Morpholinos

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  Subject Areas on Research

  • AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos. 
  • Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Delivery of phosphorodiamidate morpholino antisense oligomers in cancer cells. 
  • Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function. 
  • Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino. 
  • Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. 
  • Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. 
  • Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos. 
  • Guanine analogues enhance antisense oligonucleotide-induced exon skipping in dystrophin gene in vitro and in vivo. 
  • Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo. 
  • Identification of nonvisual photomotor response cells in the vertebrate hindbrain. 
  • In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. 
  • In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors. 
  • In vivo modeling of the morbid human genome using Danio rerio. 
  • Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. 
  • Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. 
  • Myo1c is an unconventional myosin required for zebrafish glomerular development. 
  • Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. 
  • Perturbations to the hedgehog pathway in sea urchin embryos. 
  • Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model. 
  • SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. 
  • Targeted skipping of human dystrophin exons in transgenic mouse model systemically for antisense drug development. 
  • X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. 
  • Zebrafish assays of ciliopathies. 
  • c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.