Pragmatic Clinical Trials as Topic

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  Subject Areas on Research

  • A Community-based Assessment of Skin Care, Allergies, and Eczema (CASCADE): an atopic dermatitis primary prevention study using emollients-protocol for a randomized controlled trial. 
  • A national strategy to develop pragmatic clinical trials infrastructure. 
  • Adaptation and Implementation of a Family Caregiver Skills Training Program: From Single Site RCT to Multisite Pragmatic Intervention. 
  • Addressing guideline and policy changes during pragmatic clinical trials. 
  • Adherence to adding inhaled corticosteroids to rescue therapy in a pragmatic trial with adults with asthma: A pilot study. 
  • Administrative claims data to support pragmatic clinical trial outcome ascertainment on cardiovascular health. 
  • BeatPain Utah: study protocol for a pragmatic randomised trial examining telehealth strategies to provide non-pharmacologic pain care for persons with chronic low back pain receiving care in federally qualified health centers. 
  • Better Knee, Better Me™: effectiveness of two scalable health care interventions supporting self-management for knee osteoarthritis - protocol for a randomized controlled trial. 
  • Clinician engagement in the ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) trial. 
  • Comparison of Approaches for Notification and Authorization in Pragmatic Clinical Research Evaluating Commonly Used Medical Practices. 
  • Comparison of International Guidelines for Assessment of Suspected Stable Angina: Insights From the PROMISE and SCOT-HEART. 
  • Computable Phenotype Implementation for a National, Multicenter Pragmatic Clinical Trial: Lessons Learned From ADAPTABLE. 
  • Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial. 
  • Deriving Real-World Insights From Real-World Data: Biostatistics to the Rescue. 
  • Design and Rationale of HiLo: A Pragmatic, Randomized Trial of Phosphate Management for Patients Receiving Maintenance Hemodialysis. 
  • Design and analytic considerations for using patient-reported health data in pragmatic clinical trials: report from an NIH Collaboratory roundtable. 
  • Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy - the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial. 
  • Developing lay summaries and thank you notes in paediatric pragmatic clinical trials. 
  • Effects of obesity on noninvasive test results in patients with suspected cardiac ischemia: Insights from the PROMISE trial. 
  • Electronic health records based phenotyping in next-generation clinical trials: a perspective from the NIH Health Care Systems Collaboratory. 
  • Ethical and epistemic issues in the design and conduct of pragmatic stepped-wedge cluster randomized clinical trials. 
  • Ethics and Collateral Findings in Pragmatic Clinical Trials. 
  • Evidence from Pragmatic Trials during Routine Care - Slouching toward a Learning Health System. 
  • Expanding Evidence for Clinical Care of Older Adults: Beyond Clinical Trial Traditions and Finding New Approaches. 
  • FDA-Catalyst-Using FDA's Sentinel Initiative for large-scale pragmatic randomized trials: Approach and lessons learned during the planning phase of the first trial. 
  • Feasibility of Using Real-world Data to Emulate Postapproval Confirmatory Clinical Trials of Therapeutic Agents Granted US Food and Drug Administration Accelerated Approval. 
  • Five analytic challenges in working with electronic health records data to support clinical trials with some solutions. 
  • Heart Watch Study: protocol for a pragmatic randomised controlled trial. 
  • Identification and management of pragmatic clinical trial collateral findings: A current understanding and directions for future research. 
  • Incentives and payments in pragmatic clinical trials: Scientific, ethical, and policy considerations. 
  • Innovative design and analysis for rare disease drug development. 
  • Intervention design in cognitively impaired populations-Lessons learned from the OPTIMIZE deprescribing pragmatic trial. 
  • Is Learning Worth the Trouble? - Improving Health Care System Participation in Embedded Research. 
  • Iterative approaches to the use of electronic health records data for large pragmatic studies. 
  • Learning From What We Do, and Doing What We Learn: A Learning Health Care System in Action. 
  • Leave me out: Patients' characteristics and reasons for opting out of a pragmatic clinical trial involving medication adherence. 
  • Lessons Learned Using Real-World Data to Emulate Randomized Trials: A Case Study of Treatment Effectiveness for Newly Diagnosed Immune Thrombocytopenia. 
  • Leveraging electronic health record data for pragmatic randomized trials. 
  • Low risk pragmatic trials do not always require participants' informed consent. 
  • Making Clinical Practice Guidelines Pragmatic: How Big Data and Real World Evidence Can Close the Gap. 
  • Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory. 
  • PCORnet® 2020: current state, accomplishments, and future directions. 
  • Patients' Views Concerning Research on Medical Practices: Implications for Consent. 
  • Persistent Methicilin-Resistant Staphylococcus aureus Bacteremia: Resetting the Clock for Optimal Management. 
  • Physicians' perspectives regarding pragmatic clinical trials. 
  • Practical challenges in the conduct of pragmatic trials embedded in health plans: Lessons of IMPACT-AFib, an FDA-Catalyst trial. 
  • Pragmatic (trial) informatics: a perspective from the NIH Health Care Systems Research Collaboratory. 
  • Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory. 
  • Pragmatic clinical trials offer unique opportunities for disseminating, implementing, and sustaining evidence-based practices into clinical care: Proceedings of a workshop. 
  • Protocolized Post-Extubation Respiratory Support to prevent reintubation: protocol and statistical analysis plan for a clinical trial. 
  • Public views regarding the responsibility of patients, clinicians, and institutions to participate in research in the United States. 
  • Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students. 
  • Registry-based trials: a potential model for cost savings? 
  • Responding to signals of mental and behavioral health risk in pragmatic clinical trials: Ethical obligations in a healthcare ecosystem. 
  • Role of health plan administrative claims data in participant recruitment for pragmatic clinical trials: An Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE) example. 
  • Streamlining the institutional review board process in pragmatic randomized clinical trials: challenges and lessons learned from the Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness (ADAPTABLE) trial. 
  • Study protocol for targeted interventions to prevent chronic low back pain in high-risk patients: A multi-site pragmatic cluster randomized controlled trial (TARGET Trial). 
  • The ADAPTABLE Trial and PCORnet: Shining Light on a New Research Paradigm. 
  • The Changing Landscape of Randomized Clinical Trials in Cardiovascular Disease. 
  • The Disruptive bEhavior manageMEnt ANd prevention in hospitalized patients using a behaviORal intervention team (DEMEANOR) study protocol: a pragmatic, cluster, crossover trial. 
  • The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial. 
  • The Head and Neck Survivorship Tool (HN-STAR) Trial (WF-1805CD): A protocol for a cluster-randomized, hybrid effectiveness-implementation, pragmatic trial to improve the follow-up care of head and neck cancer survivors. 
  • The OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial. 
  • The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory. 
  • The yin and yang of pragmatic clinical trials of behavioral interventions for chronic pain: balancing design features to maximize impact. 
  • Thoughtful selection and use of scientific terms in clinical research: the case of 'pragmatic' trials. 
  • Traditional Chinese medicine (TCM) collaborative care for patients with axial spondyloarthritis (AcuSpA): protocol for a pragmatic randomized controlled trial. 
  • University of Pennsylvania 12th annual conference on statistical issues in clinical trials: Electronic health records in randomized clinical trials-challenges and opportunities (morning panel session). 
  • University of Pennsylvania eighth annual conference on statistical issues in clinical trials: Pragmatic clinical trials (afternoon panel). 
  • Weighing the Benefits and Risks of Proliferating Observational Treatment Assessments: Observational Cacophony, Randomized Harmony. 
  • When Are Treatment Blinding and Treatment Standardization Necessary in Real-World Clinical Trials?