Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., McGill University (Canada) 2011
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Mathematics, Mathematics, Trinity College of Arts & Sciences 2018 - 2021
  • Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2018 - 2020
  • Instructor in the Department of Population Health Sciences, Population Health Sciences, Basic Science Departments 2018
  • Instructor of Mathematics, Mathematics, Trinity College of Arts & Sciences 2018
  • Visiting Assistant Professor in the Department of Mathematics, Mathematics, Trinity College of Arts & Sciences 2012 - 2015
  • Visiting Assistant Professor in the Department of Surgery, Surgical Oncology, Surgery 2015
• Recognition
• 

  In the News

  • MAR 4, 2022

    Duke Health News

    Study Estimates One in Seven U.S. Breast Cancers May Be Over-Diagnosed

  • JUN 19, 2019

    Duke Research Blog

    Overdiagnosis and the Future of Cancer Medicine

  • MAY 22, 2018

    NIH Director's Blog

    Are Some Tumors Just ‘Born to Be Bad’?
• Research
• 

  Selected Grants

  • Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort awarded by Breast Cancer Research Foundation 2021 - 2022
  • Comparative Modeling for the Prevention and Control of Uterine Cancer awarded by Columbia University 2021 - 2022
  • The Mathematics of Breast Cancer Overtreatment: Improving Treatment Choice through Effective Communication of Personalized Cancer Risk awarded by National Institutes of Health 2018 - 2022
  • Modeling to Minimize Detection Bias in Cancer Risk Prediction Studies awarded by Fred Hutchinson Cancer Research Center 2019 - 2022
  • Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort awarded by Breast Cancer Research Foundation 2020 - 2021
  • Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort awarded by Breast Cancer Research Foundation 2019 - 2020
  • Mathematical Analysis of Spatial Cancer Models awarded by  National Science Foundation 2016 - 2020
  • Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort awarded by Breast Cancer Research Foundation 2018 - 2019
  • The Mathematics of Breast Cancer Overtreatment: Improving Treatment Choice through Effective Communication of Personalized Cancer Risk awarded by National Institutes of Health 2016 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ryser, Marc D., Jane Lange, Lurdes Y. T. Inoue, Ellen S. O’Meara, Charlotte Gard, Diana L. Miglioretti, Jean-Luc Bulliard, Andrew F. Brouwer, E Shelley Hwang, and Ruth B. Etzioni. “Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.” Ann Intern Med 175, no. 4 (April 2022): 471–78. https://doi.org/10.7326/M21-3577.
       Full Text  Link to Item
    • Seijen, Maartje van, Esther H. Lips, Liping Fu, Daniele Giardiello, Frederieke van Duijnhoven, Linda de Munck, Lotte E. Elshof, et al. “Long-term risk of subsequent ipsilateral lesions after surgery with or without radiotherapy for ductal carcinoma in situ of the breast.” Br J Cancer 125, no. 10 (November 2021): 1443–49. https://doi.org/10.1038/s41416-021-01496-6.
       Full Text  Link to Item
    • Murgas, Kevin A., Yanlin Ma, Lidea K. Shahidi, Sayan Mukherjee, Andrew S. Allen, Darryl Shibata, and Marc D. Ryser. “A Bayesian Hierarchical Model to Estimate DNA Methylation Conservation in Colorectal Tumors.” Bioinformatics, September 6, 2021. https://doi.org/10.1093/bioinformatics/btab637.
       Full Text  Link to Item
    • Rodriguez-Homs, Larissa G., Bradley G. Hammill, Marc D. Ryser, Harry R. Phillips, and Paul J. Mosca. “Relationship Between HCAHPS Scores and Survey Response Rate Is Linked to Hospital Size.” J Patient Exp 7, no. 6 (December 2020): 1543–48. https://doi.org/10.1177/2374373520932458.
       Full Text  Link to Item
    • Brouwer, Andrew F., Kevin He, Steven B. Chinn, Alison M. Mondul, Christina H. Chapman, Marc D. Ryser, Mousumi Banerjee, Marisa C. Eisenberg, Rafael Meza, and Jeremy M. G. Taylor. “Time-varying survival effects for squamous cell carcinomas at oropharyngeal and nonoropharyngeal head and neck sites in the United States, 1973-2015.” Cancer 126, no. 23 (December 1, 2020): 5137–46. https://doi.org/10.1002/cncr.33174.
       Full Text  Link to Item
    • Butt, Julia, William J. Blot, Kala Visvanathan, Loïc Le Marchand, Lynne R. Wilkens, Yu Chen, Howard D. Sesso, et al. “Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a U.S. Prospective Cohort Consortium.” Cancer Epidemiol Biomarkers Prev 29, no. 12 (December 2020): 2729–34. https://doi.org/10.1158/1055-9965.EPI-20-0780.
       Full Text  Link to Item
    • Epplein, Meira, Loïc Le Marchand, Timothy L. Cover, Mingyang Song, William J. Blot, Richard M. Peek, Lauren R. Teras, et al. “Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer.” Microorganisms 8, no. 11 (October 30, 2020). https://doi.org/10.3390/microorganisms8111698.
       Full Text  Link to Item
    • Shehata, Mariam N., Habib Rahbar, Meghan R. Flanagan, Mark R. Kilgore, Christoph I. Lee, Marc D. Ryser, and Kathryn P. Lowry. “Risk for Upgrade to Malignancy After Breast Core Needle Biopsy Diagnosis of Lobular Neoplasia: A Systematic Review and Meta-Analysis.” J Am Coll Radiol 17, no. 10 (October 2020): 1207–19. https://doi.org/10.1016/j.jacr.2020.07.036.
       Full Text  Link to Item
    • Williamson, Theresa, Marc D. Ryser, Peter A. Ubel, Jihad Abdelgadir, Charis A. Spears, Beiyu Liu, Jordan Komisarow, Monica E. Lemmon, Aladine Elsamadicy, and Shivanand P. Lad. “Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury.” Jama Surg 155, no. 8 (August 1, 2020): 723–31. https://doi.org/10.1001/jamasurg.2020.1790.
       Full Text  Link to Item
    • Chootipongchaivat, Sarocha, Nicolien T. van Ravesteyn, Xiaoxue Li, Hui Huang, Harald Weedon-Fekjær, Marc D. Ryser, Donald L. Weaver, et al. “Modeling the natural history of ductal carcinoma in situ based on population data.” Breast Cancer Res 22, no. 1 (May 27, 2020): 53. https://doi.org/10.1186/s13058-020-01287-6.
       Full Text  Link to Item
    • Rozenblatt-Rosen, Orit, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E. Rood, Orr Ashenberg, et al. “The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.” Cell 181, no. 2 (April 16, 2020): 236–49. https://doi.org/10.1016/j.cell.2020.03.053.
       Full Text  Open Access Copy  Link to Item
    • Ryser, Marc D., Diego Mallo, Allison Hall, Timothy Hardman, Lorraine M. King, Sergei Tatishchev, Inmaculada C. Sorribes, et al. “Minimal barriers to invasion during human colorectal tumor growth.” Nat Commun 11, no. 1 (March 9, 2020): 1280. https://doi.org/10.1038/s41467-020-14908-7.
       Full Text  Link to Item
    • Ryser, Marc D., and E Shelley Hwang. “Response to Habel and Buist.” J Natl Cancer Inst 112, no. 2 (February 1, 2020): 216–17. https://doi.org/10.1093/jnci/djz120.
       Full Text  Link to Item
    • Williamson, Theresa, Marc D. Ryser, Jihad Abdelgadir, Monica Lemmon, Mary Carol Barks, Rasheedat Zakare, and Peter A. Ubel. “Surgical decision making in the setting of severe traumatic brain injury: A survey of neurosurgeons.” Plos One 15, no. 3 (2020): e0228947. https://doi.org/10.1371/journal.pone.0228947.
       Full Text  Link to Item
    • Ryser, Marc D., Donald L. Weaver, Fengmin Zhao, Mathias Worni, Lars J. Grimm, Roman Gulati, Ruth Etzioni, Terry Hyslop, Sandra J. Lee, and E Shelley Hwang. “Cancer Outcomes in DCIS Patients Without Locoregional Treatment.” J Natl Cancer Inst 111, no. 9 (September 1, 2019): 952–60. https://doi.org/10.1093/jnci/djy220.
       Full Text  Link to Item
    • Ryser, Marc D., Laura H. Hendrix, Mathias Worni, Yiling Liu, Terry Hyslop, and E Shelley Hwang. “Incidence of Ductal Carcinoma In Situ in the United States, 2000-2014.” Cancer Epidemiol Biomarkers Prev 28, no. 8 (August 2019): 1316–23. https://doi.org/10.1158/1055-9965.EPI-18-1262.
       Full Text  Link to Item
    • Grimm, Lars J., Matthew M. Miller, Samantha M. Thomas, Yiling Liu, Joseph Y. Lo, E Shelley Hwang, Terry Hyslop, and Marc D. Ryser. “Growth Dynamics of Mammographic Calcifications: Differentiating Ductal Carcinoma in Situ from Benign Breast Disease.” Radiology 292, no. 1 (July 2019): 77–83. https://doi.org/10.1148/radiol.2019182599.
       Full Text  Link to Item
    • Shen, Yu, Wenli Dong, Roman Gulati, Marc D. Ryser, and Ruth Etzioni. “Estimating the frequency of indolent breast cancer in screening trials.” Stat Methods Med Res 28, no. 4 (April 2019): 1261–71. https://doi.org/10.1177/0962280217754232.
       Full Text  Link to Item
    • Ryser, Marc D., Roman Gulati, Marisa C. Eisenberg, Yu Shen, E Shelley Hwang, and Ruth B. Etzioni. “Identification of the Fraction of Indolent Tumors and Associated Overdiagnosis in Breast Cancer Screening Trials.” Am J Epidemiol 188, no. 1 (January 1, 2019): 197–205. https://doi.org/10.1093/aje/kwy214.
       Full Text  Link to Item
    • Ryser, Marc D., Ming Yu, William Grady, Kimberly Siegmund, and Darryl Shibata. “Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance.” Sci Rep 8, no. 1 (November 23, 2018): 17292. https://doi.org/10.1038/s41598-018-35621-y.
       Full Text  Link to Item
    • Ryser, Marc D., Byung-Hoon Min, Kimberly D. Siegmund, and Darryl Shibata. “Spatial mutation patterns as markers of early colorectal tumor cell mobility.” Proc Natl Acad Sci U S A 115, no. 22 (May 29, 2018): 5774–79. https://doi.org/10.1073/pnas.1716552115.
       Full Text  Link to Item
    • Grimm, Lars J., Marc D. Ryser, and Terry Hyslop. “Role of Preoperative Variables in Reducing the Rate of Occult Invasive Disease for Women Considering Active Surveillance for Ductal Carcinoma In Situ.” Jama Surg 153, no. 3 (March 1, 2018): 290–91. https://doi.org/10.1001/jamasurg.2017.5566.
       Full Text  Link to Item
    • Ryser, Marc D., Janet K. Horton, and E Shelley Hwang. “How Low Can We Go-and Should We? Risk Reduction for Minimal-Volume DCIS.” Ann Surg Oncol 25, no. 2 (February 2018): 354–55. https://doi.org/10.1245/s10434-017-6128-4.
       Full Text  Link to Item
    • Grimm, Lars J., Marc D. Ryser, Ann H. Partridge, Alastair M. Thompson, Jeremy S. Thomas, Jelle Wesseling, and E Shelley Hwang. “Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials.” Ann Surg Oncol 24, no. 12 (November 2017): 3534–40. https://doi.org/10.1245/s10434-017-6018-9.
       Full Text  Link to Item
    • Cao, Yangxiaolu, Yaying Feng, Marc D. Ryser, Kui Zhu, Gregory Herschlag, Changyong Cao, Katherine Marusak, Stefan Zauscher, and Lingchong You. “Programmable assembly of pressure sensors using pattern-forming bacteria.” Nat Biotechnol 35, no. 11 (November 2017): 1087–93. https://doi.org/10.1038/nbt.3978.
       Full Text  Link to Item
    • Ryser, Marc D., Anne Rositch, and Patti E. Gravitt. “Modeling of US Human Papillomavirus (HPV) Seroprevalence by Age and Sexual Behavior Indicates an Increasing Trend of HPV Infection Following the Sexual Revolution.” J Infect Dis 216, no. 5 (September 1, 2017): 604–11. https://doi.org/10.1093/infdis/jix333.
       Full Text  Link to Item
    • Ryser, Marc D., Patti E. Gravitt, and Evan R. Myers. “Mechanistic mathematical models: An underused platform for HPV research.” Papillomavirus Res 3 (June 2017): 46–49. https://doi.org/10.1016/j.pvr.2017.01.004.
       Full Text  Link to Item
    • Ryser, Marc D., and Kevin A. Murgas. “Bone remodeling as a spatial evolutionary game.” J Theor Biol 418 (April 7, 2017): 16–26. https://doi.org/10.1016/j.jtbi.2017.01.021.
       Full Text  Link to Item
    • Storey, K., M. D. Ryser, K. Leder, and J. Foo. “Spatial Measures of Genetic Heterogeneity During Carcinogenesis.” Bull Math Biol 79, no. 2 (February 2017): 237–76. https://doi.org/10.1007/s11538-016-0234-5.
       Full Text  Link to Item
    • Ryser, Marc D., Walter T. Lee, Neal E. Ready, Kevin Z. Leder, and Jasmine Foo. “Quantifying the Dynamics of Field Cancerization in Tobacco-Related Head and Neck Cancer: A Multiscale Modeling Approach.” Cancer Res 76, no. 24 (December 15, 2016): 7078–88. https://doi.org/10.1158/0008-5472.CAN-16-1054.
       Full Text  Link to Item
    • Ryser, Marc D., Mathias Worni, Elizabeth L. Turner, Jeffrey R. Marks, Rick Durrett, and E Shelley Hwang. “Outcomes of Active Surveillance for Ductal Carcinoma in Situ: A Computational Risk Analysis.” J Natl Cancer Inst 108, no. 5 (May 2016). https://doi.org/10.1093/jnci/djv372.
       Full Text  Link to Item
    • Cao, Yangxiaolu, Marc D. Ryser, Stephen Payne, Bochong Li, Christopher V. Rao, and Lingchong You. “Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria.” Cell 165, no. 3 (April 21, 2016): 620–30. https://doi.org/10.1016/j.cell.2016.03.006.
       Full Text  Link to Item
    • Worni, Mathias, Igor Akushevich, Rachel Greenup, Deba Sarma, Marc D. Ryser, Evan R. Myers, and E Shelley Hwang. “Trends in Treatment Patterns and Outcomes for Ductal Carcinoma In Situ.” J Natl Cancer Inst 107, no. 12 (December 2015): djv263. https://doi.org/10.1093/jnci/djv263.
       Full Text  Link to Item
    • Ryser, Marc D., Kevin McGoff, David P. Herzog, David J. Sivakoff, and Evan R. Myers. “Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies.” Epidemics 11 (June 2015): 32–47. https://doi.org/10.1016/j.epidem.2015.01.003.
       Full Text  Open Access Copy  Link to Item
    • Ryser, Marc D., Evan R. Myers, and Rick Durrett. “HPV clearance and the neglected role of stochasticity.” Plos Comput Biol 11, no. 3 (March 2015): e1004113. https://doi.org/10.1371/journal.pcbi.1004113.
       Full Text  Open Access Copy  Link to Item
    • Foo, Jasmine, Kevin Leder, and Marc D. Ryser. “Multifocality and recurrence risk: a quantitative model of field cancerization.” J Theor Biol 355 (August 21, 2014): 170–84. https://doi.org/10.1016/j.jtbi.2014.02.042.
       Full Text  Link to Item
    • Payne, Stephen, Bochong Li, Yangxiaolu Cao, David Schaeffer, Marc D. Ryser, and Lingchong You. “Temporal control of self-organized pattern formation without morphogen gradients in bacteria.” Mol Syst Biol 9 (October 8, 2013): 697. https://doi.org/10.1038/msb.2013.55.
       Full Text  Link to Item
    • Ryser, M. D., N. Nigam, and P. F. Tupper. “On the well-posedness of the stochastic Allen-Cahn equation in two dimensions.” Journal of Computational Physics 231, no. 6 (March 20, 2012): 2537–50. https://doi.org/10.1016/j.jcp.2011.12.002.
       Full Text
    • Hairer, Martin, Marc Ryser, and Hendrik Weber. “Triviality of the 2D stochastic Allen-Cahn equation.” Electronic Journal of Probability 17, no. none (January 1, 2012). https://doi.org/10.1214/ejp.v17-1731.
       Full Text
    • Ryser, Marc D., Yiding Qu, and Svetlana V. Komarova. “Osteoprotegerin in bone metastases: mathematical solution to the puzzle.” Plos Comput Biol 8, no. 10 (2012): e1002703. https://doi.org/10.1371/journal.pcbi.1002703.
       Full Text  Link to Item
    • Ryser, M. D., S. V. Komarova, and N. Nigam. “The cellular dynamics of bone remodeling: A mathematical model.” Siam Journal on Applied Mathematics 70, no. 6 (April 27, 2010): 1899–1921. https://doi.org/10.1137/090746094.
       Full Text
    • Ryser, Marc D., Nilima Nigam, and Svetlana V. Komarova. “Mathematical modeling of spatio-temporal dynamics of a single bone multicellular unit.” J Bone Miner Res 24, no. 5 (May 2009): 860–70. https://doi.org/10.1359/jbmr.081229.
       Full Text  Link to Item
    • Lehning, M., H. Loewe, M. D. Ryser, and N. Raderschall. “Inhomogeneous precipitation distribution and snow transport in steep terrain.” Water Resour. Res., 2008.
       Link to Item
    • Buenzli, Pascal R., Philippe A. Martin, and Marc D. Ryser. “Thermal quantum electrodynamics of nonrelativistic charged fluids.” Phys Rev E Stat Nonlin Soft Matter Phys 75, no. 4 Pt 1 (April 2007): 041125. https://doi.org/10.1103/PhysRevE.75.041125.
       Full Text  Link to Item

