Endothelin A Receptor Antagonists

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  Subject Areas on Research

  • Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude. 
  • Detection of previously unidentified metastatic disease as a leading cause of screening failure in a phase III trial of zibotentan versus placebo in patients with nonmetastatic, castration resistant prostate cancer. 
  • EndothelinA receptor antagonist BSF-208075 causes immune modulation and neuroprotection after stroke in gerbils. 
  • Pharmacologic renoprotection: are the stars finally moving into alignment? 
  • Phase 3, randomized, placebo-controlled study of zibotentan (ZD4054) in patients with castration-resistant prostate cancer metastatic to bone. 
  • Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial.