Cell- and Tissue-Based Therapy

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  Subject Areas on Research

  • A cord blood monocyte-derived cell therapy product accelerates brain remyelination. 
  • A tutorial on the use of exploratory efficacy outcomes in uncontrolled phase I cell therapy trials. 
  • An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. 
  • Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells. 
  • Apoptotic Donor Cells in Transplantation. 
  • Apoptotic cell-based therapies for promoting transplantation tolerance. 
  • Applications of Gene Editing Technologies to Cellular Therapies. 
  • Autologous CD34+ Cell Therapy for Refractory Angina: 2-Year Outcomes From the ACT34-CMI Study. 
  • Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial. 
  • Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial. 
  • Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature. 
  • Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review. 
  • Biobehavioral Research and Hematopoietic Stem Cell Transplantation: Expert Review from the Biobehavioral Research Special Interest Group of the American Society for Transplantation and Cellular Therapy. 
  • Cardiac regeneration. 
  • Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors. 
  • Cell therapy for heart failure: the need for a new therapeutic strategy. 
  • Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. 
  • Cell-based gene therapy for repair of critical size defects in the rat fibula. 
  • Cell-based interventions for neurologic conditions: ethical challenges for early human trials. 
  • Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome. 
  • Cellular Therapies in Solid Organ Allotransplantation: Promise and Pitfalls. 
  • Chemically induced proximity in biology and medicine. 
  • Chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma. 
  • Comparison of Cilta-cel, an Anti-BCMA CAR-T Cell Therapy, Versus Conventional Treatment in Patients With Relapsed/Refractory Multiple Myeloma. 
  • Current perspectives on the use of ancillary materials for the manufacture of cellular therapies. 
  • DTI Tract-Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients During Autologous Cord Blood Cell Therapy Using a Rotationally-Invariant Quantitative Measure. 
  • Delivery of Synthetic mRNA Encoding FOXP3 Antigen into Dendritic Cells for Inflammatory Breast Cancer Immunotherapy. 
  • Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy. 
  • Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers. 
  • Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally?: An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial. 
  • Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial. 
  • Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis. 
  • Efficient intratracheal delivery of airway epithelial cells in mice and pigs. 
  • Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies. 
  • Epidermal growth factor receptor and variant III targeted immunotherapy. 
  • Genome engineering: a new approach to gene therapy for neuromuscular disorders. 
  • Genome-editing Technologies for Gene and Cell Therapy. 
  • Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models. 
  • Immunotherapy for Glioblastoma: Adoptive T-cell Strategies. 
  • Injectable biomaterial shuttles for cell therapy in stroke. 
  • Interneurons from embryonic development to cell-based therapy. 
  • IxCELL-DCM: rejuvenation for cardiac regenerative therapy? 
  • Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices. 
  • Migration of human dendritic cells after injection in patients with metastatic malignancies. 
  • Motor function and safety after allogeneic cord blood and cord tissue-derived mesenchymal stromal cells in cerebral palsy: An open-label, randomized trial. 
  • Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering. 
  • Patient-reported quality of life after tisagenlecleucel infusion in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: a global, single-arm, phase 2 trial. 
  • Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited metabolic diseases. 
  • RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors. 
  • Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. 
  • Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. 
  • Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. 
  • Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy. 
  • Standardization, workforce development and advocacy in cell and gene therapies: a summary of the 2020 Regenerative Medicine InterCHANGE. 
  • Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain. 
  • The (Pluri)Potential of Cell Therapy for Heart Failure. 
  • The (Translational) Road Less Traveled. 
  • The Landscape of Cell and Gene Therapies for Solid Tumors. 
  • The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections. 
  • Therapy with Cardiomyocytes Derived from Pluripotent Cells in Chronic Chagasic Cardiomyopathy.