Clustered Regularly Interspaced Short Palindromic Repeats
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Subject Areas on Research
- * CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments.
- A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
- A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish.
- AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.
- AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice.
- ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.
- Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine.
- An engineered ScCas9 with broad PAM range and high specificity and activity.
- Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment.
- Boosting, Not Breaking: CRISPR Activators Treat Disease Models.
- CRISPR Clocks: The Times They Are a-Changin'.
- CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
- CRISPR genome editing in stem cells turns to gold.
- CRISPR technology for gene therapy.
- CRISPR-Cas "Non-Target" Sites Inhibit On-Target Cutting Rates.
- CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
- CRISPR-Cas9-Guided Genome Engineering in C. elegans.
- CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.
- Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells.
- Control of muscle formation by the fusogenic micropeptide myomixer.
- Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.
- Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity.
- Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination.
- Enabling functional genomics with genome engineering.
- Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.
- Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression.
- Expanding the CRISPR Toolbox: Targeting RNA with Cas13b.
- From CRISPR scissors to virus sensors.
- GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells.
- Genetic engineering: Chemical control for CRISPR editing.
- High-Resolution Identification of Multiple Salmonella Serovars in a Single Sample by Using CRISPR-SeroSeq.
- Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
- Identification of an elaborate complex mediating postsynaptic inhibition.
- Immunity to Cas9 as an Obstacle to Persistent Genome Editing.
- In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.
- In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.
- In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
- In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
- In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
- Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease.
- Insights into the mechanisms underlying the inactivation of HIV-1 proviruses by CRISPR/Cas.
- Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
- Mammalian Synthetic Biology: Engineering Biological Systems.
- Optical Control of CRISPR/Cas9 Gene Editing.
- Pulling the genome in opposite directions to dissect gene networks.
- RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.
- RNA-guided gene activation by CRISPR-Cas9-based transcription factors.
- Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum.
- Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing.
- Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing.
- Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease.
- The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
- The next generation of CRISPR-Cas technologies and applications.
- The virology-RNA biology connection.
- Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation.
- ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.
- bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens.