Cellular Reprogramming

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  Subject Areas on Research

  • A CRISPR/Cas9-based system for reprogramming cell lineage specification. 
  • A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens. 
  • A novel Cbx1, PurB, and Sp3 complex mediates long-term silencing of tissue- and lineage-specific genes. 
  • ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming. 
  • Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming. 
  • Apoptotic caspases regulate induction of iPSCs from human fibroblasts. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B. 
  • Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion. 
  • Delayed transition to new cell fates during cellular reprogramming. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Developmental Morphogens & Recovery from Alcoholic Liver Disease. 
  • Direct reprogramming of cardiac fibroblasts to cardiomyocytes using microRNAs. 
  • Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. 
  • Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. 
  • Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression. 
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. 
  • Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. 
  • Glycolytic reprogramming in cancer cells: PKM2 dimer predominance induced by pulsatile PFK-1 activity. 
  • HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation. 
  • Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • High-Efficiency Cellular Reprogramming by Nanoscale Puncturing. 
  • Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. 
  • In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia. 
  • Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies. 
  • Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology. 
  • Leukaemia: a model metastatic disease. 
  • Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes. 
  • Mesenchymal stromal cells reprogram monocytes and macrophages with processing bodies. 
  • Metabolic landscape of the tumor microenvironment at single cell resolution. 
  • MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function. 
  • MicroRNAs and Cardiac Regeneration. 
  • Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting. 
  • Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond. 
  • Optimizing delivery for efficient cardiac reprogramming. 
  • Production of Cardiomyocytes by microRNA-Mediated Reprogramming in Optimized Reprogramming Media. 
  • RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells. 
  • Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors. 
  • Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood. 
  • Regeneration of fat cells from myofibroblasts during wound healing. 
  • Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. 
  • Reprogramming after chromosome transfer into mouse blastomeres. 
  • Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. 
  • Reprogramming of cellular metabolic pathways by human oncogenic viruses. 
  • Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection. 
  • Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog. 
  • Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. 
  • Single-molecule analysis of myocyte differentiation reveals bimodal lineage commitment. 
  • Stem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts. 
  • Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. 
  • Synthetic transcription factors for cell fate reprogramming. 
  • Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. 
  • The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. 
  • Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs. 
  • Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.