Endoplasmic Reticulum Stress

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  Subject Areas on Research

  • A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. 
  • Bmp Induces Osteoblast Differentiation through both Smad4 and mTORC1 Signaling. 
  • Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression. 
  • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. 
  • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 
  • Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. 
  • Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas. 
  • Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival. 
  • Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. 
  • Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence. 
  • Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. 
  • Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. 
  • Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis. 
  • Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells. 
  • Phosphorylation at tyrosine 262 promotes GADD34 protein turnover. 
  • Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. 
  • Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease. 
  • The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. 
  • The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. 
  • The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. 
  • Unfolded protein response in brain ischemia: A timely update.