Ataxia Telangiectasia Mutated Proteins
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Subject Areas on Research
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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.
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A new role for ATM: regulating mitochondrial function and mitophagy.
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A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.
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A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.
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ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells.
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ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.
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ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks.
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ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations.
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ATM activation in normal human tissues and testicular cancer.
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ATM binds to beta-adaptin in cytoplasmic vesicles.
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ATM deficiency promotes progression of CRPC by enhancing Warburg effect.
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ATM functions at the peroxisome to induce pexophagy in response to ROS.
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ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation.
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
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ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.
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ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.
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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
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ATM--a key determinant of multiple cellular responses to irradiation.
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
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ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.
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ATM: genome stability, neuronal development, and cancer cross paths.
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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
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ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.
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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
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An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.
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Association of germline rare pathogenic mutations in guideline-recommended genes with prostate cancer progression: A meta-analysis.
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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.
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Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.
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Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.
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Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.
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Aven-dependent activation of ATM following DNA damage.
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Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
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Cell biology: A BID for the pathway.
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Cell cycle. Checking two steps.
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Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia.
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Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing.
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Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation.
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Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.
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Chromatin perturbations during the DNA damage response in higher eukaryotes.
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Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest.
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Combination ATR and PARP Inhibitor (CAPRI): A phase 2 study of ceralasertib plus olaparib in patients with recurrent, platinum-resistant epithelial ovarian cancer.
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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
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Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.
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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
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DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture.
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Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.
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Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors.
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Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.
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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
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Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
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Expression and assay of recombinant ATM.
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Fragments of ATM which have dominant-negative or complementing activity.
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Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma.
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Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX.
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Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.
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Genetic variations in the homologous recombination repair pathway genes modify risk of glioma.
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Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.
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Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death.
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Germline genetic variants in men with prostate cancer and one or more additional cancers.
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HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
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Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability.
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Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.
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Influence of ATM function on telomere metabolism.
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Inositol diphosphate signaling regulates telomere length.
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Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae.
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Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.
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Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.
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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.
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Ionizing radiation activates the ATM kinase throughout the cell cycle.
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Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism.
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Loss of atm radiosensitizes multiple p53 null tissues.
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Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
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Management of high, moderate, and low penetrance ovarian cancer susceptibility mutations: an assessment of current risk reduction practices.
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Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.
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Mitochondrial dysfunction in ataxia-telangiectasia.
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Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.
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Multiple signaling pathways involving ATM.
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N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.
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Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.
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Our cells get stressed too! Implications for human disease.
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PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
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Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
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Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
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Pharmacologic inhibition of ataxia telangiectasia and Rad3-related (ATR) in the treatment of head and neck squamous cell carcinoma.
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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
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Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.
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Prevalence of deleterious ATM germline mutations in gastric cancer patients.
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Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
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Protein phosphatase 5 is required for ATR-mediated checkpoint activation.
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Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.
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Pulmonary Granular Cell Tumors: A Study of 4 Cases Including a Malignant Phenotype.
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Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Rare germline mutations in African American men diagnosed with early-onset prostate cancer.
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Rationale and design of the safe and timely antithrombotic removal - ticagrelor (STAR-T) trial: A prospective, multi-center, double-blind, randomized controlled trial evaluating reductions in postoperative bleeding with intraoperative removal of ticagrelor by the drugsorb™-ATR device in patients undergoing cardiothoracic surgery within 48 hours from last ticagrelor dose.
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Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells.
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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
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Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia.
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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.
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SARS-CoV-2 triggers DNA damage response in Vero E6 cells.
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Salicylic acid activates DNA damage responses to potentiate plant immunity.
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Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells.
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Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
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Substrate specificities and identification of putative substrates of ATM kinase family members.
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Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
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Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
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Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients.
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The ATM-dependent DNA damage signaling pathway.
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The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
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The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.
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The many substrates and functions of ATM.
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The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
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Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation.
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Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.
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Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia.
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ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.
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p53 and ATM: cell cycle, cell death, and cancer.
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p53: a two-faced cancer gene.