Overview
Dr. Ukraintseva studies the causes of human aging and the associated decline in whole-body resilience, with the goal of identifying genetic and other factors that drive this decline and contribute to the age-related increase in all-cause mortality risk, ultimately limiting longevity even in individuals without major diseases. She also investigates the “multi-hit” mechanism of Alzheimer’s disease and the complex, including trade‑off–like, relationships between Alzheimer’s disease and cancer. She actively explores the role of infectious diseases and compromised immunity in Alzheimer’s development, as well as the interplay between vaccines and genetic factors, to advance personalized vaccine repurposing for AD prevention. To address these questions, Dr. Ukraintseva and her team analyze large human datasets containing comprehensive information on millions of individuals. She is a PI and key investigator on several NIH-funded grants and has authored more than 150 peer‑reviewed publications, including in major journals such as JAMA, Nature group journals, Stroke, Alzheimer’s & Dementia, and others.
.Current Appointments & Affiliations
Recent Publications
Basic Science and Pathogenesis.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAPOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), with a higher effect in females than in males. Identifying factors that may reduce the detrimental impact of APOE4 on AD is an important research objecti ... Full text CiteDeveloping Topics.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAccumulating evidence points to a major role of compromised immunity in Alzheimer's Disease (AD). The MIR146a and COMT genes are both known for their involvement in immune responses, as well as in AD-related traits. COMT also regulates t ... Full text CiteDeveloping Topics.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundInfections and neuroinflammation are increasingly recognized as key contributors to the pathogenesis of Alzheimer's disease (AD). Emerging evidence suggests that the immune-regulating genes GDF15 and MIR146A are promising targets for dev ... Full text CiteRecent Grants
The Long Life Family Study
ResearchSenior Investigator · Awarded by Washington University in St. Louis · 2019 - 2030Duke/UNC ADAR Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Leveraging population-based human data to uncover mechanisms connecting Alzheimer's disease and common infections and facilitate vaccines repurposing for AD prevention
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026View All Grants