Checkpoint Kinase 2

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  Subject Areas on Research

  • A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer. 
  • A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer. 
  • An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. 
  • Association of germline rare pathogenic mutations in guideline-recommended genes with prostate cancer progression: A meta-analysis. 
  • Cell cycle. Checking two steps. 
  • Checkpoints couple transcription network oscillator dynamics to cell-cycle progression. 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer. 
  • Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. 
  • Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. 
  • Genetic insights into biological mechanisms governing human ovarian ageing. 
  • Germline genetic variants in men with prostate cancer and one or more additional cancers. 
  • Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer. 
  • Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. 
  • Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. 
  • Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate. 
  • Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. 
  • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. 
  • Polymorphic hCHK2/hCds1 codon 84 allele and risk of squamous cell carcinoma of the head and neck--a case-control analysis. 
  • Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. 
  • Response to bipolar androgen therapy and PD-1 inhibition in a patient with metastatic castration-resistant prostate cancer and a germline CHEK2 mutation. 
  • Sad1 Spatiotemporally Regulates Kinetochore Clustering To Ensure High-Fidelity Chromosome Segregation in the Human Fungal Pathogen Cryptococcus neoformans. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia.