Morpholinos
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Subject Areas on Research
- AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos.
- Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers.
- Delivery of phosphorodiamidate morpholino antisense oligomers in cancer cells.
- Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.
- Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer.
- Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans.
- Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos.
- Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo.
- In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.
- In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors.
- In vivo modeling of the morbid human genome using Danio rerio.
- Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.
- Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia.
- Myo1c is an unconventional myosin required for zebrafish glomerular development.
- Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.
- Perturbations to the hedgehog pathway in sea urchin embryos.
- Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model.
- X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells.
- Zebrafish assays of ciliopathies.
- c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.