Eric P. Spana | Scholars@Duke

Eric P. Spana
Associate Professor of the Practice of Biology

Current Appointments & Affiliations

Associate Professor of the Practice of Biology, Biology, Trinity College of Arts & Sciences 2018

Contact Information

130 Science Drive, 0050 Biological Sciences Bldg, Durham, NC 27708
Box 90338, Durham, NC 27708-1000
spana@duke.edu (919) 613-8208

Background
Education, Training, & Certifications
- Ph.D., University of Illinois, Urbana-Champaign 1995
- B.S., University of Pittsburgh 1989
Previous Appointments & Affiliations
- Assistant Professor of the Practice in the Department of Biology, Biology, Trinity College of Arts & Sciences 2011 - 2018
- Director of Undergraduate Studies of Biology, Biology, Trinity College of Arts & Sciences 2016
- Assistant Research Professor, Biology, Trinity College of Arts & Sciences 2009 - 2011
Recognition
In the News
- APR 27, 2015
  
  Trinity Honors Excellence in Teaching, Advising and Service
- JAN 21, 2015 Duke Research Blog
  
  Is the 'Wizarding Gene' Dominant or Recessive?
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- Modeling the structure & evolution of regulatory regions in eukaryotic genomes awarded by National Institutes of Health 2007 - 2013
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Spana, Eric P., Amanda B. Abrams, Katharine T. Ellis, Jason C. Klein, Brandon T. Ruderman, Alvin H. Shi, Daniel Zhu, Andrea Stewart, and Susan May. “speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene.” G3 (Bethesda) 10, no. 9 (September 2, 2020): 3387–98. https://doi.org/10.1534/g3.120.401470.
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  - Leung, Wilson, Christopher D. Shaffer, Elizabeth J. Chen, Thomas J. Quisenberry, Kevin Ko, John M. Braverman, Thomas C. Giarla, et al. “Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element.” G3 (Bethesda) 7, no. 8 (August 7, 2017): 2439–60. https://doi.org/10.1534/g3.117.040907.
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  - Seeds, Andrew M., Marco M. Tsui, Christine Sunu, Eric P. Spana, and John D. York. “Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.” Proc Natl Acad Sci U S A 112, no. 51 (December 22, 2015): 15660–65. https://doi.org/10.1073/pnas.1514684112.
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  - Leung, Wilson, Christopher D. Shaffer, Laura K. Reed, Sheryl T. Smith, William Barshop, William Dirkes, Matthew Dothager, et al. “Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.” G3 (Bethesda) 5, no. 5 (March 4, 2015): 719–40. https://doi.org/10.1534/g3.114.015966.
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  - Reitman, Zachary J., Sergey A. Sinenko, Eric P. Spana, and Hai Yan. “Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.” Blood 125, no. 2 (January 8, 2015): 336–45. https://doi.org/10.1182/blood-2014-05-577940.
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  - Lopatto, David, Charles Hauser, Christopher J. Jones, Don Paetkau, Vidya Chandrasekaran, David Dunbar, Christy MacKinnon, et al. “A central support system can facilitate implementation and sustainability of a Classroom-based Undergraduate Research Experience (CURE) in Genomics.” Cbe Life Sciences Education 13, no. 4 (January 2014): 711–23. https://doi.org/10.1187/cbe.13-10-0200.
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  - Shaffer, Christopher D., Consuelo J. Alvarez, April E. Bednarski, David Dunbar, Anya L. Goodman, Catherine Reinke, Anne G. Rosenwald, et al. “A course-based research experience: how benefits change with increased investment in instructional time.” Cbe Life Sciences Education 13, no. 1 (January 2014): 111–30. https://doi.org/10.1187/cbe-13-08-0152.
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  - Cook, R. K., M. E. Deal, J. A. Deal, R. D. Garton, C. A. Brown, M. E. Ward, R. S. Andrade, E. P. Spana, T. C. Kaufman, and K. R. Cook. “A New Resource for Characterizing X-linked Genes in Drosophila melanogaster: Systematic Coverage and Subdivision of the X Chromosome with Nested, Y-linked Duplications.” Genetics, September 2010. https://doi.org/10.1534/genetics.110.123265.
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  - Ni, Ting, David L. Corcoran, Elizabeth A. Rach, Shen Song, Eric P. Spana, Yuan Gao, Uwe Ohler, and Jun Zhu. “A paired-end sequencing strategy to map the complex landscape of transcription initiation.” Nat Methods 7, no. 7 (July 2010): 521–27. https://doi.org/10.1038/nmeth.1464.
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  - Maynard, Jason C., Trang Pham, Tianli Zheng, Angela Jockheck-Clark, Helen B. Rankin, Christopher B. Newgard, Eric P. Spana, and Christopher V. Nicchitta. “Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control.” Dev Biol 339, no. 2 (March 15, 2010): 295–306. https://doi.org/10.1016/j.ydbio.2009.12.023.
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  - Zhang, Yu, John H. Malone, Sara K. Powell, Vipul Periwal, Eric Spana, David M. Macalpine, and Brian Oliver. “Expression in aneuploid Drosophila S2 cells.” Plos Biol 8, no. 2 (February 23, 2010): e1000320. https://doi.org/10.1371/journal.pbio.1000320.
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  - Shaffer, C. D., C. Alvarez, C. Bailey, D. Barnard, S. Bhalla, C. Chandrasekaran, V. Chandrasekaran, et al. “The genomics education partnership: successful integration of research into laboratory classes at a diverse group of undergraduate institutions.” Cbe Life Sciences Education 9, no. 1 (2010): 55–69. https://doi.org/10.1187/09-11-0087.
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  - Goodman, Robyn M., Shreya Thombre, Zeynep Firtina, Dione Gray, Daniella Betts, Jamie Roebuck, Eric P. Spana, and Erica M. Selva. “Sprinter: a novel transmembrane protein required for Wg secretion and signaling.” Development (Cambridge, England) 133, no. 24 (December 2006): 4901–11. https://doi.org/10.1242/dev.02674.
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  - Erickson, Jeremy N., and Eric P. Spana. “Mapping Drosophila genomic aberration breakpoints with comparative genome hybridization on microarrays.” Methods in Enzymology 410 (January 2006): 377–86. https://doi.org/10.1016/s0076-6879(06)10018-x.
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  - Kirilly, Daniel, Eric P. Spana, Norbert Perrimon, Richard W. Padgett, and Ting Xie. “BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.” Developmental Cell 9, no. 5 (November 2005): 651–62. https://doi.org/10.1016/j.devcel.2005.09.013.
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  - Seeds, Andrew M., Joshua C. Sandquist, Eric P. Spana, and John D. York. “A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster.” J Biol Chem 279, no. 45 (November 5, 2004): 47222–32. https://doi.org/10.1074/jbc.M408295200.
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  - Sasamura, Takeshi, Nobuo Sasaki, Fumiyasu Miyashita, Shiho Nakao, Hiroyuki O. Ishikawa, Mikiko Ito, Motoo Kitagawa, et al. “neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions.” Development (Cambridge, England) 130, no. 20 (October 2003): 4785–95. https://doi.org/10.1242/dev.00679.
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  - Cabrero, Pablo, Jonathan C. Radford, Kate E. Broderick, Laurence Costes, Jan A. Veenstra, Eric P. Spana, Shireen A. Davies, and Julian A. T. Dow. “The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP.” The Journal of Experimental Biology 205, no. Pt 24 (December 2002): 3799–3807. https://doi.org/10.1242/jeb.205.24.3799.
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  - Song, Ho-Juhn, Jean-Christophe Billeter, Enrique Reynaud, Troy Carlo, Eric P. Spana, Norbert Perrimon, Stephen F. Goodwin, Bruce S. Baker, and Barbara J. Taylor. “The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila.” Genetics 162, no. 4 (December 2002): 1703–24. https://doi.org/10.1093/genetics/162.4.1703.
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  - Spana, E., and N. Perrimon. “The latest in signal transduction, 1999. Specificity in Signal Transduction, Keystone, Colorado, USA, 9-14 April 1999.” Trends in Genetics : Tig 15, no. 8 (August 1999): 301–2. https://doi.org/10.1016/s0168-9525(99)01791-6.
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  - Srinivasan, S., C. Y. Peng, S. Nair, J. B. Skeath, E. P. Spana, and C. Q. Doe. “Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero.” Developmental Biology 204, no. 2 (December 1998): 478–87. https://doi.org/10.1006/dbio.1998.9079.
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  - Spana, E. P., and C. Q. Doe. “Numb antagonizes Notch signaling to specify sibling neuron cell fates.” Neuron 17, no. 1 (July 1996): 21–26. https://doi.org/10.1016/s0896-6273(00)80277-9.
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  - Broadus, J., J. B. Skeath, E. P. Spana, T. Bossing, G. Technau, and C. Q. Doe. “New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system.” Mechanisms of Development 53, no. 3 (November 1995): 393–402. https://doi.org/10.1016/0925-4773(95)00454-8.
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  - Doe, C. Q., and E. P. Spana. “A collection of cortical crescents: asymmetric protein localization in CNS precursor cells.” Neuron 15, no. 5 (November 1995): 991–95. https://doi.org/10.1016/0896-6273(95)90088-8.
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  - SPANA, E. P., and C. Q. DOE. “ASYMMETRIC LOCALIZATION OF PROSPERO AND NUMB SPECIFIES CELL FATES IN THE DROSOPHILA CNS.” Molecular Biology of the Cell 6 (November 1, 1995): 1358–1358.
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  - Spana, E. P., C. Kopczynski, C. S. Goodman, and C. Q. Doe. “Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS.” Development (Cambridge, England) 121, no. 11 (November 1995): 3489–94. https://doi.org/10.1242/dev.121.11.3489.
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  - Spana, E. P., and C. Q. Doe. “The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila.” Development (Cambridge, England) 121, no. 10 (October 1995): 3187–95. https://doi.org/10.1242/dev.121.10.3187.
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  - Campbell, G., H. Göring, T. Lin, E. Spana, S. Andersson, C. Q. Doe, and A. Tomlinson. “RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila.” Development (Cambridge, England) 120, no. 10 (October 1994): 2957–66. https://doi.org/10.1242/dev.120.10.2957.
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  - Oliver, G., B. Sosa-Pineda, S. Geisendorf, E. P. Spana, C. Q. Doe, and P. Gruss. “Prox 1, a prospero-related homeobox gene expressed during mouse development.” Mechanisms of Development 44, no. 1 (November 1993): 3–16. https://doi.org/10.1016/0925-4773(93)90012-m.
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Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Presentations & Appearances
- Mapping and Cloning Adult Visible Wing Mutations in an Undergraduate Laboratory Course in Genetics and Developmental Biology. December 10, 2013 2013
- Mapping and Cloning Adult Visible Wing Mutations in an Undergraduate Laboratory Course in Genetics and Developmental Biology. December 6, 2013 2013

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Recent Courses

Presentations & Appearances