CCR5 Receptor Antagonists

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  Subject Areas on Research

  • Acute graft-versus-host disease: are we close to bringing the bench to the bedside? 
  • Chemokine receptors and human immunodeficiency virus infection. 
  • Genotypic analysis of the V3 region of HIV from virologic nonresponders to maraviroc-containing regimens reveals distinct patterns of failure. 
  • HIV entry inhibitors: progress in development and application. 
  • HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells. 
  • High-resolution, noninvasive longitudinal live imaging of immune responses. 
  • Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector. 
  • Isolation and structure of antagonists of chemokine receptor (CCR5). 
  • Reliable genotypic tropism tests for the major HIV-1 subtypes. 
  • Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry.