Diet, High-Fat

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  Subject Areas on Research

  • A classification system for zebrafish adipose tissues. 
  • A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding. 
  • Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease. 
  • Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. 
  • Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes. 
  • Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. 
  • BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis. 
  • Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. 
  • Branched-chain amino acids alter neurobehavioral function in rats. 
  • Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. 
  • Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. 
  • Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure. 
  • Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. 
  • Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. 
  • Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. 
  • Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. 
  • Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. 
  • Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis. 
  • Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. 
  • Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. 
  • Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver. 
  • Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis. 
  • Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction. 
  • Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. 
  • Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. 
  • Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. 
  • Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor. 
  • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. 
  • Extreme elevations of low-density lipoprotein cholesterol with very low carbohydrate, high fat diets. 
  • Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice. 
  • Fetal development of subcutaneous white adipose tissue is dependent on Zfp423. 
  • Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets. 
  • Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis. 
  • GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model. 
  • Gastric bypass surgery restores meal stimulation of the anorexigenic gut hormones glucagon-like peptide-1 and peptide YY independently of caloric restriction. 
  • Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice. 
  • Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance. 
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. 
  • Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity. 
  • High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. 
  • High fat diet induces microbiota-dependent silencing of enteroendocrine cells. 
  • High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet. 
  • High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats. 
  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. 
  • High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. 
  • High-fat diet induces obesity in adult mice but fails to develop pre-penile and penile vascular dysfunction. 
  • High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide. 
  • Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice. 
  • Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice. 
  • Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. 
  • Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia. 
  • Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. 
  • Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy. 
  • Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. 
  • Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice. 
  • Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice. 
  • Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease. 
  • Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity. 
  • Kruppel-like factor 15 is critical for vascular inflammation. 
  • Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. 
  • Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues. 
  • Maternal diet disrupts the placenta-brain axis in a sex-specific manner. 
  • Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet. 
  • Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans. 
  • Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. 
  • Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. 
  • Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. 
  • Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. 
  • Obesity alters the collagen organization and mechanical properties of murine cartilage. 
  • Obesity and altered angiogenic-related gene expression in endometrial cancer. 
  • Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding. 
  • Obesity-Induced Changes in T-Cell Metabolism Are Associated With Impaired Memory T-Cell Response to Influenza and Are Not Reversed With Weight Loss. 
  • Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS. 
  • Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet. 
  • Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. 
  • Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity. 
  • Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. 
  • Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity. 
  • Pharmacological antagonism of the incretin system protects against diet-induced obesity. 
  • Physiological mechanisms of sustained fumagillin-induced weight loss. 
  • Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity. 
  • Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men. 
  • Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding. 
  • Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans. 
  • Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. 
  • Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase. 
  • Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. 
  • Reduced Wheel Running via a High-Fat Diet Is Reversed by a Chow Diet with No Added Benefit from Fecal Microbial Transplants. 
  • Regulation of age-related macular degeneration-like pathology by complement factor H. 
  • Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. 
  • Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. 
  • Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats. 
  • Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction. 
  • SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. 
  • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. 
  • Skeletal muscle mitochondrial fragmentation and impaired bioenergetics from nutrient overload are prevented by carbon monoxide. 
  • Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet. 
  • Sleeve gastrectomy rapidly enhances islet function independently of body weight. 
  • Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model. 
  • Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance. 
  • Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity. 
  • Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. 
  • The Impact of Macronutrients on Retinal Microvasculature among Singapore Pregnant Women during the Mid-Late Gestation. 
  • The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation. 
  • The effects of neuromodulation in a novel obese-prone rat model of detrusor underactivity. 
  • The efficacy of the appetite suppressant, diethylpropion, is dependent on both when it is given (day vs. night) and under conditions of high fat dietary restriction. 
  • The role of the transcription factor ETV5 in insulin exocytosis. 
  • Time-restricted feeding mitigates obesity through adipocyte thermogenesis. 
  • Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis. 
  • Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice. 
  • Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer. 
  • Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele. 
  • Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake. 
  • Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. 
  • β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.