Organophosphonates
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Subject Areas on Research
- A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.
- Accuracy of Self-Report and Pill-Count Measures of Adherence in the FEM-PrEP Clinical Trial: Implications for Future HIV-Prevention Trials.
- Activation of adenylate cyclase by phosphoramidate and phosphonate analogs of GTP: possible role of covalent enzyme-substrate intermediates in the mechanism of hormonal activation.
- Acute renal failure after initiation of tenofovir disoproxil fumarate.
- Adefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: final long-term results.
- Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation patients.
- Adenovirus causing fever, upper respiratory infection, and allograft nephritis complicated by persistent asymptomatic viremia.
- Alkenylation of C(sp3 )-H Bonds by Zincation/Copper-Catalyzed Cross-Coupling with Iodonium Salts.
- Antibody to hepatitis B surface antigen trough levels and half-lives do not differ after intravenous and intramuscular hepatitis B immunoglobulin administration after liver transplantation.
- Antiretroviral medications: adverse effects on the kidney.
- Antiretroviral preexposure prophylaxis for HIV prevention.
- Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure.
- Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD.
- Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial.
- Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial.
- Changes in proteinuria and albuminuria with initiation of antiretroviral therapy: data from a randomized trial comparing tenofovir disoproxil fumarate/emtricitabine versus abacavir/lamivudine.
- Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview.
- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives.
- Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.
- Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.
- Design of tenofovir-UC781 combination microbicide vaginal gels.
- Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.
- Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection.
- Evaluation of polyphosphates and polyphosphonates as degradable biomaterials.
- Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146.
- FEM-PrEP: adherence patterns and factors associated with adherence to a daily oral study product for pre-exposure prophylaxis.
- Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients.
- Hepatitis B virus viral load and treatment decision.
- High virological failure rate in HIV patients after switching to a regimen with two nucleoside reverse transcriptase inhibitors plus tenofovir.
- Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates.
- Infant growth outcomes after maternal tenofovir disoproxil fumarate use during pregnancy.
- Kidney disease in patients with HIV infection and AIDS.
- Kinetics of irreversible activation of adenylate cyclase of fat cell membranes by phosphonium and phosphoramidate analogs of gtp1.
- Leukotriene B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic phospholipase A2.
- Liver and renal safety of tenofovir disoproxil fumarate in combination with emtricitabine among African women in a pre-exposure prophylaxis trial.
- Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings.
- Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.
- Management of severe acute to fulminant hepatitis B: to treat or not to treat or when to treat?
- Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose.
- Multicompartmental pharmacokinetic model of tenofovir delivery by a vaginal gel.
- Newer treatments for HIV in children.
- Perception of HIV risk and adherence to a daily, investigational pill for HIV prevention in FEM-PrEP.
- Pharmacokinetics and safety of intravesicular cidofovir in allogeneic HSCT recipients.
- Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection.
- Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS.
- Pradefovir, a liver-targeted prodrug of adefovir against HBV infection.
- Preexposure prophylaxis for HIV infection among African women.
- Pregnancy and contraceptive use among women participating in the FEM-PrEP trial.
- Prevention of lamivudine-resistant hepatitis B recurrence after liver transplantation with entecavir plus tenofovir combination therapy and perioperative hepatitis B immunoglobulin only.
- Progressive multifocal leukoencephalopathy following heightened immunosuppression after lung transplant.
- Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal.
- Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss.
- Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients.
- Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated.
- Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users.
- Simplified maintenance therapy with abacavir/lamivudine/zidovudine plus tenofovir after sustained HIV load suppression: four years of follow-up.
- Sino-implant (II)® continuation and effect of concomitant tenofovir disoproxil fumarate-emtricitabine use on plasma levonorgestrel concentrations among women in Bondo, Kenya.
- Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children.
- Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques.
- Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency.
- Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.
- Synthesis of new classes of boron-containing nucleotides.
- Synthesis of oligonucleoside boranophosphates via an H-phosphonate method without nucleobase protection.
- Tenofovir alafenamide for HIV infection: is less more?
- The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo.
- The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years.
- The science of being a study participant: FEM-PrEP participants' explanations for overreporting adherence to the study pills and for the whereabouts of unused pills.
- The significance of antiretroviral-associated acute kidney injury in a cohort of ambulatory human immunodeficiency virus-infected patients.
- Towards establishing indicative values for metabolites of organophosphate ester contaminants in human urine.
- Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations.
- Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy.
- Vaginal deployment and tenofovir delivery by microbicide gels.
- Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated.
- [Acute hepatitis B: is antiviral therapy indicated? Two case reports].
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Keywords of People
- Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute