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Subject Areas on Research
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A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion.
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A licence to kill during inflammation.
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A noncanonical function of cGAMP in inflammasome priming and activation.
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A possible mechanism underlying mood disorders associated with LUTS: Chronic bladder outlet obstruction causes NLRP3-dependent inflammation in the hippocampus and depressive behavior in rats.
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A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.
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Activation of the NLRP3 inflammasome by intracellular poly I:C.
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Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation.
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An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.
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An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.
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Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.
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Application of immobilized ATP to the study of NLRP inflammasomes.
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Autophagy links inflammasomes to atherosclerotic progression.
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Bisphosphonates target B cells to enhance humoral immune responses.
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Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β.
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Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
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Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
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Caspase-1-induced pyroptotic cell death.
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Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome.
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Caspase-11 protects against bacteria that escape the vacuole.
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Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology.
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Detection of cytosolic bacteria by inflammatory caspases.
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Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity.
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Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3.
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Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.
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Down with doublespeak: NAIP/NLRC4 inflammasomes get specific.
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Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.
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Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells.
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Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice.
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Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
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Gasdermins: Effectors of Pyroptosis.
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Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.
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Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
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HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition.
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Holding the Inflammatory System in Check: TLRs and NLRs.
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Human guanylate binding proteins: nanomachines orchestrating host defense.
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Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation.
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IKKα negatively regulates ASC-dependent inflammasome activation.
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IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.
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Immune activation by histones: plusses and minuses in inflammation.
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Immunological Aspects of Age-Related Macular Degeneration.
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Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
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Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
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Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis.
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Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection.
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Inflammasome, Inflammation, and Tissue Homeostasis.
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Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection.
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Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
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Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation.
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Inflammasomes in the urinary tract: a disease-based review.
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Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity.
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Innate Immune Activation in High-risk Donor Kidneys: An Opportunity to Intervene?
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Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection.
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Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
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Investigating the Role of Inflammasome Caspases 1 and 11 in the Acute Radiation Syndrome.
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LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro.
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MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.
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Mechanisms of NOD-like receptor-associated inflammasome activation.
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Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.
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Mitochondrial DNA, oxidants, and innate immunity.
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Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.
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Mitochondrial Quality Control as a Therapeutic Target.
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Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness.
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NAIP inflammasomes give the NOD to bacterial ligands.
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NLRP1 - One NLR to guard them all.
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NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats.
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Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.
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Necroptosis-independent signaling by the RIP kinases in inflammation.
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Necrosis-dependent and independent signaling of the RIP kinases in inflammation.
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Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
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Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins.
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Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
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Olfactory receptors in macrophages and inflammation.
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Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.
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Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection.
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Programmed necrosis in the cross talk of cell death and inflammation.
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Pyroptotic cell death defends against intracellular pathogens.
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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.
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Re-Examination of the Exacerbating Effect of Inflammasome Components during Radiation Injury.
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Reassessing the Evolutionary Importance of Inflammasomes.
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Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.
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Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation.
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Targeting Inflammasomes to Treat Neurological Diseases.
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The AIM2 inflammasome is activated in astrocytes during the late phase of EAE.
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The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.
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The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
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The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction.
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The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.
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The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
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The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.
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The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?
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The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury.
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The role of interferon-β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis - in the perspective of inflammasomes.
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Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
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Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.
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YopM puts caspase-1 on ice.
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[NLRP3 inflammasome and multiple sclerosis/EAE].
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Keywords of People