Thymocytes
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Subject Areas on Research
- Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.
- Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.
- An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
- Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells.
- Differential requirement of RasGRP1 for γδ T cell development and activation.
- E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
- Editorial: TRPV1: how thymocytes sense stress and respond with autophagy.
- Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes.
- Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.
- IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus.
- Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells.
- Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
- Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.
- Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.
- Mitochondrial dysfunction in ataxia-telangiectasia.
- ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.
- Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
- Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.
- T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.
- T-cell receptor α enhancer is inactivated in αβ T lymphocytes.
- TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
- Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.
- The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
- The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
- The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.
- The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells.
- Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
- Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development.
- Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire.
- Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53.
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Keywords of People
- Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
- Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology