Thymocytes

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  Subject Areas on Research

  • Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice. 
  • Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Editorial: TRPV1: how thymocytes sense stress and respond with autophagy. 
  • Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation. 
  • IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection. 
  • Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. 
  • Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. 
  • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. 
  • Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters. 
  • T-cell receptor α enhancer is inactivated in αβ T lymphocytes. 
  • Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire. 
  • The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. 
  • The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis. 
  • The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development. 
  • The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells. 
  • Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. 
  • αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. 
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  Keywords of People

  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology