Optical Imaging

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  Subject Areas on Research

  • A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. 
  • A Highly Effective and Ultra-Long-Acting Anti-Glaucoma Drug, with a Novel Periorbital Delivery Method. 
  • A One-Step Staining Protocol for In-Gel Fluorescent Visualization of Proteins. 
  • A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. 
  • A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. 
  • A comparison of cup-to-disc ratio estimates by fundus biomicroscopy and stereoscopic optic disc photography in the Tema Eye Survey. 
  • A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings. 
  • A striatal interneuron circuit for continuous target pursuit. 
  • Accuracy of Diagnostic Imaging Modalities for Classifying Pediatric Eyes as Papilledema Versus Pseudopapilledema. 
  • Advancing optical imaging for breast margin assessment: an analysis of excisional time, cautery, and patent blue dye on underlying sources of contrast. 
  • An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. 
  • An intravital window to image the colon in real time. 
  • Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium. 
  • Anterior segment photography in pediatric eyes using the Lytro light field handheld noncontact camera. 
  • Blue Light Fundus Autofluorescence in Coats Disease. 
  • Body Composition Measurements from Birth through 5 Years: Challenges, Gaps, and Existing & Emerging Technologies-A National Institutes of Health workshop. 
  • Can the localization of primary colonic tumors be improved by staging CT without specific bowel preparation compared to optical colonoscopy? 
  • Characterization of the Spectrum of Ophthalmic Changes in Patients With Alagille Syndrome. 
  • Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. 
  • Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum. 
  • Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit. 
  • Deep-tissue SWIR imaging using rationally designed small red-shifted near-infrared fluorescent protein. 
  • Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer. 
  • Detailed analysis of polymer response to delivery balloon expansion of drug-eluting stents versus bare metal stents. 
  • Detection of autofluorescent Mycobacterium chelonae in living zebrafish. 
  • Detection of sentinel nodes for endometrial cancer with robotic assisted fluorescence imaging: cervical versus hysteroscopic injection. 
  • Determining the False-Negative Rate Using Fluorescence Image-Assisted Sentinel Lymph Node Biopsy in Cutaneous Melanoma. 
  • Diagnosing Liver Fibrosis and Cirrhosis: Serum, Imaging, or Tissue? 
  • Direct Optical Imaging of Graphene In Vitro by Nonlinear Femtosecond Laser Spectral Reshaping 
  • Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model. 
  • Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. 
  • Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. 
  • Factors for Differential Outcome Across Cancers in Clinical Molecule-Targeted Fluorescence Imaging. 
  • First-in-human intraoperative near-infrared fluorescence imaging of glioblastoma using cetuximab-IRDye800. 
  • Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy 
  • Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis. 
  • Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. 
  • High-throughput optical imaging and spectroscopy of individual carbon nanotubes in devices. 
  • Highly photostable fluorescent labeling of proteins in live cells using exchangeable coiled coils heterodimerization. 
  • ICG angiography predicts burn scarring within 48 h of injury in a porcine vertical progression burn model. 
  • Imaging Biomaterial-Tissue Interactions. 
  • Imaging Dynamics Beneath Turbid Media via Parallelized Single-Photon Detection. 
  • Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings. 
  • Imaging deformation of adherent cells due to shear stress using quantitative phase imaging. 
  • Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells. 
  • In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone. 
  • Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy Improves the Accuracy of Sentinel Lymph Node Biopsy in Melanoma. 
  • Indocyanine green fluorescence imaging with lymphoscintigraphy for sentinel node biopsy in head and neck melanoma. 
  • Indocyanine green-loaded nanoparticles for image-guided tumor surgery. 
  • Information-Theoretic Approach and Fundamental Limits of Resolving Two Closely Timed Neuronal Spikes in Mouse Brain Calcium Imaging. 
  • Innovations in Intraoperative Tumor Visualization. 
  • International Image Concordance Study to Compare a Point-of-Care Tampon Colposcope With a Standard-of-Care Colposcope. 
  • Intravital optical imaging for immune cell tracking after photoimmunotherapy with plasmonic gold nanostars. 
  • Laser-assisted indocyanine green dye angiography accurately predicts the split-thickness graft timing of integra artificial dermis. 
  • Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens. 
  • Light for Life: International Year of Light 2015. 
  • Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion. 
  • Low-cost measurement of face mask efficacy for filtering expelled droplets during speech. 
  • Mapping solvation heterogeneity in live cells by hyperspectral stimulated Raman scattering microscopy. 
  • Measuring dilution of microbicide gels with optical imaging. 
  • Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging. 
  • Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues. 
  • Mouse Higher Visual Areas Provide Both Distributed and Specialized Contributions to Visually Guided Behaviors. 
  • Multimodal imaging and genetic findings in a case of ARSG-related atypical Usher syndrome. 
  • Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators. 
  • Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study). 
  • Near-Infrared Reflectance Imaging for Quantification of Atrophy Associated with Age-Related Macular Degeneration. 
  • Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. 
  • Noninvasive optical spectroscopy for identification of non-melanoma skin cancer: Pilot study. 
  • Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex. 
  • Optical High Content Nanoscopy of Epigenetic Marks Decodes Phenotypic Divergence in Stem Cells. 
  • Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins. 
  • Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues. 
  • Pathway-Specific Striatal Substrates for Habitual Behavior. 
  • Peripapillary choroidal thickness in young Asians with high myopia. 
  • Peripheral Retinal Changes Associated with Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group. 
  • Probabilistic fluorescence-based synapse detection. 
  • Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH. 
  • Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration. 
  • Single-Step Assembly of Multimodal Imaging Nanocarriers: MRI and Long-Wavelength Fluorescence Imaging. 
  • Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report. 
  • Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. 
  • Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy. 
  • Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer. 
  • Targeting Fluorescent Nanodiamonds to Vascular Endothelial Growth Factor Receptors in Tumor. 
  • Temporal modulation of collective cell behavior controls vascular network topology. 
  • The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice. 
  • Tissue clearing techniques for three-dimensional optical imaging of intact human prostate and correlations with multi-parametric MRI. 
  • Tracking and quantification of single-walled carbon nanotubes in fish using near infrared fluorescence. 
  • Trends in Anti-Vascular Endothelial Growth Factor Agents and Panretinal Photocoagulation Use in Diabetic Retinopathy. 
  • Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses. 
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  Keywords of People

  • Dhalla, Al-Hafeez Z, Assistant Research Professor in the Department of Biomedical Engineering, Biomedical Engineering
  • Ferguson, P. Lee, Associate Professor of Civil and Environmental Engineering, Civil and Environmental Engineering
  • Fischer, Martin, Research Professor in the Department of Chemistry, Chemistry
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering