MEF2 Transcription Factors

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  Subject Areas on Research

  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Genetic loci for retinal arteriolar microcirculation. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization. 
  • Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. 
  • Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. 
  • Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. 
  • The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. 
  • The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. 
  • The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity. 
  • The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.