Sterol 14-Demethylase

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  Subject Areas on Research

  • Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. 
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.