Gene-Environment Interaction
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Subject Areas on Research
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A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.
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A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants.
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A gain-of-function polymorphism controlling complex traits and fitness in nature.
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A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.
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A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms.
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A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.
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A mechanism for gene-environment interaction in the etiology of congenital scoliosis.
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A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line.
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A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.
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APOE ϵ4, rated life experiences, and affect among centenarians.
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Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract.
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Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation.
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An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.
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An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans.
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Aquatic models, genomics and chemical risk management.
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Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors.
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Assessment of genetic and nongenetic interactions for the prediction of depressive symptomatology: an analysis of the Wisconsin Longitudinal Study using machine learning algorithms.
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Association of Long-term Ambient Black Carbon Exposure and Oxidative Stress Allelic Variants With Intraocular Pressure in Older Men.
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Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
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COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain.
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COPD: balancing oxidants and antioxidants.
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CRHBP polymorphisms predict chronic pain development following motor vehicle collision.
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Can the Environment have a Genetic Basis? A Case Study of Seedling Establishment in Arabidopsis thaliana.
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Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins.
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Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.
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Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.
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Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.
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Common human ANK2 variant confers in vivo arrhythmia phenotypes.
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Complete effect-profile assessment in association studies with multiple genetic and multiple environmental factors.
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Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.
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Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia.
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Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability.
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Demographics, phenotypic health characteristics and genetic analysis of centenarians in China.
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Development of aggression.
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Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.
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Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.
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Does evolutionary theory need a rethink?
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Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
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EFFECT OF THE APOE ε4 ALLELE AND COMBAT EXPOSURE ON PTSD AMONG IRAQ/AFGHANISTAN-ERA VETERANS.
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Education influences the association between genetic variants and refractive error: a meta-analysis of five Singapore studies.
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Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders.
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Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression.
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Exercise has a disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia/cardiomyopathy in patients without desmosomal mutations.
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FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity.
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Familial influence and childhood trauma in female alcoholism.
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Finding our way through phenotypes.
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From the editor: Humans are animals and therefore make saturated fat.
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GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
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Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.
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Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.
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Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.
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Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging.
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Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism.
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Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report.
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Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.
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Genes and environment in neonatal intraventricular hemorrhage.
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Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.
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Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study.
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Genetic Moderation of Stress Effects on Corticolimbic Circuitry.
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Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.
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Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status.
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Genetics in population health science: strategies and opportunities.
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Genetics of gene expression responses to temperature stress in a sea urchin gene network.
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Genetics of nurture: A test of the hypothesis that parents' genetics predict their observed caregiving.
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Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.
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Genome-wide chromatin state transitions associated with developmental and environmental cues.
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Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
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Genomics in the neonatal nursery: Focus on ROP.
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Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions.
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Host genotype and age shape the leaf and root microbiomes of a wild perennial plant.
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Human genome-wide measurement of drug-responsive regulatory activity.
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IMI - Myopia Genetics Report.
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Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
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Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.
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Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms.
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Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.
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Linking Genes to Cardiovascular Diseases: Gene Action and Gene-Environment Interactions.
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Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies.
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Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions.
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MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors.
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Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.
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Modeling the influence of genetic and environmental variation on the expression of plant life cycles across landscapes.
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Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.
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No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision.
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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
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Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies.
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Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation.
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Perinatal risk factors in the development of aggression and violence.
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PhenX RISING: real world implementation and sharing of PhenX measures.
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Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility.
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Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
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Polyteny: still a giant player in chromosome research.
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Reported environmental exposures are inversely associated with obtaining a genetic diagnosis in the Undiagnosed Diseases Network.
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Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.
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Role of Epstein-Barr virus infection in SLE: gene-environment interactions at the molecular level.
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Selection on QTL and complex traits in complex environments.
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Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results.
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Social environment influences the relationship between genotype and gene expression in wild baboons.
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Social isolation, loneliness and depression in young adulthood: a behavioural genetic analysis.
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Social, behavioral, and genetic linkages from adolescence into adulthood.
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Solid tumor second primary neoplasms: who is at risk, what can we do?
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Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus.
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Temporal control of self-organized pattern formation without morphogen gradients in bacteria.
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The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.
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The Alzheimer's Disease Exposome.
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The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.
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The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians.
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The evolution of quantitative traits in complex environments.
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The evolving metabolic landscape of chromatin biology and epigenetics.
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The quick and the dead: microbial demography at the yeast thermal limit.
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The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI.
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The role of lipid-related genes, aging-related processes, and environment in healthspan.
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The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach.
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Transcriptional Regulation in Archaea: From Individual Genes to Global Regulatory Networks.
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Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis.
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Understanding risk for psychopathology through imaging gene-environment interactions.
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Unifying genetic canalization, genetic constraint, and genotype-by-environment interaction: QTL by genomic background by environment interaction of flowering time in Boechera stricta.
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Using mathematical models to understand metabolism, genes, and disease.
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X-Ray Computed Tomography Reveals the Response of Root System Architecture to Soil Texture.
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Keywords of People
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Alberts, Susan C.,
Robert F. Durden Distinguished Professor of Biology,
Duke Science & Society
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Liu, Yutao,
Adjunct Assistant Professor in the Department of Medicine,
Medicine, Medical Genetics
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Mitchell-Olds, Thomas,
Newman Ivey White Distinguished Professor of Biology,
Biology
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Moorman, Patricia Gripka,
Professor in Family Medicine and Community Health,
Duke Cancer Institute
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Wray, Gregory Allan,
Professor of Biology,
Duke Innovation & Entrepreneurship