Paul Mitaari Magwene | Scholars@Duke

Paul Mitaari Magwene
Professor of Biology

Current Appointments & Affiliations

Professor of Biology, Biology, Trinity College of Arts & Sciences 2022
Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2022

Contact Information

124 Science Drive, Room 4103 Ffsc, Duke Box 90338, Durham, NC 27708
Box 90338, Durham, NC 27708
paul.magwene@duke.edu (919) 613-8159
Magwene Lab Website

Background
Education, Training, & Certifications
- Ph.D., The University of Chicago 1999
Previous Appointments & Affiliations
- Associate Professor of Biology, Biology, Trinity College of Arts & Sciences 2012 - 2022
- Associate Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2015 - 2022
- Director of the PhD Program in Computational Biology and Bioinformatics, Duke Center for Genomic and Computational Biology, Institutes and Centers 2015 - 2018
- Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2011 - 2015
- Assistant Professor of Biology, Biology, Trinity College of Arts & Sciences 2004 - 2012
- Assistant Research Professor, Biology, Trinity College of Arts & Sciences 2004
Recognition
In the News
- JAN 30, 2023 Duke Today
  
  Warmer Climate May Drive Fungi to Be More Dangerous to Our Health
Awards & Honors
- Ford Foundation Fellowships/ Dissertaton. National Academies, The. 1998
Expertise
Subject Headings
Research
Selected Grants
- The Genetic Basis of Virulence in Cryptococcus Neoformans awarded by National Institutes of Health 2017 - 2028
- Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program awarded by National Institutes of Health 2022 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Preparing Genetic Counselors for Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Nucleo-Mitochondrial quantitative traits in S. cerevisiae awarded by National Institutes of Health 2017 - 2022
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- The Genetic Architecture of Virulence in Cryptococcus Neoformans awarded by National Institutes of Health 2017
- High throughput S. cerevisiae HAM, GWA & QT/QTL architecture awarded by National Institutes of Health 2011 - 2016
- Functional Variation in a Conserved Pathway Influencing Cellular Differentiation awarded by National Institutes of Health 2014 - 2016
- Causes and Consequences of Variation in cyclic AMP - Protein Kinase A Signaling in Yeast awarded by National Science Foundation 2013 - 2016
- Collaborative Reseach: The Genomics of Adaptation in Experimental Yeast Populations During Short and Long-Term Selection on Invasive Growth awarded by National Science Foundation 2010 - 2015
- Research Initiation Grant: The Effects of Genetic Variation on Gene Networks in Yeast awarded by National Science Foundation 2006 - 2009
External Relationships
- DataHelix LLC
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gusa, Asiya, Vikas Yadav, Cullen Roth, Jonathan D. Williams, Eva Mei Shouse, Paul Magwene, Joseph Heitman, and Sue Jinks-Robertson. “Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans.” Proc Natl Acad Sci U S A 120, no. 4 (January 24, 2023): e2209831120. https://doi.org/10.1073/pnas.2209831120.
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  - Priest, Shelby J., Vikas Yadav, Cullen Roth, Tim A. Dahlmann, Ulrich Kück, Paul M. Magwene, and Joseph Heitman. “Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans.” Nat Microbiol 7, no. 8 (August 2022): 1239–51. https://doi.org/10.1038/s41564-022-01183-z.
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  - Sun, Sheng, Cullen Roth, Anna Floyd Averette, Paul M. Magwene, and Joseph Heitman. “Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.” Proc Natl Acad Sci U S A 119, no. 8 (February 22, 2022). https://doi.org/10.1073/pnas.2122293119.
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  - Montoya, Marhiah C., Paul M. Magwene, and John R. Perfect. “Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review.” J Fungi (Basel) 7, no. 4 (March 30, 2021). https://doi.org/10.3390/jof7040260.
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  - Roth, Cullen, Debra Murray, Alexandria Scott, Ci Fu, Anna F. Averette, Sheng Sun, Joseph Heitman, and Paul M. Magwene. “Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence.” Plos Genet 17, no. 1 (January 2021): e1009313. https://doi.org/10.1371/journal.pgen.1009313.
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  - Vijayraghavan, Sriram, Stanislav G. Kozmin, Pooja K. Strope, Daniel A. Skelly, Zhenguo Lin, John Kennell, Paul M. Magwene, Fred S. Dietrich, and John H. McCusker. “Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae.” Genetics 211, no. 2 (February 2019): 773–86. https://doi.org/10.1534/genetics.118.301546.
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  - Kayikci, Ömur, and Paul M. Magwene. “Divergent Roles for cAMP-PKA Signaling in the Regulation of Filamentous Growth in Saccharomyces cerevisiae and Saccharomyces bayanus.” G3 (Bethesda, Md.) 8, no. 11 (November 2018): 3529–38. https://doi.org/10.1534/g3.118.200413.
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  - Roth, Cullen, Sheng Sun, R Blake Billmyre, Joseph Heitman, and Paul M. Magwene. “A High-Resolution Map of Meiotic Recombination in Cryptococcus deneoformans Demonstrates Decreased Recombination in Unisexual Reproduction.” Genetics 209, no. 2 (June 2018): 567–78. https://doi.org/10.1534/genetics.118.300996.
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  - Ehrenreich, Ian M., and Paul M. Magwene. “Genetic Analysis of Complex Traits in Saccharomyces cerevisiae.” Cold Spring Harbor Protocols 2017, no. 6 (June 2017): pdb.top077602. https://doi.org/10.1101/pdb.top077602.
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  - Ehrenreich, Ian M., and Paul M. Magwene. “Genetic Dissection of Heritable Traits in Yeast Using Bulk Segregant Analysis.” Cold Spring Harbor Protocols 2017, no. 6 (June 2017): pdb.prot088989. https://doi.org/10.1101/pdb.prot088989.
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  - Maxwell, Colin S., and Paul M. Magwene. “When sensing is gambling: An experimental system reveals how plasticity can generate tunable bet-hedging strategies.” Evolution; International Journal of Organic Evolution 71, no. 4 (April 2017): 859–71. https://doi.org/10.1111/evo.13199.
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  - Skelly, Daniel A., Paul M. Magwene, Brianna Meeks, and Helen A. Murphy. “Known mutator alleles do not markedly increase mutation rate in clinical Saccharomyces cerevisiae strains.” Proceedings. Biological Sciences 284, no. 1852 (April 2017): 20162672. https://doi.org/10.1098/rspb.2016.2672.
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  - Maxwell, Colin S., and Paul M. Magwene. “The quick and the dead: microbial demography at the yeast thermal limit.” Molecular Ecology 26, no. 6 (March 2017): 1631–40. https://doi.org/10.1111/mec.13955.
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  - Skelly, Daniel A., and Paul M. Magwene. “Population perspectives on functional genomic variation in yeast.” Briefings in Functional Genomics 15, no. 2 (March 2016): 138–46. https://doi.org/10.1093/bfgp/elv044.
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  - Skelly, Daniel A., Paul M. Magwene, and Eric A. Stone. “Sporadic, Global Linkage Disequilibrium Between Unlinked Segregating Sites.” Genetics 202, no. 2 (February 2016): 427–37. https://doi.org/10.1534/genetics.115.177816.
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  - Strope, Pooja K., Stanislav G. Kozmin, Daniel A. Skelly, Paul M. Magwene, Fred S. Dietrich, and John H. McCusker. “2μ plasmid in Saccharomyces species and in Saccharomyces cerevisiae.” Fems Yeast Res 15, no. 8 (December 2015). https://doi.org/10.1093/femsyr/fov090.
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  - Strope, Pooja K., Daniel A. Skelly, Stanislav G. Kozmin, Gayathri Mahadevan, Eric A. Stone, Paul M. Magwene, Fred S. Dietrich, and John H. McCusker. “The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen.” Genome Res 25, no. 5 (May 2015): 762–74. https://doi.org/10.1101/gr.185538.114.
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  - Magwene, P. M. “Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast.” Advances in Experimental Medicine and Biology 781 (January 1, 2014): 37–48. https://doi.org/10.1007/978-94-7-7347-9_3.
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  - Granek, Joshua A., Debra Murray, Ömür Kayrkçi, and Paul M. Magwene. “The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.” Genetics 193, no. 2 (February 2013): 587–600. https://doi.org/10.1534/genetics.112.142067.
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  - Magwene, Paul M., and John J. Socha. “Biomechanics of turtle shells: how whole shells fail in compression.” Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology 319, no. 2 (February 2013): 86–98. https://doi.org/10.1002/jez.1773.
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  - Granek, Joshua A., Ömür Kayıkçı, and Paul M. Magwene. “Pleiotropic signaling pathways orchestrate yeast development.” Curr Opin Microbiol 14, no. 6 (December 2011): 676–81. https://doi.org/10.1016/j.mib.2011.09.004.
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  - Magwene, Paul M., John H. Willis, and John K. Kelly. “The statistics of bulk segregant analysis using next generation sequencing.” Plos Comput Biol 7, no. 11 (November 2011): e1002255. https://doi.org/10.1371/journal.pcbi.1002255.
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  - Lee, Hana N., Paul M. Magwene, and Rachel B. Brem. “Natural variation in CDC28 underlies morphological phenotypes in an environmental yeast isolate.” Genetics 188, no. 3 (July 2011): 723–30. https://doi.org/10.1534/genetics.111.128819.
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  - Magwene, Paul M., Ömür Kayıkçı, Joshua A. Granek, Jennifer M. Reininga, Zackary Scholl, and Debra Murray. “Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution in Saccharomyces cerevisiae.” Proc Natl Acad Sci U S A 108, no. 5 (February 1, 2011): 1987–92. https://doi.org/10.1073/pnas.1012544108.
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  - Gonzales, K., Omur Kayikci, D. G. Schaeffer, and P. Magwene. “Modeling mutant phenotypes and oscillatory dynamics in the \emph{Saccharomyces cerevisiae} cAMP-PKA pathway (Submitted).” Plos Computational Biology, December 2010.
  - Granek, Joshua A., and Paul M. Magwene. “Environmental and genetic determinants of colony morphology in yeast.” Plos Genet 6, no. 1 (January 22, 2010): e1000823. https://doi.org/10.1371/journal.pgen.1000823.
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  - Munger, Steven C., David L. Aylor, Haider Ali Syed, Paul M. Magwene, David W. Threadgill, and Blanche Capel. “Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.” Genes Dev 23, no. 21 (November 1, 2009): 2521–36. https://doi.org/10.1101/gad.1835809.
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  - Magwene, Paul M. “Statistical methods for studying modularity: a reply to Mitteroecker and Bookstein.” Systematic Biology 58, no. 1 (February 2009): 146–49. https://doi.org/10.1093/sysbio/syp007.
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  - Magwene, P. M. “Using correlation proximity graphs to study phenotypic integration.” Evolutionary Biology 35, no. 3 (September 1, 2008): 191–98. https://doi.org/10.1007/s11692-008-9030-y.
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  - Magwene, P. M. “Integration and modularity in biological systems: A review.” Acta Zoologica Sinica 52 (2006): 490–93.
  - Kim, J., and P. M. Magwene. “Computational challenges for integrative genomics.” Genomics and Informatics 2, no. 1 (2004): 7–18.
  - Magwene, Paul M., and Junhyong Kim. “Estimating genomic coexpression networks using first-order conditional independence.” Genome Biol 5, no. 12 (2004): R100. https://doi.org/10.1186/gb-2004-5-12-r100.
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  - Magwene, Paul M., Paul Lizardi, and Junhyong Kim. “Reconstructing the temporal ordering of biological samples using microarray data.” Bioinformatics 19, no. 7 (May 1, 2003): 842–50. https://doi.org/10.1093/bioinformatics/btg081.
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  - Stearns, Stephen C., Paul Magwene, and Paul American Society of Naturalists. “The naturalist in a world of genomics.” The American Naturalist 161, no. 2 (February 2003): 171–80. https://doi.org/10.1086/367983.
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  - Magwene, P. M. “New tools for studying integration and modularity.” Evolution 55, no. 9 (September 2001): 1734–45. https://doi.org/10.1111/j.0014-3820.2001.tb00823.x.
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  - Magwene, P. M. “Comparing ontogenetic trajectories using growth process data.” Systematic Biology 50, no. 5 (September 2001): 640–56. https://doi.org/10.1080/106351501753328785.
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  - Sereno, P. C., D. B. Dutheil, M. Iarochene, H. C. E. Larsson, G. H. Lyon, P. M. Magwene, C. A. Sidor, D. J. Varricchio, and J. A. Wilson. “Predatory Dinosaurs from the Sahara and Late Cretaceous Faunal Differentiation.” Science (New York, N.Y.) 272, no. 5264 (May 1996): 986–91. https://doi.org/10.1126/science.272.5264.986.
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  - Sereno, P. C., D. B. Dutheil, M. Iarochene, H. Larsson, G. Lyon, P. Magwene, C. Sidor, D. Varricchio, and J. Wilson. “Predatory dinosaurs from the Sahara and late Cretaceious faunal differntiation.” Science 272, no. 17 (1996): 986–91.
- Preprints
  - Priest, Shelby J., Vikas Yadav, Cullen Roth, Tim A. Dahlmann, Ulrich Kück, Paul M. Magwene, and Joseph Heitman. “Rampant transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of a human fungal pathogen,” August 11, 2021. https://doi.org/10.1101/2021.08.11.455996.
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Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
- Unknown. High School Outreach, North Carolina School for Science and Math, Systems Biology Mini-term. 2009 - 2015 2009 - 2015
- Unknown. Mathematical Biosciences Institute, Scientific Advisory Committee. 2009 - 2011 2009 - 2011
Service to the Profession
Service to Duke
- Academic Programs Committee. 2016 2016
- Chair and Member, Vice Provost for Faculty Advancement Search Committee. 2015 - 2017 2015 - 2017

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Awards & Honors

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Preprints

Recent Courses

Presentations & Appearances

Outreach & Engaged Scholarship

Service to the Profession

Service to Duke