Cognitive Dysfunction

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  Subject Areas on Research

  • 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. 
  • A Geriatrics Perspective on Dementia Prevention and Treatment. 
  • A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration. 
  • A Subgroup Analysis of the Impact of Vortioxetine on Functional Capacity, as Measured by UPSA, in Patients with Major Depressive Disorder and Subjective Cognitive Dysfunction. 
  • A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data. 
  • Alterations in metabolic pathways and networks in Alzheimer's disease. 
  • Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. 
  • American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: Sensory Impairment and Cognitive Decline in Older Adults. 
  • Amnestic mild cognitive impairment and incident dementia and Alzheimer's disease in geriatric depression. 
  • Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity. 
  • Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study. 
  • An assessment by the Statin Cognitive Safety Task Force: 2014 update. 
  • Antiretroviral treatment initiation does not differentially alter neurocognitive functioning over time in youth with behaviorally acquired HIV. 
  • Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. 
  • Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease. 
  • Assessment of Dentally Related Function in Individuals with Cognitive Impairment: The Dental Activities Test. 
  • Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT). 
  • Association Between Neurocognitive Decline and Visual Field Variability in Glaucoma. 
  • Association between baseline cognitive impairment and postoperative delirium in elderly patients undergoing surgery for adult spinal deformity. 
  • Association between patient-reported hearing and visual impairments and functional, psychological, and cognitive status among older adults with cancer. 
  • Association between tooth loss and cognitive decline: A 13-year longitudinal study of Chinese older adults. 
  • Association between tooth loss and cognitive function among 3063 Chinese older adults: a community-based study. 
  • Association of CSF CD40 levels and synaptic degeneration across the Alzheimer's disease spectrum. 
  • Association of Nondisease-Specific Problems with Mortality, Long-Term Care, and Functional Impairment among Older Adults Who Require Skilled Nursing Care after Dialysis Initiation. 
  • Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease. 
  • Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly. 
  • Association of silent lacunar infarct with brain atrophy and cognitive impairment. 
  • Atomic connectomics signatures for characterization and differentiation of mild cognitive impairment. 
  • Beyond Thiamine: Treatment for Cognitive Impairment in Korsakoff's Syndrome. 
  • Body mass and cognitive decline are indirectly associated via inflammation among aging adults. 
  • Brain atrophy rates in first degree relatives at risk for Alzheimer's. 
  • Bridging silos: Taking a page from the Alzheimer playbook. 
  • Building research in diet and cognition: The BRIDGE randomized controlled trial. 
  • CAP--advancing the evaluation of preclinical Alzheimer disease treatments. 
  • CSF biomarker changes precede symptom onset of mild cognitive impairment. 
  • Can Addressing Personality Change Enhance Cognitive Functioning and Delay Development of Mild Cognitive Impairment? 
  • Cardiovascular disease and cognitive decline in postmenopausal women: results from the Women's Health Initiative Memory Study. 
  • Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia. 
  • Caregivers in China: knowledge of mild cognitive impairment. 
  • Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features. 
  • Challenges in measuring the effects of pharmacological interventions on cognitive and adaptive functioning in individuals with Down syndrome: A systematic review. 
  • Change of Cognitive Function in U.S. Chinese Older Adults: A Population-Based Study. 
  • Characteristics of neurocognitive functions in mild cognitive impairment with depression. 
  • Characterization of bilateral frontal lobe cerebral oxygen saturation in patients with mild traumatic brain injury. 
  • Chemotherapy-related cognitive impairment in older patients with cancer. 
  • Classifying neurocognitive disorders: the DSM-5 approach. 
  • Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder. 
  • Clinical outcomes of older depressed patients with and without comorbid neuroticism. 
  • Cognitive Decline and Disrupted Cognitive Trajectory in Schizophrenia. 
  • Cognitive Effects of MIN-101 in Patients With Schizophrenia and Negative Symptoms: Results From a Randomized Controlled Trial. 
  • Cognitive Function and Changes in Cognitive Function as Predictors of Incident Cardiovascular Disease: The Women's Health Initiative Memory Study. 
  • Cognitive Function: Is There More to Anticoagulation in Atrial Fibrillation Than Stroke? 
  • Cognitive performance in antidepressant-free recurrent major depressive disorder. 
  • Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue. 
  • Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in detecting multi-domain mild cognitive impairment in a Chinese sub-sample drawn from a population-based study. 
  • Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer's Disease. 
  • Connectome-scale assessments of structural and functional connectivity in MCI. 
  • Constrained sparse functional connectivity networks for MCI classification. 
  • Cortical auditory evoked responses of older adults with and without probable mild cognitive impairment. 
  • Cross-cultural adaptation and psychometric properties of the MMSE and MoCA questionnaires in Tanzanian Swahili for a traumatic brain injury population. 
  • Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. 
  • Depressive symptoms and mild cognitive impairment in the elderly: an ominous combination. 
  • Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease. 
  • Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial. 
  • Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. 
  • Editorial Comment: Is It Time to Take the "Sub" Out of Subsyndromal Depression? 
  • Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort. 
  • Effectiveness of Florbetapir PET Imaging in Changing Patient Management. 
  • Effectiveness of a Personalized Brain-Computer Interface System for Cognitive Training in Healthy Elderly: A Randomized Controlled Trial. 
  • Effects of early life stress on depression, cognitive performance and brain morphology. 
  • Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study. 
  • Evaluation and Management of Autoimmune Encephalitis: A Clinical Overview for the Practicing Child Psychiatrist. 
  • Event-related functional magnetic resonance imaging changes during relational retrieval in normal aging and amnestic mild cognitive impairment. 
  • Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct. 
  • Fine-granularity functional interaction signatures for characterization of brain conditions. 
  • Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging. 
  • Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study. 
  • Functional decline in older adults. 
  • Functional limitations in older adults who have cognitive impairment without dementia. 
  • Functional signature of conversion of patients with mild cognitive impairment. 
  • Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study. 
  • General anesthetic and the risk of dementia in elderly patients: current insights. 
  • Generation and quality control of lipidomics data for the alzheimer's disease neuroimaging initiative cohort. 
  • Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans. 
  • Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study. 
  • Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification. 
  • Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study. 
  • Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study. 
  • Hearing Loss: The Silent Risk for Psychiatric Disorders in Late Life. 
  • Identification of MCI individuals using structural and functional connectivity networks. 
  • Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease. 
  • Identification of mild cognitive impairment in ACTIVE: algorithmic classification and stability. 
  • Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making. 
  • Impaired Context Processing is Attributable to Global Neuropsychological Impairment in Schizophrenia and Psychotic Bipolar Disorder. 
  • Independent Association Between Preoperative Cognitive Status and Discharge Location After Surgery: A Strategy to Reduce Resource Use After Surgery for Deformity. 
  • Innovation in care for individuals with cognitive impairment: Can reimbursement policy spread best practices? 
  • Interview-based assessment of cognition is a strong predictor of quality of life in patients with schizophrenia and severe negative symptoms. 
  • Intraindividual variability in psychometrically defined mild cognitive impairment status in older African Americans. 
  • Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere. 
  • Latent Profile Analysis and Conversion to Psychosis: Characterizing Subgroups to Enhance Risk Prediction. 
  • Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health. 
  • Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment. 
  • Long-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study. 
  • Long-Term Cognitive Decline After Newly Diagnosed Heart Failure: Longitudinal Analysis in the CHS (Cardiovascular Health Study). 
  • Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats. 
  • Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. 
  • Longitudinal Cognitive Changes in Young Individuals at Ultrahigh Risk for Psychosis. 
  • Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression. 
  • Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients. 
  • Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease. 
  • Lowering the Floor on Trail Making Test Part B: Psychometric Evidence for a New Scoring Metric. 
  • Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth. 
  • Memory Impairment in HIV-Infected Individuals with Early and Late Initiation of Regular Marijuana Use. 
  • Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort. 
  • Metabolic network failures in Alzheimer's disease: A biochemical road map. 
  • Metabolic syndrome and amnestic mild cognitive impairment: Singapore Longitudinal Ageing Study-2 findings. 
  • Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder. 
  • Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes. 
  • Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice. 
  • Montreal Cognitive Assessment for screening mild cognitive impairment: variations in test performance and scores by education in Singapore. 
  • Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images. 
  • Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease. 
  • Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter? 
  • Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms. 
  • Neurocognitive disorders in DSM-5. 
  • Neurodevelopmental Impairment Among Extremely Preterm Infants in the Neonatal Research Network. 
  • Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease. 
  • Neuropsychological decline in schizophrenia from the premorbid to the postonset period: evidence from a population-representative longitudinal study. 
  • Neuroticism Traits Selectively Impact Long Term Illness Course and Cognitive Decline in Late-Life Depression. 
  • Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. 
  • New applications of disease genetics and pharmacogenetics to drug development. 
  • Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial. 
  • Nurses' concerns about caring for patients with acute and chronic traumatic brain injury. 
  • Occupational Attainment as Risk Factor for Progression from Mild Cognitive Impairment to Alzheimer's Disease: A CREDOS Study. 
  • Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. 
  • Patient Factors Associated with Extended Length of Stay in the Psychiatric Inpatient Units of a Large Urban County Hospital. 
  • Person-Centered Incontinence Care in Residential Care Facilities for Older Adults With Cognitive Decline: Feasibility and Preliminary Effects on Quality of Life and Quality of Care. 
  • Pharmacological interventions to improve cognition and adaptive functioning in Down syndrome: Strides to date. 
  • Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease. 
  • Physical Frailty, Cognitive Impairment, and the Risk of Neurocognitive Disorder in the Singapore Longitudinal Ageing Studies. 
  • Physical exercise increases involvement of motor networks as a compensatory mechanism during a cognitively challenging task. 
  • Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. 
  • Postoperative Delirium and Postoperative Cognitive Dysfunction: Two Sides of the Same Coin? 
  • Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach. 
  • Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data. 
  • Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter? 
  • Predictive models of resting state networks for assessment of altered functional connectivity in mild cognitive impairment. 
  • Predictors of Ventriculoperitoneal Shunt Revision in Patients with Idiopathic Normal Pressure Hydrocephalus. 
  • Prefrontal contributions to relational encoding in amnestic mild cognitive impairment. 
  • Preoperative Cognitive Impairment As a Predictor of Postoperative Outcomes in a Collaborative Care Model. 
  • Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives. 
  • Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study. 
  • Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. 
  • Prevalence of neuropsychiatric symptoms in CIND and its subtypes: the Cache County Study. 
  • Protocol for a feasibility randomised controlled trial of Screening and Enhanced Risk management for Vascular Event-related Decline in Memory (SERVED Memory). 
  • Psychosocial Risk and Protective Factors and Incident Mild Cognitive Impairment and Dementia in Community Dwelling Elderly: Findings from the Singapore Longitudinal Ageing Study. 
  • Racial/Ethnic Differences in Cognitive Symptoms During the Menopausal Transition. 
  • Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. 
  • Recommended patient-reported core set of symptoms to measure in adult cancer treatment trials. 
  • Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression. 
  • Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease. 
  • Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease. 
  • Response to Bora. 
  • Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings. 
  • Resting-state multi-spectrum functional connectivity networks for identification of MCI patients. 
  • Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease. 
  • Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease. 
  • Schizophrenia, narrative, and neurocognition: The utility of life-stories in understanding social problem-solving skills. 
  • Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment. 
  • Self-Reported Cognitive Impairment Across Racial/Ethnic Groups in the United States, National Health Interview Survey, 1997-2015. 
  • Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease. 
  • Serum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment. 
  • Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease. 
  • Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes. 
  • Short-Term Changes in the Prevalence of Probable Dementia: An Analysis of the 2011-2015 National Health and Aging Trends Study. 
  • Sleep, Cognitive impairment, and Alzheimer's disease: A Systematic Review and Meta-Analysis. 
  • Social Support, Social Strain, and Cognitive Function Among Community-Dwelling U.S. Chinese Older Adults. 
  • Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. 
  • Stability and Change in Cognitive Status Classification of Black Older Adults. 
  • Subjective cognitive impairment and quality of life: a systematic review. 
  • Subthreshold Psychosis in 22q11.2 Deletion Syndrome: Multisite Naturalistic Study. 
  • TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype. 
  • Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. 
  • Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults. 
  • Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: a systematic review. 
  • The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. 
  • The Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI. 
  • The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease. 
  • The Association Between Toxic Exposures and Chronic Multisymptom Illness in Veterans of the Wars of Iraq and Afghanistan. 
  • The Devil Is in the Details: Comparison of Postoperative Delirium and Neurocognitive Dysfunction. 
  • The Impact of Marijuana Use on Memory in HIV-Infected Patients: A Comprehensive Review of the HIV and Marijuana Literatures. 
  • The Impact of Medication Anticholinergic Burden on Cognitive Performance in People With Schizophrenia. 
  • The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians. 
  • The Role of Cognition and Social Functioning as Predictors in the Transition to Psychosis for Youth With Attenuated Psychotic Symptoms. 
  • The Vascular Impairment of Cognition Classification Consensus Study. 
  • The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study. 
  • The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study. 
  • The association between cognitive function and subsequent depression: a systematic review and meta-analysis. 
  • The immune response of the human brain to abdominal surgery. 
  • The impact of residential status on cognitive decline among older adults in China: Results from a longitudinal study. 
  • The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment. 
  • The relationship between negative symptom subdomains and cognition. 
  • The relationship between obesity and cognitive health and decline. 
  • Time Trends in the Prevalence of Neurocognitive Disorders and Cognitive Impairment in the United States: The Effects of Disease Severity and Improved Ascertainment. 
  • Treating cognitive impairment in depression: an unmet need. 
  • Type 2 diabetes mellitus, brain atrophy, and cognitive decline. 
  • U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults. 
  • Urban-rural differences in the association between access to healthcare and health outcomes among older adults in China. 
  • Using high-dimensional machine learning methods to estimate an anatomical risk factor for Alzheimer's disease across imaging databases. 
  • Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. 
  • Utility of a brief computerized battery to assess HIV-associated neurocognitive impairment in a resource-limited setting. 
  • Utilizing Trigger Films to Enhance Communication Skills of Home Care Clinicians. 
  • Validation of the Persian version of the Schizophrenia Cognition Rating Scale (SCoRS) in patients with schizophrenia. 
  • Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). 
  • Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline. 
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  Keywords of People

  • Doraiswamy, P. Murali, Professor of Psychiatry and Behavioral Sciences, Duke Science & Society