Epithelial-Mesenchymal Transition
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Subject Areas on Research
- A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype.
- A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model.
- Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling.
- Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.
- Adam10 is essential for early embryonic cardiovascular development.
- Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence.
- Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells.
- Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.
- An early cell shape transition drives evolutionary expansion of the human forebrain.
- Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors.
- Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.
- Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
- Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype.
- BOO induces fibrosis and EMT in urothelial cells which can be recapitulated in vitro through elevated storage and voiding pressure cycles.
- Carcinosarcomas: tumors in transition?
- Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells.
- Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition.
- Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition.
- Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers.
- Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.
- Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.
- Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate.
- Development of a method to isolate circulating tumor cells using mesenchymal-based capture.
- Dichotomous roles of TGF-β in human cancer.
- Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.
- E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.
- E-cadherin in gastric carcinomas: Relations with histological parameters and its prognostic value.
- EMT and MET: necessary or permissive for metastasis?
- Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells.
- Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC.
- Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
- Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.
- Epithelial-mesenchymal transition in cancer progression.
- Epithelial-mesenchymal transition in prostate cancer: providing new targets for therapy.
- Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.
- Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?
- Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.
- Evidence for and against epithelial-to-mesenchymal transition in the liver.
- Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
- Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion.
- Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment.
- Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo.
- Gastrulation in the sea urchin.
- Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.
- Guidelines and definitions for research on epithelial-mesenchymal transition.
- HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
- Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.
- Hedgehog signaling in the liver.
- Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers.
- Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas.
- ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.
- Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition.
- Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.
- Invasive prostate carcinoma driven by c-Src and androgen receptor synergy.
- Ion mobility derived collision cross sections to support metabolomics applications.
- Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.
- LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.
- Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer.
- Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells.
- Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.
- Methodologies for Following EMT In Vivo at Single Cell Resolution.
- Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition.
- Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.
- N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN.
- Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer.
- Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model.
- Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.
- Perspective on Epithelial-Mesenchymal Transitions in Embryos.
- Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse.
- Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells.
- Role of TGF-β receptor III localization in polarity and breast cancer progression.
- Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade.
- Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
- Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition.
- Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric.
- Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
- TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
- TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology.
- The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer.
- The expression of Claudin-4 in gastric cancer tissue: A single center experience.
- The role of WNT10B in normal prostate gland development and prostate cancer.
- The role of epithelial plasticity in prostate cancer dissemination and treatment resistance.
- Toward understanding cancer stem cell heterogeneity in the tumor microenvironment.
- Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.
- Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.
- mRNA profiling of a well-differentiated G1 pancreatic NET correlates with immunohistochemistry profile: a case report.
- microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu).
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Keywords of People
- Bachelder, Robin Elizabeth, Associate Professor in Surgery, Pathology
- Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
- Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
- McCall, Shannon Jones, Associate Professor of Pathology, Pathology