Subject Areas on Research
- A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.
- Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem.
- CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.
- Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.
- Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.
- Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
- Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.
- LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
- Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal.
- Testis development requires the repression of Wnt4 by Fgf signaling.
- WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation.
- WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.