Gene-Environment Interaction

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  Subject Areas on Research

  • A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience. 
  • A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants. 
  • A gain-of-function polymorphism controlling complex traits and fitness in nature. 
  • A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data. 
  • A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms. 
  • A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. 
  • A mechanism for gene-environment interaction in the etiology of congenital scoliosis. 
  • A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. 
  • A registry of adult African American twins: the Carolina African American Twin Study of Aging. 
  • A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer. 
  • APOE ϵ4, rated life experiences, and affect among centenarians. 
  • Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract. 
  • Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation. 
  • An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. 
  • An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. 
  • Aquatic models, genomics and chemical risk management. 
  • Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors. 
  • Assessment of genetic and nongenetic interactions for the prediction of depressive symptomatology: an analysis of the Wisconsin Longitudinal Study using machine learning algorithms. 
  • Association of Long-term Ambient Black Carbon Exposure and Oxidative Stress Allelic Variants With Intraocular Pressure in Older Men. 
  • Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations. 
  • COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain. 
  • COPD: balancing oxidants and antioxidants. 
  • CRHBP polymorphisms predict chronic pain development following motor vehicle collision. 
  • Can the Environment have a Genetic Basis? A Case Study of Seedling Establishment in Arabidopsis thaliana. 
  • Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. 
  • Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium. 
  • Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. 
  • Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer. 
  • Common human ANK2 variant confers in vivo arrhythmia phenotypes. 
  • Complete effect-profile assessment in association studies with multiple genetic and multiple environmental factors. 
  • Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene. 
  • Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia. 
  • Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. 
  • Demographics, phenotypic health characteristics and genetic analysis of centenarians in China. 
  • Development of aggression. 
  • Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior. 
  • Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. 
  • Does evolutionary theory need a rethink? 
  • Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. 
  • EFFECT OF THE APOE ε4 ALLELE AND COMBAT EXPOSURE ON PTSD AMONG IRAQ/AFGHANISTAN-ERA VETERANS. 
  • Education influences the association between genetic variants and refractive error: a meta-analysis of five Singapore studies. 
  • Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype. 
  • Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders. 
  • Estimating Modifying Effect of Age on Genetic and Environmental Variance Components in Twin Models. 
  • Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression. 
  • Exercise has a disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia/cardiomyopathy in patients without desmosomal mutations. 
  • FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. 
  • Familial influence and childhood trauma in female alcoholism. 
  • Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States. 
  • Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent. 
  • Finding our way through phenotypes. 
  • From the editor: Humans are animals and therefore make saturated fat. 
  • GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. 
  • Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. 
  • Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. 
  • Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications. 
  • Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging. 
  • Gene-environment interaction research in psychiatric epidemiology: a framework and implications for study design. 
  • Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism. 
  • Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. 
  • Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort. 
  • Genes and environment in neonatal intraventricular hemorrhage. 
  • Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. 
  • Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study. 
  • Genetic Moderation of Stress Effects on Corticolimbic Circuitry. 
  • Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. 
  • Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts. 
  • Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status. 
  • Genetics in population health science: strategies and opportunities. 
  • Genetics of exfoliation syndrome and glaucoma. 
  • Genetics of gene expression responses to temperature stress in a sea urchin gene network. 
  • Genetics of nurture: A test of the hypothesis that parents' genetics predict their observed caregiving. 
  • Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. 
  • Genomics in the neonatal nursery: Focus on ROP. 
  • Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions. 
  • Host genotype and age shape the leaf and root microbiomes of a wild perennial plant. 
  • How stable 'should' epigenetic modifications be? Insights from adaptive plasticity and bet hedging. 
  • Human genome-wide measurement of drug-responsive regulatory activity. 
  • IMI - Myopia Genetics Report. 
  • Impact of sample collection participation on the validity of estimated measures of association in the National Birth Defects Prevention Study when assessing gene-environment interactions. 
  • Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. 
  • Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages. 
  • Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms. 
  • Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. 
  • Linking Genes to Cardiovascular Diseases: Gene Action and Gene-Environment Interactions. 
  • Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies. 
  • Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions. 
  • MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors. 
  • Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. 
  • Modeling the influence of genetic and environmental variation on the expression of plant life cycles across landscapes. 
  • Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. 
  • No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision. 
  • Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 
  • Novel likelihood ratio tests for screening gene-gene and gene-environment interactions with unbalanced repeated-measures data. 
  • Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies. 
  • Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts. 
  • Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. 
  • Perinatal risk factors in the development of aggression and violence. 
  • Perspective: Longevity, Stress, Genes and African Americans. 
  • PhenX RISING: real world implementation and sharing of PhenX measures. 
  • Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility. 
  • Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population. 
  • Polyteny: still a giant player in chromosome research. 
  • Reported environmental exposures are inversely associated with obtaining a genetic diagnosis in the Undiagnosed Diseases Network. 
  • Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. 
  • Role of Epstein-Barr virus infection in SLE: gene-environment interactions at the molecular level. 
  • Selection on QTL and complex traits in complex environments. 
  • Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. 
  • Social environment influences the relationship between genotype and gene expression in wild baboons. 
  • Social isolation, loneliness and depression in young adulthood: a behavioural genetic analysis. 
  • Social, behavioral, and genetic linkages from adolescence into adulthood. 
  • Solid tumor second primary neoplasms: who is at risk, what can we do? 
  • Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus. 
  • Temporal control of self-organized pattern formation without morphogen gradients in bacteria. 
  • The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data. 
  • The Alzheimer's Disease Exposome. 
  • The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. 
  • The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium. 
  • The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians. 
  • The evolution of quantitative traits in complex environments. 
  • The quick and the dead: microbial demography at the yeast thermal limit. 
  • The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI. 
  • The role of lipid-related genes, aging-related processes, and environment in healthspan. 
  • The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach. 
  • Transcriptional Regulation in Archaea: From Individual Genes to Global Regulatory Networks. 
  • Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. 
  • Understanding risk for psychopathology through imaging gene-environment interactions. 
  • Unifying genetic canalization, genetic constraint, and genotype-by-environment interaction: QTL by genomic background by environment interaction of flowering time in Boechera stricta. 
  • Using mathematical models to understand metabolism, genes, and disease. 
  • Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene-environment interaction in a 30-day ecological momentary assessment study. 
  • X-Ray Computed Tomography Reveals the Response of Root System Architecture to Soil Texture. 
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  Keywords of People

  • Alberts, Susan C., Robert F. Durden Distinguished Professor of Biology, Duke Science & Society
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology
  • Moorman, Patricia Gripka, Professor in Family Medicine and Community Health, Duke Cancer Institute
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship