perspective on Epithelial-Mesenchymal Transitions in Embryos. 
  • Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse. 
  • Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. 
  • RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation. 
  • Role of TGF-β receptor III localization in polarity and breast cancer progression. 
  • Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade. 
  • SFPQ promotes an oncogenic transcriptomic state in melanoma. 
  • Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. 
  • Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. 
  • Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition. 
  • Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric. 
  • Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. 
  • TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion. 
  • TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology. 
  • The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer. 
  • The expression of Claudin-4 in gastric cancer tissue: A single center experience. 
  • The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma. 
  • The role of WNT10B in normal prostate gland development and prostate cancer. 
  • The role of epithelial plasticity in prostate cancer dissemination and treatment resistance. 
  • Toward understanding cancer stem cell heterogeneity in the tumor microenvironment. 
  • Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer. 
  • Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish. 
  • mRNA profiling of a well-differentiated G1 pancreatic NET correlates with immunohistochemistry profile: a case report. 
  • microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu). 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology