Proteolysis

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  Subject Areas on Research

  • A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production. 
  • A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. 
  • A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest. 
  • A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation. 
  • A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes. 
  • ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins. 
  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17. 
  • Androgen receptor variant-driven prostate cancer II: advances in laboratory investigations. 
  • Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling. 
  • Autophagic dysregulation in glaucomatous trabecular meshwork cells. 
  • BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation. 
  • Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. 
  • Bet v 1 and other birch allergens are more resistant to proteolysis and more abundant than other birch pollen proteins. 
  • CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease. 
  • Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. 
  • Chemically induced proximity in biology and medicine. 
  • Chemo-Selection Strategy for Limited Proteolysis Experiments on the Proteomic Scale. 
  • Comparative Analysis of Mass-Spectrometry-Based Proteomic Methods for Protein Target Discovery Using a One-Pot Approach. 
  • Convergent evolution of escape from hepaciviral antagonism in primates. 
  • D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction. 
  • DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. 
  • Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media. 
  • Discovery and fine mapping of serum protein loci through transethnic meta-analysis. 
  • Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. 
  • Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. 
  • Endoglin interacts with VEGFR2 to promote angiogenesis. 
  • Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling. 
  • F-actin homeostasis through transcriptional regulation and proteasome-mediated proteolysis. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Functional selection of protease inhibitory antibodies. 
  • GPCR desensitization: Acute and prolonged phases. 
  • Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4. 
  • HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING. 
  • Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. 
  • Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer. 
  • Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice. 
  • Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. 
  • Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF. 
  • Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. 
  • Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics. 
  • K63 polyubiquitination is a new modulator of the oxidative stress response. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis. 
  • Mechanism of Dual Targeting of the Phytochrome Signaling Component HEMERA/pTAC12 to Plastids and the Nucleus. 
  • Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors. 
  • MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury. 
  • Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition. 
  • Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. 
  • Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. 
  • Mutant p53 as an Antigen in Cancer Immunotherapy. 
  • Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains. 
  • New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease. 
  • Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock. 
  • Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. 
  • Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation. 
  • Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. 
  • Pathogen Evasion of Chemokine Response Through Suppression of CXCL10. 
  • Pathologic Proteolytic Processing of N-Cadherin as a Marker of Human Fibrotic Disease. 
  • Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. 
  • Phosphorylation at tyrosine 262 promotes GADD34 protein turnover. 
  • Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade 
  • Polysomnographic findings in infantile Pompe disease. 
  • Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses. 
  • Premature translational termination products are rapidly degraded substrates for MHC class I presentation. 
  • Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. 
  • Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart. 
  • Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer. 
  • Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches. 
  • Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. 
  • Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. 
  • Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. 
  • Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins. 
  • Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme. 
  • SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis. 
  • SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. 
  • Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization. 
  • Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. 
  • Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. 
  • Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. 
  • Structural Aspects of Auxin Signaling. 
  • Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. 
  • Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway. 
  • The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. 
  • The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. 
  • The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. 
  • The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. 
  • The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells. 
  • The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. 
  • The crosstalk between autophagy and apoptosis: where does this lead? 
  • The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding. 
  • The inoculum effect and band-pass bacterial response to periodic antibiotic treatment. 
  • The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades. 
  • The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. 
  • Translating antibody-binding peptides into peptoid ligands with improved affinity and stability. 
  • Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. 
  • Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. 
  • Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). 
  • Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. 
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  Keywords of People

  • Abbruzzese, James, D. C. I. Distinguished Professor of Medical Oncology, Medicine, Medical Oncology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Meyer, Joel, Associate Professor of Environmental Genomics in the Division of Environmental Sciences and Policy, Nicholas Institute-Energy Initiative