Wnt Signaling Pathway

• 

  Subject Areas on Research

  • A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion. 
  • A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth. 
  • A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models. 
  • A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. 
  • Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling. 
  • Adult human nasal mesenchymal-like stem cells restore cochlear spiral ganglion neurons after experimental lesion. 
  • Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. 
  • An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. 
  • An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. 
  • An embryonic system to assess direct and indirect Wnt transcriptional targets. 
  • An itch for things remote: The journey of Wnts. 
  • Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis. 
  • BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. 
  • Broad regulation of gene isoform expression by Wnt signaling in cancer. 
  • Burden of rare deleterious variants in WNT signaling genes among 511 myelomeningocele patients. 
  • CBX2 is required to stabilize the testis pathway by repressing Wnt signaling. 
  • CCN1 Regulates Chondrocyte Maturation and Cartilage Development. 
  • CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping. 
  • Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy. 
  • Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors. 
  • Conserved action of β-catenin during female fate determination in the red-eared slider turtle. 
  • Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling. 
  • Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. 
  • Discovery and Optimization of a Porcupine Inhibitor. 
  • ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma. 
  • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 
  • FXR Regulates Intestinal Cancer Stem Cell Proliferation. 
  • FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. 
  • Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. 
  • Functional regulation of Wnt protein through post-translational modifications. 
  • Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. 
  • Glypican-4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling. 
  • Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. 
  • Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing. 
  • High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. 
  • Human myelomeningocele risk and ultra-rare deleterious variants in genes associated with cilium, WNT-signaling, ECM, cytoskeleton and cell migration. 
  • IAP proteins: regulators of cell migration and development. 
  • Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. 
  • Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype. 
  • Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. 
  • Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition. 
  • Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition. 
  • Insulin/IGF-dependent Wnt signaling promotes formation of germline tumors and other developmental abnormalities following early-life starvation in Caenorhabditis elegans. 
  • KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway. 
  • LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. 
  • LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. 
  • Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. 
  • Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration. 
  • Moving upstream in the war on WNTs. 
  • N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN. 
  • NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. 
  • Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth. 
  • Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy. 
  • Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. 
  • Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. 
  • Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling. 
  • Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis. 
  • Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. 
  • Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. 
  • Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. 
  • Platelets promote pulmonary pull of polys. 
  • Precise regulation of porcupine activity is required for physiological Wnt signaling. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. 
  • Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. 
  • Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors. 
  • Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. 
  • Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm. 
  • Small molecule modulators of Wnt/β-catenin signaling. 
  • Stemming Lung Disease? 
  • Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/β-Catenin Signaling. 
  • Stromal control of intestinal development and the stem cell niche. 
  • Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling. 
  • Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure. 
  • Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs. 
  • Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis. 
  • The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition. 
  • The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms. 
  • The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets. 
  • The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. 
  • The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. 
  • The role of Sfrp and DKK proteins in cardiomyocyte development. 
  • USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. 
  • Unwinding the Wnt action of casein kinase 1. 
  • Updating the Wnt pathways. 
  • Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. 
  • WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. 
  • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. 
  • WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. 
  • WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis. 
  • Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis. 
  • Wnt Signaling and Drug Resistance in Cancer. 
  • Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1. 
  • Wnt addiction of genetically defined cancers reversed by PORCN inhibition. 
  • Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging. 
  • Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells. 
  • Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation. 
  • Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. 
  • Wnts and the hallmarks of cancer. 
  • Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. 
  • Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects. 
  • X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells. 
  • YJ5 as an immunohistochemical marker of osteogenic lineage. 
  • β-Arrestin2 mediates the initiation and progression of myeloid leukemia. 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology