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Subject Areas on Research
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A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
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ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.
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Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.
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Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.
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Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.
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Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming.
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Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.
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Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx.
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Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.
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CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression.
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Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye.
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Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs.
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Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity.
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Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro.
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Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
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Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
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Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.
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Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen.
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Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers.
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Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.
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Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes.
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Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.
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Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.
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Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose.
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Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor.
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Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.
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Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.
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Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.
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Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.
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Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells.
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Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
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HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.
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Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
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IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells.
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In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia.
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In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP).
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In vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells.
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Increased BCR responsiveness in B cells from patients with chronic GVHD.
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Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
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Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
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Interferon lambda protects the female reproductive tract against Zika virus infection.
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Isolation and Culture of Murine Primary Chondrocytes: Costal and Growth Plate Cartilage.
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Isolation and culture of murine primary chondrocytes.
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KIF18B is a cell type-specific regulator of spindle orientation in the epidermis.
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Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells.
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Lowering circulating apolipoprotein E levels improves aged bone fracture healing.
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M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.
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MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.
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MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.
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Macrophage and adipocyte interaction as a source of inflammation in kidney disease.
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Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes.
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Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells.
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Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
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Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.
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Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification.
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Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes.
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Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.
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Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
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Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.
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PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.
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PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.
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Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
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Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells.
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Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells.
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Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl.
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RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
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Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.
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Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells.
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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.
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Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release.
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Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.
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Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes.
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Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.
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Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
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The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
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The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.
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The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target.
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The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression.
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The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies.
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The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.
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The transcription factor Twist1 in the distal nephron but not in macrophages propagates aristolochic acid nephropathy.
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The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
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Tracing Self-Reactive B Cells in Normal Mice.
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Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format.
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Tropism of SARS-CoV-2 for human cortical astrocytes.
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WIPI1 is a conserved mediator of right ventricular failure.
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Wild-type Kras expands and exhausts hematopoietic stem cells.
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cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis.
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ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress.
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β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.
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Keywords of People