CRISPR-Cas Systems
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Subject Areas on Research
- A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.
- A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes.
- A CRISPR/Cas9-based system for reprogramming cell lineage specification.
- A Decade of CRISPR-Cas Gnome Editing in C. elegans .
- A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells.
- A genetic memory initiates the epigenetic loop necessary to preserve centromere position.
- A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.
- A light-inducible CRISPR-Cas9 system for control of endogenous gene activation.
- A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.
- A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish.
- Advancing Functional Genetics Through Agrobacterium-Mediated Insertional Mutagenesis and CRISPR/Cas9 in the Commensal and Pathogenic Yeast Malassezia.
- An engineered ScCas9 with broad PAM range and high specificity and activity.
- An evolved AAV variant enables efficient genetic engineering of murine T cells.
- Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
- Boosting, Not Breaking: CRISPR Activators Treat Disease Models.
- Breakthrough Moments: Genome Editing and Organoids.
- CRISPR Clocks: The Times They Are a-Changin'.
- CRISPR Library Screening in Cultured Cardiomyocytes.
- CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
- CRISPR-Cas9-Guided Genome Engineering in C. elegans.
- CRISPR-Cas9-Guided Genome Engineering in Caenorhabditis elegans.
- CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.
- CRISPR-based methods for high-throughput annotation of regulatory DNA.
- CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues.
- CRISPR/Cas9 Mediated Deletion of the Angiotensinogen Gene Reduces Hypertension: A Potential for Cure?
- CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression.
- Cancer genes disfavoring T cell immunity identified via integrated systems approach.
- Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models.
- Centromere scission drives chromosome shuffling and reproductive isolation.
- Chemically induced proximity in biology and medicine.
- Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.
- Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.
- Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.
- Cut it out! A CRISPR-Cas9 screen identifies host regulators of the Plasmodium liver stage.
- Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.
- Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
- Editing the Epigenome: Reshaping the Genomic Landscape.
- Editing the epigenome: technologies for programmable transcription and epigenetic modulation.
- Editorial overview: Nucleic acids and their protein complexes: Progress in nucleic acid structural biology: new technologies and discoveries.
- Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual-Marker Selection Cassettes.
- Encapsulating Cas9 into extracellular vesicles by protein myristoylation.
- Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading.
- Engineering Delivery Vehicles for Genome Editing.
- Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression.
- Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.
- Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems.
- Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.
- Epigenome editing of the CFTR-locus for treatment of cystic fibrosis.
- Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging.
- Expanding the CRISPR Toolbox: Targeting RNA with Cas13b.
- Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.
- FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.
- From CRISPR scissors to virus sensors.
- Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy.
- GPER1 is required to protect fetal health from maternal inflammation.
- Gene Therapy 2017: Progress and Future Directions.
- Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.
- Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.
- Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.
- Genetic engineering: Chemical control for CRISPR editing.
- Genome Engineering for Personalized Arthritis Therapeutics.
- Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.
- Genome editing: the end of the beginning.
- Genome engineering: a new approach to gene therapy for neuromuscular disorders.
- Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.
- Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators.
- Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling.
- Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
- Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
- Immunity to Cas9 as an Obstacle to Persistent Genome Editing.
- In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.
- In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
- In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
- Increasing the specificity of CRISPR systems with engineered RNA secondary structures.
- Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient.
- Induction of an immortalized songbird cell line allows for gene characterization and knockout by CRISPR-Cas9.
- Infectious disease models in zebrafish.
- Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science.
- Jumping at the chance for precise DNA integration.
- Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking.
- Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish.
- Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives.
- Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.
- Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy.
- Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.
- MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
- Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.
- Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.
- Mating-Type-Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in Cryptococcus neoformans.
- Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
- Minimal PAM specificity of a highly similar SpCas9 ortholog.
- Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response.
- Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.
- Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector.
- Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators.
- N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.
- Optical Control of CRISPR/Cas9 Gene Editing.
- PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers.
- Pathogenesis Study of Enterovirus 71 Using a Novel Human SCARB2 Knock-In Mouse Model.
- Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering.
- Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter.
- Pulling the genome in opposite directions to dissect gene networks.
- RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.
- RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors.
- Racing for Academic Glory and Patents: Lessons from CRISPR
- Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.
- Rapid and reversible epigenome editing by endogenous chromatin regulators.
- Receptor Switching in Newly Evolved Adeno-associated Viruses.
- Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo.
- Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9.
- Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.
- Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia.
- Responsible Use of Human Gene-Editing Technologies.
- Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.
- Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators.
- SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.
- Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing.
- Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements.
- Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation.
- Silencing the porcine iGb3s gene does not affect Galα3Gal levels or measures of anticipated pig-to-human and pig-to-primate acute rejection.
- Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing.
- Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.
- Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis.
- Subtype-specific 3D genome alteration in acute myeloid leukaemia.
- Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers.
- Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.
- Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion.
- Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells.
- Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
- The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction.
- The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target.
- The next generation of CRISPR-Cas technologies and applications.
- These Are the Genes You're Looking For: Finding Host Resistance Genes.
- Transformation and CRISPR-Cas9-mediated homologous recombination in the fungus Rhizopus microsporus .
- Transgenic mice for in vivo epigenome editing with CRISPR-based systems.
- Unwinding the Role of FACT in Cas9-based Genome Editing.
- Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
- Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches.
- WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
- Wake-up call from Hong Kong.