Anaphase-Promoting Complex-Cyclosome
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Subject Areas on Research
- A cell cycle timer for asymmetric spindle positioning.
- A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.
- Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.
- Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.
- Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism.
- Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase.
- Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
- Not-so-pseudo a substrate: Acm1-mediated inhibition of the APC.
- Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.
- Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.
- SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo.
- Stalling in mitosis and releasing the apoptotic brake.
- Ubiquitylation of p53 by the APC/C inhibitor Trim39.