Epithelial-Mesenchymal Transition
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Subject Areas on Research
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A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype.
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A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model.
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Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling.
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Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.
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Adam10 is essential for early embryonic cardiovascular development.
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Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence.
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Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells.
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Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.
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An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines.
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An early cell shape transition drives evolutionary expansion of the human forebrain.
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Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors.
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Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.
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Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
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Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype.
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BOO induces fibrosis and EMT in urothelial cells which can be recapitulated in vitro through elevated storage and voiding pressure cycles.
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Carcinosarcomas: tumors in transition?
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Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells.
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Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition.
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Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
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Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition.
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Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers.
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Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.
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Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.
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Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate.
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Development of a method to isolate circulating tumor cells using mesenchymal-based capture.
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Dichotomous roles of TGF-β in human cancer.
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Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.
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E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.
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E-cadherin in gastric carcinomas: Relations with histological parameters and its prognostic value.
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EMT Molecular Signatures of Pancreatic Neuroendocrine Neoplasms.
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EMT and MET: necessary or permissive for metastasis?
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Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells.
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Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC.
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Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
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Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.
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Epithelial-mesenchymal transition in cancer progression.
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Epithelial-mesenchymal transition in prostate cancer: providing new targets for therapy.
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Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injury.
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Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.
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Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?
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Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.
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Evidence for and against epithelial-to-mesenchymal transition in the liver.
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Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
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Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer.
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Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion.
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Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment.
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Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo.
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Gastrulation in the sea urchin.
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Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot.
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Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.
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Guidelines and definitions for research on epithelial-mesenchymal transition.
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HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
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Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.
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Hedgehog signaling in the liver.
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Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers.
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Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas.
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ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.
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Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition.
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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.
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Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity.
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Invasive prostate carcinoma driven by c-Src and androgen receptor synergy.
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Ion mobility derived collision cross sections to support metabolomics applications.
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Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.
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Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.
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LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.
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Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer.
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Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells.
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Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.
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Methodologies for Following EMT In Vivo at Single Cell Resolution.
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Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition.
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Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.
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Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.
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N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN.
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NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes.
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Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
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Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer.
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Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model.
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Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype.
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Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.
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Perspective on Epithelial-Mesenchymal Transitions in Embryos.
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Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse.
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Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells.
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RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation.
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Role of TGF-β receptor III localization in polarity and breast cancer progression.
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Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade.
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SFPQ promotes an oncogenic transcriptomic state in melanoma.
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Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
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Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
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Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition.
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Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric.
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Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
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TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
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TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology.
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The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer.
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The expression of Claudin-4 in gastric cancer tissue: A single center experience.
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The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma.
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The role of WNT10B in normal prostate gland development and prostate cancer.
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The role of epithelial plasticity in prostate cancer dissemination and treatment resistance.
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Toward understanding cancer stem cell heterogeneity in the tumor microenvironment.
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Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.
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Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.
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mRNA profiling of a well-differentiated G1 pancreatic NET correlates with immunohistochemistry profile: a case report.
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microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu).
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Keywords of People
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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McCall, Shannon Jones,
Associate Professor of Pathology,
Pathology