Healthy Volunteers

• 

  Subject Areas on Research

  • A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers. 
  • A Randomized Controlled Trial Investigating the Feasibility and Adherence to an Aerobic Training Program in Healthy Individuals. 
  • A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection. 
  • A hybrid proton and hyperpolarized gas tagging MRI technique for lung respiratory motion imaging: a feasibility study. 
  • A validation method for near-infrared spectroscopy based tissue oximeters for cerebral and somatic tissue oxygen saturation measurements. 
  • Accuracy of the Lifebox pulse oximeter during hypoxia in healthy volunteers. 
  • Activities of daily living influence tibial cartilage T1rho relaxation times. 
  • Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants. 
  • Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial. 
  • Aging effects on leg joint variability during walking with balance perturbations. 
  • An Ex Vivo Study to Evaluate the Effect of Tegaserod on Platelet Activation and Aggregation. 
  • Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid. 
  • Applying dynamic data collection to improve dry electrode system performance for a P300-based brain-computer interface. 
  • Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography. 
  • Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study. 
  • Bayesian nonparametric models characterize instantaneous strategies in a competitive dynamic game. 
  • Bedside ultrasound is a practical and reliable measurement tool for assessing quadriceps muscle layer thickness. 
  • Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research. 
  • Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial. 
  • COMPASS identifies T-cell subsets correlated with clinical outcomes. 
  • Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. 
  • Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin. 
  • Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control. 
  • Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults. 
  • Commanding a Brain-Controlled Wheelchair Using Steady-State Somatosensory Evoked Potentials. 
  • Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis. 
  • Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers. 
  • Compressed sensing reconstruction for undersampled breath-hold radial cine imaging with auxiliary free-breathing data. 
  • Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers. 
  • Controlled Multifactorial Coagulopathy: Effects of Dilution, Hypothermia, and Acidosis on Thrombin Generation In Vitro. 
  • Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children. 
  • Data analysis as a source of variability of the HLA-peptide multimer assay: from manual gating to automated recognition of cell clusters. 
  • Developing a standardized measurement of alcohol intoxication. 
  • Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes. 
  • Dietary methionine influences therapy in mouse cancer models and alters human metabolism. 
  • Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge. 
  • Distinctive Analysis of Macular Superficial Capillaries and Large Vessels Using Optical Coherence Tomographic Angiography in Healthy and Diabetic Eyes. 
  • Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet? 
  • Effect of Azithromycin on Venetoclax Pharmacokinetics in Healthy Volunteers: Implications for Dosing Venetoclax with P-gp Inhibitors. 
  • Effect of HAART on Brain Organization and Function in HIV-Negative Subjects. 
  • Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial. 
  • Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial. 
  • Elevated lidocaine serum levels following the use of a needle free device in healthy adult volunteers. 
  • Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling. 
  • Evaluating a program to increase blood donation among racial and ethnic minority communities in New York City. 
  • Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19). 
  • Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: repeatability and assessment of artifacts. 
  • Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI. 
  • Fixed volume particle trace emission for the analysis of left atrial blood flow using 4D Flow MRI. 
  • Four dimensional magnetic resonance imaging with retrospective k-space reordering: a feasibility study. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • GSK2374697, a long duration glucagon-like peptide-1 (GLP-1) receptor agonist, reduces postprandial circulating endogenous total GLP-1 and peptide YY in healthy subjects. 
  • Genetic polymorphisms of metabolic enzymes and the pharmacokinetics of indapamide in Taiwanese subjects. 
  • Genetically predicted circulating protein biomarkers and ovarian cancer risk. 
  • Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years of Age. 
  • Healthy Aging and Cardiovascular Function: Invasive Hemodynamics During Rest and Exercise in 104 Healthy Volunteers. 
  • High-frequency actionable pathogenic exome variants in an average-risk cohort. 
  • Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. 
  • Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). 
  • Identification of a serum microRNA expression signature for detection of lung cancer, involving miR-23b, miR-221, miR-148b and miR-423-3p. 
  • Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial. 
  • Impact of Normal Aging and Progression Definitions on the Specificity of Detecting Retinal Nerve Fiber Layer Thinning. 
  • Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives. 
  • In vivo three-dimensional characterization of the healthy human lamina cribrosa with adaptive optics spectral-domain optical coherence tomography. 
  • Individual-Specific, Beat-to-beat Trending of Significant Human Blood Loss: The Compensatory Reserve. 
  • Influence of editing pulse flip angle on J-difference MR spectroscopy. 
  • Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. 
  • Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study. 
  • Integrated parallel reception, excitation, and shimming (iPRES) with multiple shim loops per radio-frequency coil element for improved B0 shimming. 
  • Intravenous Gadoxetate Disodium Administration Reduces Breath-holding Capacity in the Hepatic Arterial Phase: A Multi-Center Randomized Placebo-controlled Trial. 
  • Longitudinal multi-omics of host-microbe dynamics in prediabetes. 
  • Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula. 
  • Male obesity impacts DNA methylation reprogramming in sperm. 
  • Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis. 
  • Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects. 
  • Methylphenidate increases willingness to perform effort in adults with ADHD. 
  • Motion immune diffusion imaging using augmented MUSE for high-resolution multi-shot EPI. 
  • Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers. 
