Catechol O-Methyltransferase Inhibitors
Subject Areas on Research
- Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat.
- Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
- Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase.
- Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice.
- Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors.
- Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity.
- Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.
- β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.