Inflammasomes
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Subject Areas on Research
- A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion.
- A noncanonical function of cGAMP in inflammasome priming and activation.
- A possible mechanism underlying mood disorders associated with LUTS: Chronic bladder outlet obstruction causes NLRP3-dependent inflammation in the hippocampus and depressive behavior in rats.
- A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.
- Activation of the NLRP3 inflammasome by intracellular poly I:C.
- Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation.
- An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.
- An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.
- Application of immobilized ATP to the study of NLRP inflammasomes.
- Autophagy links inflammasomes to atherosclerotic progression.
- Bisphosphonates target B cells to enhance humoral immune responses.
- Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β.
- Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
- Caspase-1-induced pyroptotic cell death.
- Caspase-11 protects against bacteria that escape the vacuole.
- Control of the innate immune response by the mevalonate pathway.
- Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology.
- Detection of cytosolic bacteria by inflammatory caspases.
- Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.
- Down with doublespeak: NAIP/NLRC4 inflammasomes get specific.
- Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells.
- Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice.
- Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses.
- Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
- Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.
- Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
- HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition.
- Holding the Inflammatory System in Check: TLRs and NLRs.
- Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation.
- IKKα negatively regulates ASC-dependent inflammasome activation.
- IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.
- Immune activation by histones: plusses and minuses in inflammation.
- Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
- Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
- Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis.
- Inflammasome, Inflammation, and Tissue Homeostasis.
- Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection.
- Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
- Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation.
- Inflammasomes in the urinary tract: a disease-based review.
- Innate Immune Activation in High-risk Donor Kidneys: An Opportunity to Intervene?
- Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis.
- Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
- Mechanisms of NOD-like receptor-associated inflammasome activation.
- Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.
- Mitochondrial Quality Control as a Therapeutic Target.
- Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness.
- NAIP inflammasomes give the NOD to bacterial ligands.
- NLRP1 - One NLR to guard them all.
- NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats.
- Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.
- Necroptosis-independent signaling by the RIP kinases in inflammation.
- Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.
- Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection.
- Programmed necrosis in the cross talk of cell death and inflammation.
- Pyroptotic cell death defends against intracellular pathogens.
- Reassessing the Evolutionary Importance of Inflammasomes.
- Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.
- The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.
- The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
- The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction.
- The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.
- The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
- The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.
- The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?
- The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
- The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury.
- The role of interferon-β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis - in the perspective of inflammasomes.
- Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.
- YopM puts caspase-1 on ice.
- [NLRP3 inflammasome and multiple sclerosis/EAE].
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Keywords of People
- Miao, Edward A., Instructor in the Department of Immunology, Immunology
- Shinohara, Mari L., Associate Professor of Immunology, Immunology