  • Multifactorial assessment of measurement errors affecting intraoral quantitative sensory testing reliability. 
  • Muscle Deoxygenation and Its Heterogeneity Changes After Endurance Training. 
  • Neuropsychological profile in adult schizophrenia measured with the CMINDS. 
  • Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults. 
  • Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus. 
  • Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study. 
  • Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study. 
  • Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects. 
  • Perception of clinical research among patients and healthy volunteers of clinical trials. 
  • Perceptions of Equipoise, Risk-Benefit Ratios, and "Otherwise Healthy Volunteers" in the Context of Early-Phase HIV Cure Research in the United States: A Qualitative Inquiry. 
  • Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects. 
  • Pharmacokinetics of the BCL-2 Inhibitor Venetoclax in Healthy Chinese Subjects. 
  • Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects. 
  • Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses of CN-105 in Healthy Adult Subjects. 
  • Phase-1 clinical trial results of high-specific-activity carrier-free 123I-iobenguane. 
  • Population pharmacokinetics of NNZ-2566 in healthy subjects. 
  • Postural Stability Under Dual-Task Conditions: Development of a Post-Concussion Assessment for Lower-Extremity Injury Risk. 
  • Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels. 
  • Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. 
  • Qualitative and Quantitative Analysis of the Corneal Endothelium With Smartphone Specular Microscopy. 
  • Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2 -based oxygenation calibrations. 
  • Quantifying Skin Stiffness in Graft-Versus-Host Disease, Morphea, and Systemic Sclerosis Using Acoustic Radiation Force Impulse Imaging and Shear Wave Elastography. 
  • Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. 
  • Racially diverse participant registries to facilitate the recruitment of African Americans into presymptomatic Alzheimer's disease studies. 
  • Randomized Controlled Trial Evaluating Aerobic Training and Common Sport-Related Concussion Outcomes in Healthy Participants. 
  • Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial. 
  • Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes. 
  • Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. 
  • Reevaluating Order Effects in the Binaural Bithermal Caloric Test. 
  • Relationship Between Peripapillary Choroid and Retinal Nerve Fiber Layer Thickness in a Population-Based Sample of Nonglaucomatous Eyes. 
  • Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma. 
  • Relationship of ocular and systemic factors to the visibility of choroidal-scleral interface using spectral domain optical coherence tomography. 
  • Repeatability and Reproducibility of Quantification of Superficial Peri-papillary Capillaries by four Different Optical Coherence Tomography Angiography Devices. 
  • Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging Optical Coherence Tomography Using Different Posterior Boundaries. 
  • Reproducibility of blood pressure dipping: relation to day-to-day variability in sleep quality. 
  • Reproducibility of the correlative triad among aging, dopamine receptor availability, and cognition. 
  • Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers. 
  • Rivaroxaban reversal with prothrombin complex concentrate or tranexamic acid in healthy volunteers. 
  • Safety and Immunogenicity of a Respiratory Syncytial Virus Fusion (F) Protein Nanoparticle Vaccine in Healthy Third-Trimester Pregnant Women and Their Infants. 
  • Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis. 
  • Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study. 
  • Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines. 
  • Safety of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase I, Open-Label Study in Healthy Adult Volunteers. 
  • Safety, Tolerability, and Pharmacokinetics of NTM-1632, a Novel Mixture of Three Monoclonal Antibodies against Botulinum Toxin B. 
  • Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study. 
  • Serological response following re-vaccination with Salmonella typhi Vi-capsular polysaccharide vaccines in healthy adult travellers. 
  • Sleep-wake classification via quantifying heart rate variability by convolutional neural network. 
  • Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults. 
  • Sonographic evaluation of lumbar interlaminar space opening in a variety of patient body positions for optimal neuraxial anesthesia delivery. 
  • Spontaneous Eye Blink Rate (EBR) Is Uncorrelated with Dopamine D2 Receptor Availability and Unmodulated by Dopamine Agonism in Healthy Adults. 
  • Steady-state bioavailability of extended-release methylphenidate (MPH-MLR) capsule vs. immediate-release methylphenidate tablets in healthy adult volunteers. 
  • Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers. 
  • Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. 
  • Testing Assumptions in Human Pain Models: Psychophysical Differences Between First and Second Pain. 
  • The Association Between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect, and Healthy Eyes. 
  • The Binding Mechanisms of Antibodies to DNA from Healthy Subjects and Patients with Systemic Lupus Erythematosus: The Role of Monogamous Bivalency and Fc Dependence. 
  • The Diagnosis and Management of Patients with Renal Colic across a Sample of US Hospitals: High CT Utilization Despite Low Rates of Admission and Inpatient Urologic Intervention. 
  • The Effects of Passive Cycling Exercise for 20 min on Cardiorespiratory Dynamics in Healthy Men [corrected]. 
  • The Function Biomedical Informatics Research Network Data Repository. 
  • The accuracy of a near-infrared spectroscopy cerebral oximetry device and its potential value for estimating jugular venous oxygen saturation. 
  • The effect of repeated measurements and the use of topical anesthetic on rebound tonometry values in children. 
  • The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. 
  • The homozygous CX3CR1-M280 mutation impairs human monocyte survival. 
  • The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects. 
  • Three-Dimensional Characterization of Trabecular Bone Mineral Density of the Distal Radius Utilizing Quantitative Computed Tomography. 
  • Three-Year Durability of Immune Responses Induced by HIV-DNA and HIV-Modified Vaccinia Virus Ankara and Effect of a Late HIV-Modified Vaccinia Virus Ankara Boost in Tanzanian Volunteers. 
  • Tolerability and Pharmacokinetics of Single Escalating and Repeated Doses of CN-105 in Healthy Participants. 
  • Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution. 
  • Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation.