Endoplasmic Reticulum Stress

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  Subject Areas on Research

  • A H(a)rd Way to Adapt in Cardiac Hypertrophy. 
  • Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes. 
  • Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability. 
  • Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression. 
  • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. 
  • Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. 
  • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 
  • DYT-TOR1A subcellular proteomics reveals selective vulnerability of the nuclear proteome to cell stress. 
  • Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas. 
  • Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival. 
  • Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. 
  • Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. 
  • ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. 
  • ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. 
  • Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. 
  • Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. 
  • Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders. 
  • Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • High fat diet induces microbiota-dependent silencing of enteroendocrine cells. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. 
  • IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. 
  • Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. 
  • Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity. 
  • KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. 
  • MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa. 
  • Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis. 
  • PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis. 
  • Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. 
  • Phosphorylation at tyrosine 262 promotes GADD34 protein turnover. 
  • Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in human hepatocytes. 
  • Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. 
  • Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells. 
  • Salicylic acid-independent role of NPR1 is required for protection from proteotoxic stress in the plant endoplasmic reticulum. 
  • Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes. 
  • Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. 
  • Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease. 
  • The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. 
  • The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. 
  • The regulation of ferroptosis by MESH1 through the activation of the integrative stress response. 
  • The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure. 
  • The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. 
  • Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. 
  • Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. 
  • Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. 
  • Unfolded protein response in brain ischemia: A timely update.