Thymocytes

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  Subject Areas on Research

  • Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice. 
  • Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex. 
  • Editorial: TRPV1: how thymocytes sense stress and respond with autophagy. 
  • Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes. 
  • Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation. 
  • IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. 
  • Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. 
  • Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. 
  • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. 
  • Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. 
  • Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters. 
  • T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution. 
  • T-cell receptor α enhancer is inactivated in αβ T lymphocytes. 
  • TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. 
  • Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire. 
  • The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. 
  • The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis. 
  • The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development. 
  • The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells. 
  • Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development. 
  • Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development. 
  • Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire. 
  • Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. 
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  Keywords of People

  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology