Cell Cycle Checkpoints

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  Subject Areas on Research

  • A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer. 
  • A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest. 
  • A multidisciplinary approach to toxicity management of modern immune checkpoint inhibitors in cancer therapy. 
  • An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. 
  • CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts. 
  • Cell cycle control during early embryogenesis. 
  • Cell division and targeted cell cycle arrest opens and stabilizes basement membrane gaps. 
  • Chemical waves in cell and developmental biology. 
  • DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence. 
  • DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond. 
  • Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest. 
  • Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. 
  • Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays. 
  • Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. 
  • Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. 
  • Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. 
  • Expression level is a key determinant of E2F1-mediated cell fate. 
  • Gaining ground on a cure through synergy: combining checkpoint inhibitors with cancer vaccines. 
  • Identification of cell cycle-regulated, putative hyphal genes in Candida albicans. 
  • Immune Checkpoint Inhibitors for Brain Metastases. 
  • Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer. 
  • Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. 
  • Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells. 
  • Ionizing radiation-induced DNA damage, response, and repair. 
  • Irradiation and immunotherapy: From concept to the clinic. 
  • Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. 
  • Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[18F]Fluoronicotinate Resulting in High Tumor-to-Kidney Ratios. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. 
  • Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques. 
  • PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. 
  • PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA. 
  • Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma. 
  • Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. 
  • Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. 
  • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. 
  • Suberoylanilide hydroxamic acid represses glioma stem-like cells. 
  • Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. 
  • Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair. 
  • TGF-β Family Signaling in the Control of Cell Proliferation and Survival. 
  • Temperature-Induced uncoupling of cell cycle regulators. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle. 
  • The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. 
  • The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells. 
  • The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. 
  • Topology and control of the cell-cycle-regulated transcriptional circuitry. 
  • WRN helicase is a synthetic lethal target in microsatellite unstable cancers.