  • Conference Papers

    • Fridman, Ilona, Lok Chan, Jennifer Thomas, Laura J. Fish, Margaret Falkovic, Jacquelyn Brioux, Nicole Hunter, et al. “A web-based personalized decision support tool for patients diagnosed with ductal carcinoma in situ: development, content evaluation, and usability testing.” In Breast Cancer Res Treat, 192:517–27, 2022. https://doi.org/10.1007/s10549-022-06512-8.
       Full Text  Link to Item
    • Chan, Lok, Ilona Fridman, Jennifer Grant, E Shelley Hwang, Kevin Weinfurt, and Marc D. Ryser. “USING PAIRWISE SIMULATED OUTCOMES TO IMPROVE THE UNDERSTANDING OF THE STATISTICAL DIFFERENCES BETWEEN TWO RISK DISTRIBUTIONS.” In Medical Decision Making, 41:E284–86, 2021.
       Link to Item
    • Ryser, Marc D., Inmaculada C. Sorribes, Matthew Greenwald, Ethan Wu, Allison Hall, Diego Mallo, Lorraine M. King, et al. “Inferring the evolutionary dynamics of ductal carcinoma in situ through multi-regional sequencing and mathematical modeling.” In Cancer Research, Vol. 80, 2020.
       Link to Item
    • Ryser, Marc D., Laura Hendrix, Samantha M. Thomas, Thomas Lynch, Anne McCarthy, Zahed Mohammed, Amanda B. Francescatti, et al. “Ipsilateral invasive cancer risk after diagnosis with ductal carcinoma in situ (DCIS): Comparison of patients with and without index surgery.” In Journal of Clinical Oncology, Vol. 38, 2020.
       Link to Item
    • Fridman, Ilona, Vignesh Kumaresan, Prajwal Vijendra, Preethi Seshadri, Samantha Garland, Grant Kim, Angela Fagerlin, Peter A. Ubel, and Marc D. Ryser. “INFORMATION PROCESSING AND PATIENT DECISION MAKING: A BIG DATA APPROACH TO TREATMENT CHOICE IN PROSTATE CANCER PATIENTS.” In Medical Decision Making, 40:E183–84. SAGE PUBLICATIONS INC, 2020.
       Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • BIOLOGY 493: Research Independent Study 2022
  • MATH 89S: First-Year Seminar 2022
  • BIOLOGY 293: Research Independent Study 2021
  • MATH 89S: First-Year Seminar 2021
  • MATH 89S: First-Year Seminar 2020

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.